The mechanisms by which the activities of phospholipase C-β (PLC-β) enzymes are negatively regulated have not been well defined. We used cardiac-derived ratmyoblast H9c2 cells to investigate possible modes of regulation of PLC-β3 enzymes,the only endogenous β isoform abundantly found in these cells. The PLC-β3population in these cells was detected...
SAR11 Alphaproteobacteria are the most abundant aerobic chemoheterotrophs in ocean surface waters. Previous studies have indicated SAR11 cells play an important role in marine carbon cycling and consume up to half of some common dissolved organic compounds, such as amino acids. During sequencing of the first SAR11 genome, genes for...
This dissertation presents a phase domain in-loop-bandwidth spread-spectrum clock generation technique. In this proposed technique, a charge-based discrete-time loop filter is proposed to enable the phase domain in-loop-bandwidth spread-spectrum modulation without a delta-sigma modulator or time-to-digital converter. The in-loop-bandwidth modulation technique maximizes the loop bandwidth to improve phase noise suppression...
Metal-organic frameworks (MOFs) have emerged as promising candidates in novel cancer therapies due to their unique properties, including high surface area, tunable crystal size, and exposed metal ion active sites for catalysis. The MOF NH2-MIL-88B has shown potential use in cancer theranostics. Its open metal active sites catalyze the reduction...
The aim of this work was to assess the viability of duplex stainless steel 2205 components built via selective laser melting for seawater applications. First, a comprehensive additive manufacturing assessment was done. The duplex stainless steel 2205 components were selectively laser melted from gas atomized powder (D90 <45m) using a...
Heat-related fruit damage is a common problem in the northern highbush blueberry (Vaccinium corymbosum L). This is particularly true in regions such as the northwestern United States, where summers are warm and dry, and daytime temperature regularly exceeds 32 oC. Millions of dollars of fruit damage are reported in blueberries...
A low-voltage plateau at ∼0.3 V is discovered during the deep sodiation of Na₃V₂(PO₄)₃ by combined computational and experimental studies. This new low-voltage plateau doubles the sodiation capacity of Na₃V₂(PO₄)₃, thus turning it into a promising anode for Na-ion batteries.
Drosophila suzukii Matsumura (Diptera: Drosophilidae) are small invasive flies that in the past five years (2009-2014) invaded berry and stone fruit production regions in Europe and the Americas. Evolutionary adaptations, biological traits, and anthropogenic factors have contributed to its current status as a global pest. Females oviposit eggs into ripe...
The bimolecular reaction of two carbenoid species resulting in the formation of a carbon-carbon double bond (pi-system), referred to herein as carbenoid eliminative cross-coupling (CEXC), involves a series of three fundamental steps: (i) ate-complex formation (transmetalation), (ii) 1,2-metalate rearrangement, and (iii) beta-elimination. All three steps are stereospecific and so the...
The integration of low-pressure membrane filtration and aerobic granular sludge (AGS) reactor leads to a novel environmental biotechnological process with strong potential to overcome membrane fouling and demonstrate excellent wastewater treatment performance. However, membrane fouling mechanisms in the AGS based membrane bioreactor (MBR) are lack of systematic elaboration. In the...