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Total Synthesis of (±)-Goniomitine via Radical Translocation

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https://ir.library.oregonstate.edu/concern/articles/h415pg16t

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Abstract
  • The aspidosperma alkaloid goniomitine was synthesized in six steps from 2-ethyl-δ-valerolactam. The convergent strategy features an Ullman coupling to assemble the required carbon atoms. A complexity-generating radical translocation reaction was used to build the indole architecture.
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  • Vellucci, J. K., & Beaudry, C. M. (2015). Total Synthesis of (±)-Goniomitine via Radical Translocation. Organic Letters, 17(18), 4558-4560. doi:10.1021/acs.orglett.5b02277
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  • 17
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  • 18
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  • This work was supported by the National Science Foundation under Grant Number 1465287.
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