Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the...
Full Text:
: 10.1038/srep21243
Y chromosomes and mitochondria were removed from the initial statistical analysis. Only
Academic success is a salient domain of youth development and is related to positive lifelong outcomes among youth in foster care. However, youth in foster care experience compounding adversities, including maltreatment and foster care placement itself, which put them at risk of academic disengagement and underachievement. Despite these adversities, academic...
In the Pacific Northwest, several species of rockfishes (Sebastes spp.) are under extreme conservation measures due to low population levels. Although currently at healthy population levels, one species of interest is the black rockfish (S. melanops), which has been shown to utilize estuarine habitat during its early life history stages....
The purpose of this thesis is to identify the issues relating to body image in young adult breast cancer survivors, and to observe which physical issues are related to which psychological issues. Participants were recruited through Army of Women and through social media. The study partcipants were 29 English-speaking female...
Human alterations of landscapes take many forms, one of which is anthropogenic pollution. Mercury (Hg) is a complex contaminant because its uptake into the food web is not driven entirely by loading to the system; methylation is necessary to make Hg bioavailable and toxic to fish and wildlife. Because methylation...
The sagebrush steppe ecosystem of the northern Great Basin is severely degraded and continues to decline due in large part to the invasive, non-native annual grasses Bromus tectorum L. (cheatgrass) and Taeniatherum caput-medusae (L.) Nevski (medusahead). Restoration of invasive-dominated areas is difficult, but can be enhanced by adding a carbon...
Early ocean residence is assumed to be a critical period for juvenile Pacific salmon Oncorhynchus spp. However, the specific mechanisms influencing growth and survival in the ocean have not been identified for most populations. Therefore, three hypotheses regarding the relationship between early marine residence and subsequent survival of mid-upper Columbia...
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Jessica A. Miller
Early ocean residence is assumed to be a critical period for juvenile
Oregon's estuaries are important ecosystems for scientific study. Consequently, knowledge of what research has been conducted helps us identify benchmarks and plan new projects. A comprehensive bibliography of published research, technical reports, local documents, and data sets is one means of recording this knowledge. For these reasons, the Guin Library...
Several dolphin species have global distributions. The extent of their radiation and limits to gene flow are presumably a product of oceanographic features both recent and historical, behavioral specializations and social organization. Rough-toothed dolphins (Steno bredanensis) are globally distributed in tropical and subtropical waters and are generally found in depths...
Generally presented as a preferred social norm based on both ethical considerations and legislative demands, gender equality has been highly encouraged in recent years. For instance, The United Nations Sustainable Development Goals for 2030 call out achieving gender equality and empowerment of women. However, although there are multiple efforts to...
An interpretative philosophical framework was applied to a case study to document the particular experiences and perspectives of ten women engineering transfer students
who once attended a community college and are currently enrolled in one of two university
professional engineering programs. This study is important because women still do not...
Throughout society, many believe women are not succeeding professionally because of the institutional barriers created by men in the American workforce. However, women may be more competitive with other women than with men, especially when limited job positions are the goal. Competitiveness among women can be explained by a phenomenon...
This thesis is a report of a phenomenological-informed study of public university student spiritual development. The research was based primarily upon semi-structured personal interviews and a focus group with undergraduate students at a large, public research institution on the west coast. Since the introduction of scientific objectivity into the academy...
The southwest monsoon, which may be idealized as the northward movement of the intertropical convergence zone in the Indian Ocean associated with differential heating of land and ocean, brings a seasonal reversal of currents and winds in the Bay of Bengal and the Arabian Sea. Atmospheric convection from monsoon activity...
With continual and worldwide human population growth, our impact on the natural environment expands and intensifies every day. We consume natural resources, burn fossil fuels, and release toxic compounds into the air, water, and earth. We build roads that fragment the landscape, construct new settlements, and develop agricultural lands in...
There has been much discussion in the conservation and policy realms of COVID-19 as a zoonotic disease, or a disease transmitted from wildlife to humans. However, wildlife consumption in China is not only a potential source of disease but also a practice embedded in complex beliefs about health. This paper...
The purpose of this study was to explore motivations behind participation in cosplay and the use of social media among cosplayers who maintain Facebook Artist Pages. Further focus was placed on investigating the role of Facebook Artist Pages in building fame. To explore such motivations, two theories were referenced: Deci...
