High-resolution infrared absorption spectra have been analyzed for two bicyclo[111]pentane isotopologues, C₅H₈ (-d₀) and C₅H₇D (-d₁), where in the latter the D-atom replaces a hydrogen on the C₃ symmetry axis such that the molecular symmetry is reduced from D₃ₕ to C₃ᵥ. Two (a"₂) parallel bands, v₁₇ and v₁₈, of bicyclopentane-d₀...
This paper is a continuation of earlier work in which the high resolution infrared spectrum of [1.1.1]propellane was measured and its k and l structure resolved for the first time. Here we present results from an analysis of more than 16,000 transitions involving three fundamental bands v₁₀ (E' - A'₁),...
The photoelectron spectra of a series of halogenated
molecules have been investigated in the gas phase. Both
core-ionization energies and Auger kinetic energies were
measured to probe the nature of the interaction that holds
a core electron to the molecule.
It was found that satellite structure (shake) could be
used...
Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes 2 the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. 3 One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active 4 site, but quantum mechanical calculations have been used...
Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes 2 the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. 3 One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active 4 site, but quantum mechanical calculations have been used...
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, Corvallis, OR 97331 8
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Department ofMolecular Medicine, 618 Tower Rd, Cornell University, Ithaca, NY
Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes 2 the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. 3 One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active 4 site, but quantum mechanical calculations have been used...
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is weaker than that of the Cys93 Sγ, consistent with the iron having 5
decreased occupancy. We
A variety of laser spectroscopic methods are employed in this
thesis research for studies of CF₃NO, an interesting model
photodissociative system, and for investigation of low energy rotations
and vibrations of small molecules and low molecular weight clusters in
free jet expansions.
Nonradiative energy decay for electronically excited CF₃NO is...
A high-spectral resolution laser-excited molecular fluorescence
system was developed that utilizes a pulsed supersonic expansion to
simplify the fluorescence excitation spectra of large, gas-phase
aromatic molecules diluted in an excess of a monatomic gas. A
microcomputer was used to control and synchronize the instrumental
components, which included a Chromatix CMX-4...
A new experimental apparatus was built at Oregon State University to perform high resolution stimulated Raman spectroscopy in a pulsed molecular jet at state densities of the order of 10¹¹ cm⁻³. The technique uses a stimulated Raman step to first populate a vibrational/rotational level and then a resonantly enhanced multiphoton...
RNA silencing is an evolutionarily conserved system that
functions as an antiviral mechanism in higher plants and
insects. To counteract RNA silencing, viruses express
silencing suppressors that interfere with both siRNA- and
microRNA-guided silencing pathways. We used comparative
in vitro and in vivo approaches to analyse the molecular
mechanism of...
The capabilities of the Tektronix Model J2C/7J20 Rapid Scanning
Spectrometer for the determination of molecular species resulting from
Otto cycle combustion were experimentally investigated after a literature
search of the subject area. Combustion of hydrogen-air, carbon monoxideair,
and gasoline-air mixtures in the combustion chamber of a Cooperative
Fuel Research engine...
Two nonlinear optical experiments are presented in which the third-order electronic susceptibility of molecules is used to generate Raman signals. The first one uses a single 532 nm beam from a Nd:YAG laser to produce Stimulated Raman Scattering in benzene and deuterated benzene. With a simple experimental set-up, stimulated emission...
There is increasing evidence that aging is affected by biological (circadian) clocks – the internal mechanisms that coordinate daily changes in gene expression, physiological functions and behavior with external day/night cycles. Recent data suggest that disruption of the mammalian circadian clock results in accelerated aging and increased age‐related pathologies such...
Background: Considering the pharmacokinetic and pharmacodynamic aspects of different medications, it is plausible that the age of a smoker could affect the half-life of these drugs. The aim of this study was to compare the effectiveness of smoking cessation drugs (nicotine replacement therapy, bupropion, and varenicline) used either in isolation...
The temporal and spatial characteristics of a laser microprobe plume were investigated using the spectroscopic methods of emission, absorption and fluorescence. The plume was produced by rapid vaporization of a small quantity (1 μg) of a solid sample using a focussed pulsed dye laser (110 MW/cm²). For absorption and fluorescence...
The interaction of lecithin-cholesterol acyltransferase (LCAT) with apolipoprotein A-I (apoA-I) plays a critical role in highdensity lipoprotein (HDL) maturation.Wepreviously identified a highly solvent-exposed apoA-I loop domain (Leu¹⁵⁹–Leu¹⁷⁰) in nascent HDL, the so-called “solar flare” (SF) region, and proposed that it serves as an LCAT docking site (Wu, Z., Wagner, M....
A new x-ray source capable of operating at up to 80
watts has been designed and developed, and put to use with
the Oregon State University Cylindrical Electrostatic
Analyzer. The new source produces over four times the
photoelectron intensity of its predecessor, from gaseous
samples, and accommodates a wider selection...
Cadmium is a common impurity in phosphatic fertilizers and may contribute to soil Cd accumulation. Changes in total and bioavailable Cd burdens to agricultural soils and the potential for plant Cd accumulation resulting from fertilizer input was investigated. Three year field studies were conducted using three dose levels of cadmium-rich,...