Acute myeloid leukemia (AML) is a blood malignancy characterized by a differentiation and proliferation defect of myeloid progenitors leading to accumulation of myeloid blasts. It is one of the most common leukemias in adults. Trametinib (Mekinist) is a small molecule inhibitor that targets MEK1 (MAP2K1) and MEK2 (MAPK2K2). It has...
Selenium deficiency in rats results in increased carbon metabolism,
approaching twice the rate of selenium supplemented animals
(normal). This is also reflected in a 50 percent increase in lysosomal
enzyme activity in tissues of selenium deficient animals.
Isolation of rat liver lysosomes shows a 17 percent increase in
membrane thickness...
This dissertation describes studies of isoprenoid biosynthesis in the
phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known
mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
Chlorpyrifos (CPF) is a widely used broad-spectrum organophosphate insecticide. Following exposures, CPF and its more toxic oxon metabolite (CPFO) elicit neurotoxic effects by inhibiting the activity of the acetylcholinesterase enzyme (AChE), resulting in altered fitness and death at high doses. Following exposure, organisms bioactivate CPF to CPFO through the Cytochrome...
In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...
A time dependent model of the shallow, tropical convective boundary layer is
developed and tested. To simplify the treatment of thermodynamic processes and
return to first principles of physics, conserved quantities of entropy and total
water density are used as primary model variables. In addition, a new shallow
cumulus parameterization...
The primary objective of this thesis is to develop a process for fabricating integrated circuits based on thin-film transistors (TFTs) using zinc tin oxide (ZTO) as the channel layer. ZTO, in contrast to indium- or gallium-based amorphous oxide semiconductors (AOS), is perceived to be a more commercially viable AOS choice...
The purpose of this work was to design a system for measuring
the velocity of a powder actuated fastener or drivepin during penetration.
This system would provide a tool for further investigation
into drivepin penetration characteristics. The main characteristic
of interest is the instantaneous acceleration from which the forces
on...
This study was conducted to investigate the involvement of selenium and glutathione peroxidase in
prostaglandin biosynthesis by the ram vesicular gland.
Vesicular glands were collected from healthy intact
rams covering a wide range of selenium nutrition and were
analyzed for selenium concentrations, glutathione
peroxidase activities and levels of prostaglandin E₂...
The momentum transfer characteristics of liquid-liquid dispersions
were studied under conditions of turbulent flow in a cirular
conduit. Experiments were conducted to obtain drop size, friction
factors and velocity profiles for three organic phases dispersed in
water.
The test sections consisted of straight copper tubes 1-inch OD
and 0.830-inch ID....