The Pigeon Guillemot (Cepphus columba) is now the only species of marine bird in Prince William Sound (PWS), Alaska that is listed as "not recovering" on the Exxon Valdez Oil Spill (EVOS) Trustee Council's Injured Resources List and has shown no sign of population recovery. During the 20 years since...
This research examines two questions: 1) What stories do Christian teacher educators tell about their own White racial identity development? and 2) Is there an impact of studying White racial identity development on the praxis of Christian teacher educators? If so, in what ways? The researcher began the project with...
Early ocean residence is considered a critical period for juvenile salmon although specific survival mechanisms are often unidentified and may vary by species or life stage. Columbia River spring-run Chinook salmon Oncorhynchus tshawytscha abundance has declined dramatically since the early 1900s. To elucidate mechanisms of early marine survival, we tested...
It is not unusual to see stranded or washed-up marine animals and birds along any
coastline. Various networks nationwide exist to report marine mammals and sea birds,
yet, we have been unable to find a network in Oregon or nationally to report other
stranded marine animals, namely fish, cephalopods, and...
Urban African American adolescents exhibit high levels of risk behavior, disproportionately high rates of sexually transmitted infections (STIs), and are at risk for acquiring Human Immunodefiency Virus (HIV). To date, interventions that address the high rates of STIs in this population demonstrate only moderate efficacy. As researchers strive to develop...
The purpose of this thesis is to understand the experiences that Nahua children, in rural Mexico, have as they attend schools that are primarily influenced by formal Western education in relation to their own ways of learning and knowing. This research took place over the course of three months within...
Proceedings of the 77th Annual Western Orchard Pest and Disease Management Conference, held January 15-17, 2003 at the Hilton Portland in Portland, Oregon.
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease where paralysis of the body is the result of motor neuron function loss. A potential cause of ALS is the loss of zinc from Superoxide Dismutase (SOD). SOD’s cellular responsibility is to enzymatically react with the superoxide anion forming oxygen and the...
Cover crop establishment in late-season crops, like sweet corn, may be difficult due to the relatively short operational window following crop harvest. In regions like western Oregon, where fall-precipitation can occur when the crop is still in the field, cover crops may not be able to be planted, due to...
Weed interference is a major, ongoing pest problem in sweet corn and a diverse community of weeds persists until harvest in most fields. Impact herbicide was used for the first time in 2006 with great success, and a registration for Laudis was granted in November of 2007. These registrations have...
Efficient time-series analysis can impact multiple application domains such as motif discovery in gene analysis or music data, extracting spectro-temporal patterns in acoustic scene analysis, or annotating and classifying electrical bio-signals (such as ECG, EEG, and EMG) for medical applications.
Time-series analysis involves a variety of tasks.
To predict future...
In this dissertation I explore the Arms representation and activities for teaching quantum mechanics invented at Oregon State University. In the Arms representation students embody quantum states. The Arms activities are presented as an exemplar of the unique physics classroom culture of the upper-division Paradigms in Physics program. In the...
Published March 1990. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Springs in arid lands provide critical habitat for a variety of species and functions to humans, yet the ecology and management needs of springs to maintain these values are poorly understood. To examine plant communities along spring watercourse-upland gradients, we sampled 12 springs at low (desert) and high (forest) elevations...
Microbial ecology has been transformed by metagenomics, the study of the genetic in-formation in entire communities of organisms. In the following we develop metagenomic tools arising from the classic Wasserstein metric as applied to questions regarding the diversity between microbial communities. We provide a novel proof of the characteriza-tion of...
Ocean acidification is a global, long-term problem whose ultimate solution requires carbon dioxide reduction at a scope and
scale that will take decades to accomplish successfully. Until that is achieved, feasible and locally relevant adaptation and
mitigation measures are needed. To help to prioritize societal responses to ocean acidification, we...
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, Linwood H. Pendleton4,5, George G. Waldbusser6,
Josh E. Cinner7, Jessica Ritter8, Chris Langdon9, Ruben
The global mid-ocean ridge system is the largest magmatic system encompassing over 75% of the Earth’s total volcanism. As magmas ascend through the vertically variable oceanic crust, melts begin to crystallize and diversify and subsequently erupt at the surface. The interpretation of these erupted products observed on the seafloor requires...
