Alzheimer’s Disease (AD) is an abnormal part of aging that mainly affects those over the age of 65. The current therapies are only FDA approved for mild to moderate AD symptoms. Cannabidiol (CBD) is a non-intoxicating constituent of Cannabis sativa that has been shown to have beneficial effects on cancer,...
Metabolomics has recently gained momentum in biomolecule research and complements the genomics and proteomics research space. Metabolomics strives to detect, identify, and quantify all metabolites present in biological samples. In particular, biomolecular analysis using ultra-performance liquid chromatography combined with mass spectrometry (UPLC-MS) has become increasingly important for metabolomic analyses. Similarly,...
Desferrioxamine B (DFOB) was reversibly and covalently conjugated to polystyrene microspheres via N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP) crosslinker. DFOB retained post-immobilization activity with at least 89% able to bind Fe(III)-citrate under pH 7.4 and a citrate:iron molar ratio = 100:1. Comparing iron capture by DFOB-activated beads and sulfhydryl (−SH) control beads demonstrated...
This research presents a u-channel based study of the natural remanent magnetization (NRM), the laboratory magnetization, Anhysteretic Remanent Magnetization (ARM), and magnetic susceptibility (k), from the upper 100 m of International Ocean Discovery Program (IODP) Expedition 383 Site U1543 in the eastern South Pacific sector of the Southern Ocean. Alternating...
Global environmental change is causing local extinctions of species. When species depend on one another, as in the mutualistic relationship between plants and pollinators, loss of one interaction partner may cause cascading effects within the community – such as additional extinctions and reduced pollination services. Network theory provides a way...
Magmatic-hydrothermal ore deposits are giant geochemical anomalies in the earth’s crust most often generated by normal magmatic terrestrial processes. They are often associated with oxidized and hydrous intermediate to highly evolved magmas that have concentrated metals and have the necessary components to efficiently extract and transport them as ascending magmatic-hydrothermal...
Polycyclic aromatic hydrocarbons (PAHs) are complex mixtures that form when organic matter is burned. Humans are primarily exposed to PAHs via air pollution from incomplete combustion of fossil fuels and biomass, such a motor vehicle exhaust, cigarette smoke, wood smoke, or industrial emissions; or via ingestion of PAHs bound to...
Critical Infrastructures (CIs) such as energy, water supply, telecommunications, and transportation are highly vulnerable to cascading failures due to their interdependent operations. A resilient network is crucial to withstand the impact of functionality loss in disruptive events. This research evaluates network expansion as a proactive resilience strategy in which new...