Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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. Bhat, Jeff M. Blaney, Evan Bolton, Gerard Bricogne, David
Brown, StephenK. Burley, David A. Case, Kirk
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Full Text:
Bolton,9 Gerard Bricogne,10 David Brown,11,12 StephenK. Burley,5,6,13,* David A. Case,6
Kirk L. Clark
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
The preservation of land, such as wetlands and agricultural
lands, is often pursued through traditional methods such as zoning or
eminent domain. Transferable Development Rights provides a different
approach to the preservation of land by allowing the sale and transfer
of development rights from land to be protected to land...
The influence of overstory openness on the reproductive
ecology of Pacific yew (Taxus brevifolia Nutt.) was
investigated on 4 sites in western Oregon over 2 years. The
breeding system of T. brevifolia was found to deviate from
pure dioecy under a broad range of canopy and site
conditions. Production of...
Anchors resistant to tensile loads are commonly used in civil engineering practice. Anchors in the marine environment are most frequently used for the mooring of vessels. Only recently, with the expansion of the offshore industry, has the need to develop more reliable anchor systems become necessary. Embedded plate anchors are...
The use of electronic cigarettes (often referred to as vapes or e-cigs) has grown rapidly in the past decade. While these devices may not deliver the same level of carcinogens and toxicants as combustible cigarettes, they can deliver nicotine (a known developmental toxicant) as efficiently. Previous work suggests that, during...
The Soil Conditioning Index (SCI) aids the conservationist in designing crop rotations and residue management practices when low organic matter, poor soil tilt, and crusting problems are identified. The Natural Resources and Conservation Services (NRCS) field staff and others use the SCI as a qualitative tool during conservation planning. In...
The heritability of resistance to eastern filbert blight, caused by Anisogramma anomala, in European hazelnut (Corylus avellana) was evaluated in the progeny of seven cultivars crossed in 12 combinations. Progeny produced by crossing 'VR6-28' with three susceptible cultivars segregated 1:1 for complete resistance to eastern filbert blight. Histograms of disease...
Interactions between proteins and contact surfaces can have
important implications in the food industry. Such interactions
contribute to the course of fouling of membrane surfaces and they
appear to mediate bacterial and spore adhesion to some degree as
well. In addition to protein and solution properties, interfacial
behavior is strongly...
'Alba' (Reg. No. [CV-355, PI 672535]) is a winter, six-row barley released by the Oregon Agricultural Experiment Station in 2012. The name “Alba” was chosen due to the bright and attractive appearance of the crop at maturity. In high rainfall environments, it has a notable yield advantage over check varieties...
Flavin-containing monooxygenase (FMO) oxygenates drugs/xenobiotics containing a
soft nucleophile through a C4a hydroperoxy-FAD intermediate. Human FMOs 1, 2 and
3, expressed in Sf9 insect microsomes, released 30-50% of O₂ consumed as H₂O₂
upon addition of NADPH. Addition of substrate had little effect on H₂O₂ production.
Two common FMO2 (the major...
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Hydrogen Peroxide
Siddens, L. K., Krueger, S. K., Henderson, M. C., & Williams, D. E. (2014).
Mammalian
Sulfur is one of the six elements required during the early stages of the evolution of life, and enzymes involved in sulfur transfer and oxidation are increasingly being recognized as potential drug targets for antimicrobials as well as for therapies for cancer, neurodegenerative and inflammatory diseases. Bacteria are able to...
Douglas-fir (Pseudotsuga menziesii) has a wide distribution in North America and is one of the
tree species most widely distributed outside its natural range. The species has been introduced to
Europe, New Zealand, South America, and elsewhere around the world. At present, Douglas-fir
is an accepted and integral part of...
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Douglas-fir
Denis P. Lavender and Richard K. Hermann
The
Douglas-fir (Pseudotsuga menziesii) has a wide distribution in North America and is one of the
tree species most widely distributed outside its natural range. The species has been introduced to
Europe, New Zealand, South America, and elsewhere around the world. At present, Douglas-fir
is an accepted and integral part of...
Full Text:
Douglas-fir
Denis P. Lavender and Richard K. Hermann
The
Responses to two cycles of mass selection for heading date,
followed by selfing or intermating, were studied in two diverse
winter wheat (Triticum aestivum L. em. Thell) crosses. Selection
was bidirectional, resulting in early and late populations for
each mating system, cycle, and cross. The influence of mass
selection for...
The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...