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Filtering by: Creator Ashley, Carol Ann Subject Acetaminophen -- Controlled release

Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

Creator:

Keller, Carol Ann

Abstract:

Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses...

Resource Type:

Dissertation

Full Text:

Carol Ann Keller A THESIS Submitted to Oregon State University in partial fulfillment of the