The isothiocyanate sulforaphane is a promising molecule for development as a therapeutic agent for patients with metastatic
prostate cancer. Sulforaphane induces apoptosis in advanced prostate cancer cells, slows disease progression in vivo and is well
tolerated at pharmacological doses. However, the underlying mechanism(s) responsible for cancer suppression remain to be...
Shear wave velocity is a fundamental property of a granular assembly. It is a measure of the true elastic stiffness of a bulk specimen of discrete grains. Shear wave velocity is typically measured in the laboratory (e.g., using bender elements) or in-situ (e.g., using a seismic cone penetrometer, sCPT). In...
Many protected areas or parks in developing countries have buffer zones at their
boundaries to achieve the dual goals of protecting park resources and providing
resource benefits to neighbouring people. Despite the prevalence of these zoning
policies, few behavioural models of people’s buffer zone use inform the sizing and
management...
OBJECTIVE: Pharmacokinetic interactions exist between combined
oral contraceptives and protease inhibitors (PI). However, such
information is lacking for progestin-only oral contraception. We
sought to define the steady-state pharmacokinetic interaction between
norethindrone (NET) and PI in HIV-infected women.
METHODS AND DESIGN: We conducted an open-label, prospective,
nonrandomized trial to characterize the...
The slow β relaxation is understood to be a universal feature of glassy dynamics. Its presence in bulk metallic
glasses (BMGs) is evidence of a broad relaxation time spectrum that extends to deep within the glassy state.
Despite the breadth of research devoted to this phenomenon, its microscopic origin is...
Dual-axis accelerometer global positioning system collars can be used to remotely record the activity level and behavior of free-ranging animals, but inter- and intraspecific variations in motion among behaviors necessitate calibration for each species of interest. To date, little work has been done to determine the best duration for sampling...
Identifying coherent sub-graphs in networks is important
in many applications. In power systems, large systems
are divided into areas and zones to aid in planning and control
applications. But not every partitioning is equally good for
all applications; different applications have different goals, or
attributes, against which solutions should be...
The heat pulse probe method can be implemented with actively heated fiber optics (AHFO) to obtain distributed measurements of soil water content (θ) by using reported soil thermal responses measured by Distributed Temperature Sensing (DTS) and with a soil-specific calibration relationship. However, most reported applications have been calibrated to homogeneous...
Production of Kþ mesons in charged-current νμ interactions on plastic scintillator (CH) is measured using MINERvA exposed to the low-energy NuMI beam at Fermilab. Timing information is used to isolate a sample of 885 charged-current events containing a stopping Kþ which decays at rest. The differential cross section in Kþ...
Developmental changes in the carotenoids and volatile compounds of Pinot noir grape berries were investigated in this study from pea size to harvest during 2012. HPLC analysis showed continued decrease of lutein, β-carotene, neochrome a and neoxanthin continued to decrease during berry development, with rapid decrease of lutein and (9′z)-neoxanthin...