Index Catalog // ScholarsArchive@OSU

State-of-the-Art Combination Therapies and Nanomedicines for Triple Negative Breast Cancer

Creator:: Fabbi, Meagan C.
Abstract:: Triple-negative breast cancer (TNBC) is a particularly aggressive molecular subtype of malignant cells that tends to proliferate quickly and is commonly resistant to traditional chemotherapy leading to relapses in prognosis more frequently than other forms of breast cancer (BCa) [1][2][3]. Current treatment options include surgical resection of cancerous tissue and...
Resource Type:: Honors College Thesis
Full Text:: Cancer Abstract approved: _______________________________________________________ Conroy Sun

Transcription Factors Associated with Tomato Seed Germination

Creator:: Sun, Jing
Abstract:: Seed germination is strictly defined as the physiological events before radicle protrusion through the endosperm cap, the endosperm region adjacent to the radicle tip. There are two opposing forces governing seed germination: the growth potential of the embryo and the mechanical resistance of the endosperm cap. The endosperm cap cell...
Resource Type:: Honors College Thesis
Full Text:: THE THESIS OF Jing Sun for the degree of Honors Baccalaureate of Science in Microbiology presented

Optimization of NH2-MIL-88B (Fe) for reactive oxygen species generation

Creator:: Shotton, Lewis
Abstract:: Metal-organic frameworks (MOFs) have emerged as promising candidates in novel cancer therapies due to their unique properties, including high surface area, tunable crystal size, and exposed metal ion active sites for catalysis. The MOF NH2-MIL-88B has shown potential use in cancer theranostics. Its open metal active sites catalyze the reduction...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Conroy Sun, Committee Member, representing School of Pharmacy

Nucleic Acid Based Therapeutics for Treatment of Cystic Fibrosis

Creator:: McKinney, Madison J.
Abstract:: Cystic fibrosis is an inherited genetic disease caused by a single gene mutation in the CFTR protein. Affecting 70,000 people worldwide, this disease is debilitating to patients, resulting in persistent lung infections and decreased quality of life. Due to the various mutation types, there is not currently a single drug...
Resource Type:: Honors College Thesis
Full Text:: Robinson. Dr. Conroy Sun provided in vivo lung biodistribution studies, paper was written by Ema

Incorporation of polymorphic spacers to inhibit sintering of SrO/SrCO3 for thermochemical energy storage

Creator:: Tran, Justin T
Abstract:: Global energy needs are continuously increasing while fossil fuels remain an uncertain resource. With a growing population and demand for energy, alternative energy sources are being pursued to power the future. Fossil fuels are an unsustainable resource that brings along problems of climate change and atmospheric pollution. Concentrated solar power...
Resource Type:: Honors College Thesis
Full Text:: increase efficiency in power generation and allow for generation beyond on-sun hours. One method of TES

Differential Binding and Structural Properties of the WWC Protein Family

Creator:: Rodriguez, Diego Javier
Abstract:: The WWC family consists of three proteins‐ KIBRA/WWC1, WWC2, and WWC3. The three proteins share a similar primary structure and interact with a common set of proteins. Each paralog contains two WW domains which recognize proline‐rich sequences of the type PPxY (P is proline, Y is tyrosine, x is any...
Resource Type:: Honors College Thesis
Full Text:: pathway (Chen and Liu, 2018; Han et al., 2018; Han et al., 2017; Hou and Zhou, 2017; Wennmann et al

Impact of Polycyclic Aromatic Hydrocarbons on Barrier Function Toxicity in 3D Lung Model from Normal and Asthmatic Donor Cells

Creator:: Huynh, Celine T.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are known to cause adverse health effects in the human lung. Here, we evaluated biomarkers relevant for PAH toxicity in a 3D human primary bronchial epithelial cell (HBEC) model collected from normal and asthmatic donors. We previously found that PAHs decrease cellular barrier function integrity, which...
Resource Type:: Honors College Thesis
Full Text:: interface. Toxicol Appl Pharmacol. 379:114644. doi:10.1016/j.taap.2019.114644. Chen M, Yang T, Meng X, Sun

Investigation of Magnesium Dioxybenzenedicarboxylate (Mg-DOBDC) Thin-film Deposition onto Modified Glass Substrates

Creator:: Haning, Evan J.
Abstract:: Metal-Organic Frameworks (MOFs) are crystalline compounds formed from reacting a metal ion with an organic ligand. They represent a promising new avenue in materials science for gas separations and storage. Certain MOFs, in particular Mg-MOF-74, have shown a strong affinity for the capture of CO2. This project investigated a known...
Resource Type:: Honors College Thesis
Full Text:: providing figures 2-8. I also thank Hao Sun for forming the foundation of this work, and for providing a

Estuaries in Motion : Teaching Estuarine Flow Concepts through Video

Creator:: Cameron, Marina R.
Abstract:: A short (approximately 8 minute) video was created to explain key concepts in estuarine flow and numerical modeling of estuaries for high school students. Animation, real picture videography, and numerical model outputs were used to illustrate how scientists use physics and physics models to understand how flow in an estuary...
Resource Type:: Honors College Thesis
Full Text:: forces of the sun and moon, tidal coefficients are calculated from the parameters of the celestial

Characterization of the SARS-CoV-2 Nucleocapsid Protein and the Binding to Different Sections of the SARS-CoV-2 Genome

Creator:: Pinckney, Seth H.
Abstract:: The nucleocapsid protein (N protein) of the severe acute respiratory syndrome coronavirus 2 is known to play an essential part of the virus’ functions. The N protein can protect and package the large 29,903 nucleotide genomic RNA whilst also interacting with structural membrane protein M and the spike protein S....
Resource Type:: Honors College Thesis
Full Text:: ., Sun, T., Yue, L., Peng, S., Chen, J., Li, G., Du, Y., Xie, Y., Yang, Y., Shen, J., Wang, Y., Shen, X

ScholarsArchive@OSU

State-of-the-Art Combination Therapies and Nanomedicines for Triple Negative Breast Cancer

Transcription Factors Associated with Tomato Seed Germination

Optimization of NH2-MIL-88B (Fe) for reactive oxygen species generation

Nucleic Acid Based Therapeutics for Treatment of Cystic Fibrosis

Incorporation of polymorphic spacers to inhibit sintering of SrO/SrCO3 for thermochemical energy storage

Differential Binding and Structural Properties of the WWC Protein Family

Impact of Polycyclic Aromatic Hydrocarbons on Barrier Function Toxicity in 3D Lung Model from Normal and Asthmatic Donor Cells

Investigation of Magnesium Dioxybenzenedicarboxylate (Mg-DOBDC) Thin-film Deposition onto Modified Glass Substrates

Estuaries in Motion : Teaching Estuarine Flow Concepts through Video

Characterization of the SARS-CoV-2 Nucleocapsid Protein and the Binding to Different Sections of the SARS-CoV-2 Genome

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