Three studies were conducted to determine the effects of
cyclopropenoid fatty acids (CPFA) on the membrane components of livers
of rainbow trout (Salmo gairdneri). In the first study, ¹⁴C-sterculic
acid was administered by intraperitoneal injection into rainbow trout
and the trout maintained for 72 hours. The labelled sterculic acid
was...
Biliary excretion of taurocholate in thermally acclimated rainbow trout was stimulated at higher environmental temperature (18 vs. 14 or 10° C)e Acute 4° C shifts in body temperature produced more pronounced changes in biliary excretion. Thermally modulated biliary excretion was negatively correlated with plasma half live of taurocholate. Absorption of...
Clinical methods to diagnose specific organ dysfunction have not been evaluated in fishes. To determine if an accepted clinical test of mammalian liver function could be applied to fishes, the
hepatic disposition of the organic anion sulfobromophthalein (BSP) was studied in rainbow trout (Salmo gairdneri) treated with a model hepatotoxicant....
The rainbow trout (Oncorhynchus mykiss) model
of chemical carcinogenesis is becoming increasingly
important as a supplement to rodent studies. However,
much of the molecular biology of the carcinogenic
response is still unknown in the trout model. The ras
gene family has been implicated in the tumorigenesis of
both spontaneous and...
Previous reports indicate the presence of multiple CYP1A sequences in rainbow
trout, but their functional differences are unknown. This report describes the cloning and partial characterization of four trout CYP1A cDNAs, which are given the tentative
designations CYP1A1v2, v3, v4, and v5. Comparison among these four and three
previously reported...
Changes in blood calcium and phosphorus concentrations were
characterized for rainbow trout (Salmo gairdneri) and coho salmon
(Oncorhynchus kisutch) following intense exercise or exposure to
suspended volcanic ash or topsoil. Significant elevations in blood
calcium and phosphorus accompanied exercise-induced acidemia in both
S. qairdneri and O. kisutch. These elevations persisted...
Temperature influences the incidence of chemically induced cancer in fish,
with warmer temperatures being associated with higher cancer incidence. The
mechanisms of temperature-modulated chemical carcinogenesis in fish, however,
have not been described in detail. Therefore, one primary objective of this study
was increased understanding of how temperature-modulated genotoxicity of 7,12-...
A dietary level of Aroclor 1254 (100 ppm) was fed to rainbow trout (Salmo gairdneri) for 15 weeks to determine the effects on hepatic microsomal enzyme induction. Fish were also fed combined polychlorinated biphenyl (PCB) (100 ppm) and cyclopropene fatty acids (CPFA) (50 ppm) to determine the effects on mixed...