The aspidosperma alkaloid goniomitine was synthesized in six steps from 2-ethyl-δ-valerolactam. The convergent strategy features an Ullman coupling to assemble the required carbon atoms. A complexity-generating radical translocation reaction was used to build the indole architecture.
A pyrone Diels–Alder strategy was developed for the synthesis of the cyclophane natural product, cavicularin. The strategy uses a vinyl sulfone as an alkyne equivalent dienophile. An enantioselective variant delivered (+)-cavicularin.
Restricted rotations of chemical bonds can lead to the presence of persistent conformational chirality in molecules 10 lacking stereocenters. We report the development of first-ofa- kind predictive rules that enable identification of conformational chirality and prediction of racemization barriers in the diarylether heptanoid (DAEH) natural products that do not possess...
Stream temperatures were monitored on seven low-elevation western Oregon streams immediately after clearcut harvesting and 14-17 years later in two studies that examined buffer designs. One study on four streams used no-tree buffers with all trees next to the stream harvested within the clearcut units. The second study on three...
Most sweet cherries produced in the US Pacific Northwest and shipped to distant markets are often in storage and transit for over 3 weeks. The objectives of this research were to study the effects of sweet cherry storage O2 and CO2 concentrations on the respiratory physiology and the efficacy of...
The production and export of late season sweet cherry cultivars continues to increase in the US Pacific Northwest (PNW). Major postharvest quality deterioration during long distance ocean shipping include flavor loss, off-flavor development, skin darkening, pedicel browning, pitting, and decay. In this research, three modified atmosphere packaging (MAP) liners with...
We estimate the impact of strict and multiple use protected areas on forest disturbance in European Russia between 1985 and 2010. We construct a spatial panel dataset that includes five periods of change. We match protected areas to control observations and compare coefficients from fixed versus random effects models. We...
Respondent-driven sampling (RDS) is used throughout the world to estimate prevalence and population size for hidden populations. Although RDS is an effective method for enrolling people from key populations in studies, it relies on a partially unknown sampling mechanism, and thus each individual’s inclusion probability is unknown. Current estimators for...
Contextualization is a curricular approach and a learning process in which science content knowledge is intentionally situated within a context where that knowledge can be authentically applied or observed. Many recent science education reforms include contextualization as a central tenet. Our goal in this review was to examine commonalities across...
Internal browning (IB) can be a serious problem with the use of modified atmosphere packaging
(MAP) for 'Bartlett' pears (Pyrus communis L.) grown in the Pacific Northwest during storage
and transit to distant markets. To investigate this disorder, 'Bartlett' pears harvested at
commercial maturity were packed in a commercial MAP...