Honors College Thesis
 

Optimization of NH2-MIL-88B (Fe) for reactive oxygen species generation

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https://ir.library.oregonstate.edu/concern/honors_college_theses/vt150s19s

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  • Metal-organic frameworks (MOFs) have emerged as promising candidates in novel cancer therapies due to their unique properties, including high surface area, tunable crystal size, and exposed metal ion active sites for catalysis. The MOF NH2-MIL-88B has shown potential use in cancer theranostics. Its open metal active sites catalyze the reduction of H2O2 into reactive oxygen species (ROS) and act as a contrast agent for magnetic resonance imaging. This thesis focuses on optimizing NH2-MIL-88B's physical properties, specifically crystal size and exposed metal active sites, to maximize ROS generation and enhance cancer cell death through ROS-induced oxidative stress. Various synthesis routes were explored to consistently control crystal size and active site availability. ROS generation was evaluated through UV-Vis spectroscopy, using Crystal Violet (CV) degradation as an indicator. Decreasing crystal size was found to increase the rate of ROS generation. Reducing the amount of open metal active sites did not significantly affect ROS generation. These findings offer valuable insights into tailoring NH2-MIL-88B for future specific applications in cancer theranostics.
  • Keywords: Metal-organic framework, NH2-MIL-88B, Reactive oxygen species, Crystal violet
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