The synthesis of isoindazoles bearing α-ketoester and α-hydroxyester groups via the coarctate cyclization of ester terminated azo-ene-yne precursors is described. Whereas previous studies on isoindazole formation have shown the reaction to proceed through a kinetic coarctate pathway, functionalization of the terminal acetylene with a methyl ester sufficiently stabilizes the carbene...
Sustaining forest resources requires a better understanding of forest ecosystem processes, and how management decisions and climate change may affect these processes in the future. While plot and inventory data provide our most detailed information on forest carbon, energy, and water cycling, applying this understanding to broader spatial and temporal...
Chordomas are uncommon neoplasms arising from notochord remnants, most commonly
occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and
primary intestinal chordomas have not been reported. Herein we report 24 cases of spontaneous
primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas....
Reproductive and endocrine disruption is commonly reported in aquatic species exposed to complex contaminant mixtures. We previously reported that Atlantic killifish (Fundulus heteroclitus) from the chronically contaminated Newark Bay, NJ, exhibit multiple endocrine disrupting effects, including inhibition of vitellogenesis (yolk protein synthesis) in females and false negative vitellogenin biomarker responses...
Given image data of a fluid flow, the flow field, < u, v >, governing the evolution of the system can be estimated using a variational approach to optical flow. Assuming that the flow field governing the advection is the symplectic gradient of a stream function or the gradient of...
The solid solutions of InGa₁₋ₓFeₓCuO₄, InFeCu₁₋ₓMgₓO₄, and InGa₁₋ₓFeₓCu₁₋ₓMgₓO₄ were
synthesized and characterized through the use of X – ray and neutron diffraction, and DC –
magnetism measurements. All compositions of InGa₁₋ₓFeₓCuO₄ are single phase and crystallize
in the R3m space group, but a transformation to the spinel InFeMgO₄ structure was...
The design of a projectile delivery system often plays a critical role in the durability and breakage patterns associated with spent projectile points. This paper presents the results of an experimental project designed to examine projectile point durability and breakage patterns between three different hafting methods. Specifically, we compare two...
The Queen Charlotte fault (QCF) is a dextral transform system located offshore of southeastern Alaska and western Canada, accommodating ∼4.4 cm/yr of relative motion between the Pacific and North American plates. Oblique convergence along the fault increases southward, and how this convergence is accommodated is still debated. Using seismic reflection...
Where a legacy of aggressive wildland fire suppression has left forests in need of fuel reduction, allowing wildland fire to burn may provide fuel treatment benefits, thereby reducing suppression costs from subsequent fires. The least-cost-plus-net-value-change model of wildland fire economics includes benefits of wildfire in a framework for evaluating suppression...
The Queen Charlotte Fault (QCF) is a major strike-slip fault that forms the boundary between the Pacific and North American plates from 51° to 58° N. Near 53.2° N, the angle of oblique convergence predicted by the Mid-Ocean Ridge VELocity (MORVEL) interplate pole of rotation decreases from >15° in the...