This issue is packed with information. James Osborne, Enology Extension Specialist, OSU, opens the newsletter with an article about managing Brettanomyces and spoilage in the winery. Patty Skinkis, Viticulture Extension Specialist, OSU, provides an article on the challenge of yield estimation in vineyards. Jay Pscheidt, Extension Plant Pathologist, OSU, provides a timely article on scouting for crown...
Dietary intake data of 15 treated patients with
phenylketonuria (PKU) (7-17 years) and six control siblings
(6-14 years) were used to evaluate the effectiveness of
medical foods to balance energy, protein, vitamin B-6, and
individual amino acids from natural foods and to evaluate
vitamin B-6 status. Four-day diet records were...
Cold air pools are spatiotemporal phenomena that occur when cold air from higher elevations roll down the slope to accumulate in lower elevations. Behaviors like this lead to microclimate anomalies such as the city of Corvallis (Oregon) experiencing persistent cold weather even on a sunny day. We analyze multivariate temperature...
Learning to recognize objects is a fundamental and essential step in human perception and understanding of the world. Accordingly, research of object discovery across diverse modalities plays a pivotal role in the context of computer vision. This field not only contributes significantly to enhancing our understanding of visual information but...
OBJECTIVE: In this study, we examined how effectively
people can monitor new stimuli on a peripheral display
while carrying out judgments on an adjacent central display.
BACKGROUND: Improved situation awareness is critical
for improved operator performance in aviation and many
other domains. Given the limited extent of foveal processing,
acquiring...
Scholars promote the ability of visual imagery to have a number of political campaigning benefits such as influencing opinions and attitudes and encouraging vibrant, striving democracy while improving the quality of public knowledge and opinion. However, previous research on this subject has failed to identify how presidential candidates display their...
Higher education literature lacks frameworks and models that consider women of color mentoring and fewer that discuss virtual mentorship among women of color. This work examined a successful and productive virtual mentorship and explored the key features of the mentorship, how the mentorship was maintained virtually, and the benefits and...
The objectives of this study are to determine:
· How vine vigor and fruit composition vary in different alleyway management regimes: solid vegetative cover vs. every other alleyway of vegetative cover removed
· What differences are observed in different alleyway management regimes within a vineyard
· What differences are observed...
This thesis consists of two major components. The first part is concerned with video object instance segmentation (VOS), which is the task of assigning per-pixel labels perframe of a video sequence to indicate foreground object instance membership, given the first frame ground truth mask. VOS has myriad applications, from video...
Differences in the chemical composition of calcified structures can be used to reveal natal origins, connectivity, metapopulation structure, and reconstruct the environmental history or movement patterns of many marine organisms. Sharks, skates, and rays (elasmobranchs) lack the calcified structures, known as otoliths, that are typically used for geochemical studies of...
Jointed goatgrass (Aegilops cylindrica Host) infestations in winter wheat (Triticum aestivum L.) production regions of the central and western USA result in severe economic losses in the wheat market. Field and greenhouse studies were conducted to determine the vernalization requirements of winter wheat, spring wheat, jointed goatgrass, and wheat by...
The internationalization brought about by online finding aids and the United States’ expanding diverse population necessitates a renewed focus on representation and accessibility in archival research. The accessibility of archival resources depends on the language in which the content is offered to the public. Throughout the United States, the Spanish-speaking...
As scientists, we have an affinity for order: repeating crystal structures, Euclidean space, continuous functions… Even concepts such as defects are discussed in the context of distracting from order. Things are most logical and best described in straightforward, taxonomical fashion. But what happens when the very application desired is dependent...
College Algebra is a prerequisite for calculus and is thus an important stepping stone in the careers of STEM-intending undergraduates. However, College Algebra has low pass rates across the United States, interrupting students’ pathways to success. To address this concern, a research-oriented university in the Northwest United States restructured its...
In eastern boundary current upwelling ecosystems, mesoscale circulation features such as eddies and upwelling filaments play a prominent role in the transfer of water and the associated plankton from the productive nearshore to the oligotrophic deep sea. The relationship between mesoscale circulation, zooplankton distributions, and the across-shelf transport of coastal...
Collaborative fisheries research provides a mechanism for integrating the unique knowledge, experience, and skills of fishermen and scientists. It is a joint intellectual endeavor that begins with the inception of a project and continues until its final stages, with each group having mutual investment in-and ownership of-the project. Collaborative fisheries...
