The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is an important regulator of immune responses in various disease models. In the non-obese diabetic (NOD) mouse model of type 1 diabetes, activation of this receptor leads to suppression of the autoimmune response and limits immune cell infiltration of...
Wildfires are increasing in frequency. One area of research interest centers on the pollutants within wildfire smoke, including but not limited to particulate matter and polycyclic aromatic hydrocarbons. These chemicals are associated with exacerbation of respiratory, cardiovascular, dermatological, reproductive, oncological, gastrointestinal, and infectious conditions. As wildfires becoming increasingly prevalent, it...
The last two years of the Covid-19 pandemic have brought significant changes to global and American societies, as well as to our healthcare system. Millions of Americans were laid off and left without insurance, some areas of medicine suffered financial catastrophe with a fall in patient volumes, others were victims...
Polycyclic Aromatic Hydrocarbons (PAHs) have been studied for their carcinogenic toxicity. PAHs are formed by incomplete carbon combustion. Benzo[a]pyrene (BaP) is an IARC classified Class 1 Human carcinogenic PAH. New studies are conducted to gain a better understanding of PAHs and how to reduce exposure. Glutathione S-transferase M 1 (GSTM1...
The increased severity of unseasonal drought conditions in the American Southwest have resulted in herbivorous species, like the desert bighorn sheep (Ovis canadensis nelsoni), receiving lower quality forage in their diet at less reliable frequency. The Mojave Desert and the Peninsular Mountain ranges also contain large variations in elevation, which...
Accurate estimation of the amount of water used by trees is important for a variety of agricultural applications. There are several current methodologies for measuring sap flow and water use in trees, however the heat ratio method has been identified as the ideal due to its ability to measure low...
Pseudocapillaria tomentosa is a nematode that parasitizes Danio rerio, causing major disease that affects the economic commodities of fish industries and destroys experimental results at research facilities. There is a critical need for a rapid and sensitive diagnostic assay to test for P. tomentosa in D. rerio populations. PCR primers...
Profile Hidden Markov Models utilize the information stored in a multiple sequence alignment such as its residues and conserved regions to assign probabilities at each column. This indicates areas in the sequences where similar functionality is observed. These probability weights are then combined to assign a sequence score, which is...
The Polycomb Repressive Complex 2 (PRC2) catalyzes genome transcription repression through the methylation of lysine residue 27 in the amino terminal region of histone 3 (H3K27me1/2/3) [2], [7]. PRC2 is made up of three highly conserved core subunits: Kmt6, Eed, and Suz12. Accurate distribution of PRC2 is essential for proper...
From my personal experiences, I’ve noticed that Latinx students and families are most receptive to college-related information communicated as anecdotes. Latinx students are among the most poorly represented demographic at universities nationwide, which I believe can be mitigated through calculated efforts to increase collegiate literacy and understanding. This project is...