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  • Advancing Nanotechnology for Photoacoustic Imaging

    Creator:
    St Lorenz, Anna
    Abstract:
    Curbing overall disease burden with faster intervention requires early stage and accurate diagnostics. Ultrasound (US) provides a safe, nonionizing, inexpensive, and noninvasive imaging modality that has become commonplace in diagnostics. Paired with the relatively new technology of photoacoustic imaging (PAI), optical level resolution becomes feasible with the deeper signal penetration...
    Resource Type:
    Dissertation
    Full Text:
    Taratula, Dr. Theresa Filtz, Dr. Adam Alani, Dr. Claudia Hase. Chapter 1 This chapter was written by

  • Development of Novel Therapeutic Approach for Ewing’s Sarcoma Treatment

    Creator:
    Sabei, Fahad Yahya
    Abstract:
    Ewing sarcoma (EwS) is the second most highly malignant tumor that arises mainly from bone and surrounding soft tissue of adolescent and young adult patients. Despite the advances in Ewing sarcoma treatment that today include a combination of five chemotherapeutic agents, surgery, and/or radiotherapy, these therapies have demonstrated limited improvement...
    Resource Type:
    Dissertation
    Full Text:
    would like to thank all of my committee members, Drs. Adam Alani, Gaurav Sahay, Jung Kwon for their

  • In Vitro Evaluation of Therapeutic Laser Treatment on Equine Tendon Fibroblasts

    Creator:
    Husby, Kirsty A.
    Abstract:
    Previous investigations have failed to show benefits of low level laser therapy (LLLT) for tendon healing in horses, contrary to reports in other species. We hypothesized that delivery of LLLT at manufacturer-recommended energy fluence through equine cadaver skin to equine tendon-derived fibroblasts in vitro would increase cell proliferation, metabolic activity...
    Resource Type:
    Masters Thesis
    Full Text:
    , and Dr. Adam Alani for their time and help during my Master’s program. I would also like to

  • Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

    Creator:
    Kim, Jeonghwan
    Abstract:
    Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
    Resource Type:
    Dissertation
    Full Text:
    like to thank my thesis committee, Prof. Adam Alani, Prof. Conroy Sun, Prof. Arup Indra, and Prof

  • Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

    Creator:
    DuRoss, Allison N.
    Abstract:
    The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
    Resource Type:
    Dissertation
    Full Text:
    person and scientist that exists today. To my committee members, Dr. Adam Alani, Dr. Cecily Bishop

  • Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

    Creator:
    Albarqi, Hassan Ahmad M.
    Abstract:
    Despite advances in treatment, cancer remains among the leading causes of death in the world. Progress in the treatment of metastatic cancers was seen with chemotherapy and radiotherapy, however, the major drawbacks of conventional cancer therapies are limited efficacy and severe side effects. Magnetic fluid hyperthermia (MFH) is a new...
    Resource Type:
    Dissertation
    Full Text:
    I hope the project goes from strength to strength. Many thanks to Drs. John Christensen, Adam

  • Bcl11b is at the Nexus of Wnt and MAP Kinase Signaling Pathways in Two Stages of Thymocyte Development

    Creator:
    Selman, Wisam H.
    Abstract:
    Leukemogenesis, uncontrolled proliferation of dysfunctional, transformed immature lymphocytes, appears, especially in children, to be associated with abrogation of normal lymphopoiesis, and thymopoiesis in the case of T cell leukemias. Sequence specific transcription factors (SSTFs) are nuclear control switches that respond to cellular signals to alter cell state and cell fate...
    Resource Type:
    Dissertation
    Full Text:
    experiments. Special thanks to Dr. Adam Alani for both his genial demeanor and for his extraordinary support

  • Application of Bootstrap Methods in Bioequivalence Studies for Oral Generic Prodrug Products

    Creator:
    Li, Wenjing
    Abstract:
    The methodology to perform bioequivalence studies for prodrug products has not been finalized by FDA leaving the investigators to speculate over the proper approach. This study innovatively utilized the bootstrap methods for testing in vivo bioequivalence on both parent drug and metabolite of four prodrug products: Clopidogrel, Prednisone, Allopurinol, and...
    Resource Type:
    Dissertation
    Full Text:
    . committee: Adam Alani, Ph.D.; Harold Bae, Ph.D.; Oleh Taratula, Ph.D.; and Lan Xue, Ph.D.. Without their

  • A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

    Creator:
    Schumann, Canan B.
    Abstract:
    Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic...
    Resource Type:
    Dissertation
    Full Text:
    immensely; Dr. Arup Indra, Dr. Adam Alani, Dr. Theresa Filtz (her academic guidance was absolutely amazing

  • Pharmacokinetics of Flunixin in Elephants, Cefovecin in African Lions, and Gamithromycin in Alpacas

    Creator:
    Alshahrani, Sultan M.
    Abstract:
    Foot pathology is a real problem in captive elephants. Osteoarthritis is the major concern among musculoskeletal disorders and foot health problems for elephants in North America zoos with one-­‐half of Elephants in captivity showing foot health care problems in zoos. A higher ratio of captive Asian elephants (Elephas maximus) is...
    Resource Type:
    Dissertation
    Full Text:
      committee  members   Dr.   Adam  Alani,   Dr.   Oleh   Taratula,   and   Dr.   Conroy