An experimentally based, quantitative understanding of the entrapment and function of small peptides within PEO brush layers does not currently exist. Earlier work provided a rationale for expecting that an ordered, compact peptide will enter the PEO phase more readily than a peptide of similar size that adopts a less...
In earlier work, we have provided direction for development of responsive drug delivery systems based on modulation of structure and amphiphilicity of bioactive peptides entrapped within pendant polyethylene oxide (PEO) brush layers. Amphiphilicity promotes retention of the peptides within the hydrophobic inner region of the PEO brush layer. In this...
Desferrioxamine B (DFOB) was reversibly and covalently conjugated to polystyrene microspheres via N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP) crosslinker. DFOB retained post-immobilization activity with at least 89% able to bind Fe(III)-citrate under pH 7.4 and a citrate:iron molar ratio = 100:1. Comparing iron capture by DFOB-activated beads and sulfhydryl (−SH) control beads demonstrated...
Purpose: To determine if the associations among established risk factors and reduced kidney function vary by age.
Methods: We pooled cross-sectional data from 14,788 nondiabetics aged 40 to 100 years in 4 studies: Cardiovascular Health Study, Health, Aging, and Body Composition Study, Multi-Ethnic Study of Atherosclerosis, and Prevention of Renal...
BACKGROUND: Chronic exposure to arsenic is associated with skin lesions. However, it is not known whether reducing arsenic exposure will improve skin lesions.
OBJECTIVE: We evaluated the association between reduced arsenic exposures and skin lesion recovery over time.
METHODS: A follow-up study of 550 individuals was conducted in 2009-2011 on...
This study examined the perceptions of team members of a sister library initiative between Nimbe Adedipe Library, Federal University of Agriculture, Abeokuta, Nigeria and the Valley Library, Oregon State University, Corvallis, USA. An online survey and focus group discussion were used as data collecting instruments. All of the 26 members...
Nech Sar National Park (NSNP) is one of the most important biodiversity centers in Ethiopia. In recent years, a widespread decline of the terrestrial ecosystems has been reported, yet to date there is no comprehensive assessment on degradation across the park. In this study, changes in landcover were analyzed using...
Dendrimers are well-defined, polymeric nanomaterials currently being investigated for biomedical applications such as medical imaging, gene therapy, and tissue targeted therapy. Initially, higher generation (size) dendrimers were of interest because of their drug carrying capacity. However, increased generation was associated with increased toxicity. The majority of studies exploring dendrimer toxicity...
Arsenic contamination is a serious problem in rice cultivated soils of many developing countries. Hence, it is critical to monitor and control arsenic uptake in rice plants to avoid adverse effects on human health. This study evaluated the feasibility of using reflectance spectroscopy to monitor arsenic in rice plants. Four...