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Filtering by: Creator Taratula, Olena Remove constraint Creator: Taratula, Olena Peer Reviewed No Remove constraint Peer Reviewed: No

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  • Advancing Nanotechnology for Photoacoustic Imaging

    Creator:
    St Lorenz, Anna
    Abstract:
    Curbing overall disease burden with faster intervention requires early stage and accurate diagnostics. Ultrasound (US) provides a safe, nonionizing, inexpensive, and noninvasive imaging modality that has become commonplace in diagnostics. Paired with the relatively new technology of photoacoustic imaging (PAI), optical level resolution becomes feasible with the deeper signal penetration...
    Resource Type:
    Dissertation
    Full Text:
    Pharmacy, The Department of Pharmaceutical Sciences and my thesis committee: Dr. Oleh Taratula, Dr. Olena

  • Non-viral Vectors for Ocular Gene Delivery

    Creator:
    Herrera-Barerra, Marco, F.
    Abstract:
    Nucleic acid therapeutics has cemented itself as one of the most efficacious and robust avenues for treatment of a wide range of diseases from vaccine development to treatment of liver, retina, cancer applications. Non-viral mediated gene delivery using lipid-based nanoparticle (LNP) carriers has proven its compatibility with addressing unexpected, fast...
    Resource Type:
    Dissertation
    Full Text:
    . Oleh Taratula and Dr. Conroy Sun provided input during for manuscript finalization. Dr. Gaurav

  • A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

    Creator:
    Schumann, Canan B.
    Abstract:
    Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic...
    Resource Type:
    Dissertation
    Full Text:
    his amazing wife Dr. Olena Taratula. Thank you for being there for me and letting me bounce ideas

  • Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

    Creator:
    Albarqi, Hassan Ahmad M.
    Abstract:
    Despite advances in treatment, cancer remains among the leading causes of death in the world. Progress in the treatment of metastatic cancers was seen with chemotherapy and radiotherapy, however, the major drawbacks of conventional cancer therapies are limited efficacy and severe side effects. Magnetic fluid hyperthermia (MFH) is a new...
    Resource Type:
    Dissertation
    Full Text:
    like to thank Dr. Oleh Taratula and his amazing wife Dr. Olena Taratula for their advice, guidance

  • Development of Novel Therapeutic Approach for Ewing’s Sarcoma Treatment

    Creator:
    Sabei, Fahad Yahya
    Abstract:
    Ewing sarcoma (EwS) is the second most highly malignant tumor that arises mainly from bone and surrounding soft tissue of adolescent and young adult patients. Despite the advances in Ewing sarcoma treatment that today include a combination of five chemotherapeutic agents, surgery, and/or radiotherapy, these therapies have demonstrated limited improvement...
    Resource Type:
    Dissertation
    Full Text:
    Writing by Fahad Yahya I. Sabei, with editing and revision by Dr. Oleh Taratula and Olena Taratula

  • Development of thermosensitive injectable hydrogel and transdermal controlled release formulations for Tacrolimus

    Creator:
    Nguyen, Duc X.
    Abstract:
    TAC is the most commonly used medication in post transplantation maintenance immunosuppression therapy. TAC lipophilicity and its erratic oral absorption especially in the presence of food intake result in great intra- and interpatient pharmacokinetic variations. Complicated dosing and frequent required therapeutic monitoring is thought to be the main cause of...
    Resource Type:
    Dissertation
    Full Text:
    many other works. I would like to thank my committee members Dr. Mark Christensen, Dr. Oleh Taratula

  • Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

    Creator:
    Doddapaneni, Bhuvana S.
    Abstract:
    Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
    Resource Type:
    Dissertation
    Full Text:
    my committee members Dr Oleh Taratula, Dr Mark Christensen, Dr Arup Indra and Dr Julie Greenwood

  • Nanotheraputic Platforms to address Chemotherapeutic Challenges in Breast and Ovarian Cancer Treatment

    Creator:
    Al Fatease, Adel
    Abstract:
    Utilizing nanocarrier based drug delivery for improving the magnitude of efficacy of chemotherapeutic agents in many diseases has acquired more attention in research applications. It has shown promising results in both preclinical and clinical trials. The Food and Drug Administration (FDA) has approved many of these polymeric carriers, and tens...
    Resource Type:
    Dissertation
    Full Text:
    my graduate committee members, Dr. John Mark Christensen, Dr. Oleh Taratula, Dr. Olena Taratula

  • The role of the transcriptional regulatory protein BCL11B in dental and craniofacial development

    Creator:
    Kyrylkova, Kateryna
    Abstract:
    BCL11B is a transcriptional regulatory protein that plays essential roles during mouse embryonic development. BCL11B is expressed and functions in the immune and nervous systems as well as within ectodermal organs. Multiple studies have characterized the roles of BCL11B in T cells, brain, and skin. However, very little is known...
    Resource Type:
    Dissertation
    Full Text:
    Dr. Jane Ishmael, Dr. Theresa Filtz, Dr. Olena Taratula, Dr. Natalia Shulzhenko, Drs. Gitali and

  • The Role of Materials Chemistry in Designing Advanced Color Inorganic Pigments

    Creator:
    Medina, Elena A.
    Abstract:
    The results of the research presented in this work are related to synthesis and investigations of novel color inorganic pigments having various structures and shades. Inorganic pigments play a major role in contemporary life. They are used in paints, rubber, plastic, cosmetics etc. Searching for new, stable, environmentally benign and...
    Resource Type:
    Dissertation
    Full Text:
    Russia: Bаня Марченко and Вероника Vasylkivska, Oleh and Olena Taratula, Нана and Миша Яцкины, Валера