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  • Characterization of rodent selenoprotein W promoter

    Creator:
    Amantana, Adams
    Abstract:
    Rat selenoprotein W (SeW) promoter activity was investigated using different concentrations of cadmium, copper, and zinc. Two fragments (404bp and 1265bp) of the SeW promoter, containing a single metal response element (MRE), were ligated into the multiple cloning site of a pGL3-Basic reporter plasmid. The constructs were transfected into cultured...
    Resource Type:
    Dissertation
    Full Text:
    MRE sequence are critical to the metal induction of SeW promoter. The mechanism underlying this

  • Comparison of two methods for measuring erythrocyte aspartate aminotransferase activity in humans

    Creator:
    Iwakiri, Yasuko
    Abstract:
    We compared a kinetic method (KM) and a colorimetric method (CM) for measuring erythrocyte aspartate aminotransferase (EAST) activity. Twenty-three healthy college students including 7 men and 16 women, aged from 22 to 40 years, participated in this study. Vitamin B-6 status was assessed by EAST activity coefficient (EAST-AC), the ratio...
    Resource Type:
    Masters Thesis
    Full Text:
    al., 1985). Following phosphorylation, PNP and PMP are oxidized to PLP by the action of PN (PM) S

  • Transcriptional repression mediated by a novel family of C₂H₂ zinc finger proteins

    Creator:
    Senawong, Thanaset
    Abstract:
    Two novel and highly related C₂H₂ zinc finger proteins (CTIP1/BCL11A/EVI9 and CTIP2/BCL11B/Rit1) have been implicated in COUP-TF signaling, etiology of myeloid and lymphoid malignancies, and hematopoietic cell development. However, the precise cellular function(s) and the contribution of these proteins to neoplastic processes and hematopoietic cell development remain unknown. The goal...
    Resource Type:
    Dissertation
    Full Text:
    catalyzed by member(s) of class I and II HDACs. One possible mechanism is that CTIP proteins may exert ISA