Nitrate concentrations, chlorophyll a (Chl a) fluorescence, radiance, salinity, and
temperature were measured on the Hawaii Air-Sea Logging Experiment, A Long-Term
Oligotrophic Habitat Assessment (HALE ALOHA) mooring located near the Hawaii
Ocean Time-Series (HOT) Program’s Station ALOHA (22°45’N; 158°W). Nitrate
concentrations were determined with OsmoAnalyzers deployed at depths of 120...
Conservation conflicts may develop on restoration sites with multiple species recovery objectives. For example, on Pacific Northwest prairies, the co-planting of the diploid cytotype of the common native wildflower Castilleja hispida with the endangered wildflower C. levisecta has resulted in putative Castilleja hybrids on restoration sites, prompting fears that genetic...
Lycopodium alkaloids have shown widespread and noteworthy biological activity, consisting of over 250 known natural products. Moreover, their structural complexity and diversity have attracted considerable attention from numerous laboratories including our own. Recently, we have developed a unified approach that would provides access to numerous, previously unprepared C₁₀-functionalized lycopodium alkaloids....
The increasing knowledge of the significance of vitamin B₆ in
human metabolic processes has emphasized the importance of developing
reliable means of assessing nutritional status with respect to
this vitamin. One possible approach to this end is the measurement
of pyridoxal phosphate in blood or plasma, particularly since this
phosphorylated...
Two novel and highly related C₂H₂ zinc finger proteins (CTIP1/BCL11A/EVI9 and CTIP2/BCL11B/Rit1) have been implicated in COUP-TF signaling, etiology of myeloid and lymphoid malignancies, and hematopoietic cell development. However, the precise cellular function(s) and the contribution of these proteins to neoplastic processes and hematopoietic cell development remain unknown. The goal...
This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
The Whale Cove Site, 35LNC60, is a shell midden, showing
occupations from 3010 B.P. to 330 B.P., spanning the Early and Late
Littoral Periods. Analysis of mammalian faunal remains, bone and
antler tools, lithics and discriptions of recovered shellfish
artifacts allows for chronological refinement of the previously
mentioned archeologically defined...
To determine if 6 weeks prior supplementation with vitamins E and C
could alleviate exercise-induced DNA damage, prevent lipid peroxidation and
inflammation, slow the rate of vitamin E utilization and/or attenuate muscle
damage, 22 subjects (11 females: 11 males) were studied during a 50 km (32
mile) ultramarathon. Subjects were...