Endoxifen has recently been identified as the predominant active metabolite of tamoxifen and is currently being developed as a novel hormonal therapy for the treatment of endocrine sensitive breast cancer. Based on past studies in breast cancer cells and model systems, endoxifen classically functions as an anti-estrogenic compound. Since estrogen...
In western conifer-dominated forests where the abundance of old-growth stands is decreasing, species
such as the Brown Creeper (Certhia americana) may be useful as indicator species for monitoring the health
of old-growth systems because they are strongly associated with habitat characteristics associated with old growth
and are especially sensitive to...
Una de las herramientas más eficaces utilizadas por el Malheur Experiment Station durante las últimas dos décadas es el sensor matricial granular (o GMS por sus siglas en inglés), el cual mide la humedad del suelo. El sensor tiene sólo 7,5 cm de largo, y normalmente se entierra verticalmente en...
As computational power increases, so does the desire to use computational simulations while designing fuel plates. The downside is multi-physics simulations – or more specifically, fluid–structure interactions (FSI) as addressed herein – require a larger amount of computational resources. Current simulations of a single plate can take weeks on a...
Ocean island basalts (OIB) with extremely radiogenic Pb-isotopic signatures are melts of a mantle component called HIMU (high µ, high ²³⁸U/²⁰⁴Pb). Until now, deeply dredged submarine HIMU glasses have not been available, which has inhibited complete geochemical (in particular, volatile element) characterization of the HIMU mantle. We report major, trace...
We investigate a method for numerically generating discrete scattering cross sections for use in charged particle transport simulations. We describe the cross section generation procedure and compare it to existing methods used to obtain discrete cross sections. The numerical approach presented here is generalized to allow greater flexibility in choosing...
Koi herpesvirus (KHV) infection is associated with high mortalities in both common carp (Cyprinus carpio carpio) and koi carp (Cyprinus carpio koi) worldwide. Although acute infection has been reported in both domestic and wild common carp, the status of KHV latent infection is largely unknown in wild common carp. To...
Diatom remains indicate the oceanic Ge/Si ratio (μmol/mol) has varied temporally, ranging from Miocene values of 0.9 to Last Glacial Maximum (LGM) values of 0.55, with the present value of 0.69. These ratios lie between those for the primary sources for these elements: continental weathering (Ge/Si = 0.5) and hydrothermal...
Bisphenol A (BPA), a high-volume chemical used to make polycarbonate plastic and epoxy resins, is a ubiquitous contaminant in environment and human body. To investigate the reproductive effects of long-term exposure to low concentrations of BPA, a two-generation study was conducted using the aquatic model species of zebrafish. Our findings...
A new in situ fluorometer for the detection of oceanic photosynthetic pigment fluorescence is described.
Emission spectra from 546 to 733 nm are recorded for each of three different visible excitation bands ten
times a second. A Spectralon cell is used to improve the excitation coupling to and the collection...