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Filtering by: Subject Dolphins -- Therapeutic use Subject Acetaminophen -- Controlled release

Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

Creator:

Keller, Carol Ann

Abstract:

Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses...

Resource Type:

Dissertation

Full Text:

chronic use of high doses of acetaminophen are associate with hepatic toxicity. These research was
A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

Creator:

Rakkanka, Vipaporn

Abstract:

This thesis describes evaluation of a novel self-sealing chewable sustained release tablet that can maintain controlled release of drug regardless of compaction, crushing, or chewing. The new formulation contains polyethylene oxide which produces a sealant effect for cracks produced in the polymer coating during compaction. Dissolution studies were conducted and...

Resource Type:

Dissertation

Full Text:

liquid formulation but without the use of cyclodextrins. New itraconazole liquid formulations were