Miniaturized and portable microfluidic analytical platforms have been widely explored in the broad field of chemical analysis. The concept of microfluidics offer a number of important advantages, including low reagent consumption, low-cost detection, high sample throughput, and shorter analysis time. Semiconductor nanocrystals or quantum dots have been extensively utilized in...
Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...
Polyoxometalates are discrete anionic oxo clusters of the Group V and VI transition metals that can be conceptualized as molecular metal oxides. Because they are pairable with any alkali cation, a great deal of fundamental chemistry can be gleaned from their study, including solubility trends and insight into cation binding...
The goals of this dissertation are centered on understanding changes in Earth surface and climate systems through the use of geologic proxies as records of past changes in these systems. Specifically, this dissertation (1) establishes a new chronology for retreat of the Ross Sea sector of the West Antarctic Ice...
The Lena River in central Siberia is one of the
major pathways translocating terrestrial organic matter (OM)
from its vast catchment area to the coastal zone of the Laptev
Sea and the Arctic Ocean. The permafrost soils of its far
south-stretching catchment, which store huge amounts of
OM, will most...
The Lena River in central Siberia is one of the
major pathways translocating terrestrial organic matter (OM)
from its vast catchment area to the coastal zone of the Laptev
Sea and the Arctic Ocean. The permafrost soils of its far
south-stretching catchment, which store huge amounts of
OM, will most...
Full Text:
– Part 2: Lignin-derived
phenol compositions
Winterfeld, M., Goñi, M. A., Just, J., Hefter, J
The goal of dissertation research was to use geochemical, statistical and geological methods to constrain and understand climate variability over several different time scales. Specifically, I have addressed three questions regarding past climate change: (1) how does the record of Irish cirque glaciers constrain the dimensions of the Irish Ice...
The Lena River in central Siberia is one of the
major pathways translocating terrestrial organic matter (OM)
from its vast catchment area to the coastal zone of the Laptev
Sea and the Arctic Ocean. The permafrost soils of its far
south-stretching catchment, which store huge amounts of
OM, will most...
Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...