Each year the United States: Forest Service (USFS) spends billions of dollars fighting forest fires. One strategy used by the USFS to prevent catastrophic fires is through forest restoration programs, in which potential forest fuel is removed through mechanized thinning. This program is expensive and generates high volumes of small-diameter...
Winegrapes are an important crop for Oregon agriculture, ranking amongst the top ten agricultural commodities based on farmgate value. The most widely planted winegrape cultivar in the state is ‘Pinot noir’ (Vitis vinifera L.), and the majority of acreage is produced in the Willamette Valley. Production of quality ‘Pinot noir’...
The omnivorous ground beetle, Pterostichus melanarius Illager (Coleoptera: Carabidae), is a ubiquitous inhabitant of western Oregon crop land. Because it is often the most abundant ground beetle, and attains densities that could lead to serious impacts on its prey sources, I sought to understand the overall diet composition, and specifically...
Dramatic declines in many species of demersal fishes off the West Coast have resulted in the designation of nine commercially important species as being overfished. While the causes of those declines are not clearly understood, the fact remains that a paucity of life history and abundance data exists for many...
A molecular approach to metal oxides allows to the study to fundamental bonding and formation behavior for such metals. Moreover, the molecular nature of such oxides or metal-oxo clusters allows the possibility of exploitation of the properties of the parent oxides. The tetravalent metals, in specific, (M=Zr, Hf, Ce, Th,...
Increased temperatures due to anthropogenic-induced climate change may raise the threat of extinction for taxa with sessile life histories (e.g., plants) in the near future. Linking climate change models to demographic models may provide useful insights into the potential effects of environmental changes on rare plants, and therefore aid in...
There could be a geospatial and socio-ecological intersection between climate change, energy production, and sustainable fisheries management in the United States. Marine renewable energy generation efforts are currently being planned, studied, and initially implemented in the country as a response to climate change. The Bureau of Ocean Energy Management is...
A sawmill is similar to other manufacturing enterprises when it comes to making decisions, scheduling production and meeting customer demands. In order to help sawmills achieve their goals, and because there is such a high degree of variability in the raw material used in this industry, computer simulation has proven...
In this report, two studies are presented that utilize computations to predict and elucidate the reaction mechanisms of two different copper catalyzed reactions. Each study provides insight into the various chemical transformations, as well as the how and why behind regioselectivity and isotopic selectivity. The importance of this research is...
Global biodiversity decline is primarily driven by habitat loss. Deforestation, the primary driver of terrestrial habitat loss, is increasing worldwide, with the most significant impact in the world biodiversity hotspots. Sadly, specific knowledge of such impacts in biodiversity-rich but data-poor countries are still unknown, and many national and regional narratives...
Quantitative assessments of many West coast rockfish stocks of both major and
minor importance to commercial fisheries have shown varying declines in abundances. The population sizes of less-abundant, co-occurring unassessed species may also be
declining. However, determining stock status of the many non-targeted, minor species with high levels of certainty...
The introduction of non-native species can negatively impact native species through reduced genetic fitness resulting from hybridization. The lack of spatiotemporal data of hybrids occurrences makes assessing hybridization risk difficult. Here, I developed a spatially-explicit GIS Hybridization Risk Model (HRM) between native ESA-listed Bull Trout and introduced Brook Trout by...
Mycoplasma haemolamae is associated with mild to marked anemia in stressed, immune-suppressed, and debilitated animals, and may be found in low numbers in healthy animals. The continued presence of the organism, detectable by polymerase chain reaction (PCR)-based assay, may be associated with an underlying problem, such as stress or immune-suppression...
Children with developmental disabilities (DD), particularly autism spectrum disorder (ASD), may use complementary health approaches (CHA), including some modalities that can be unsafe, inefficacious, and/or costly. Still, the prevalence of CHA use among US children with DD is not known and their reasons for use are not well understood. By...
Helical anchors are a type of deep foundation element that can be installed quickly in almost any location and can accept the immediate application of operational loads. The use of helical anchors has expanded in recent decades from its established application in the power transmission industry to more traditional civil...
The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
In recent years, unoccupied aircraft systems (UAS) have become increasingly affordable and straightforward to incorporate in monitoring applications of forested ecosystems. This shift has facilitated interest in using these tools to monitor aspects of forest ecosystems including vegetation health, forest structure and composition, and potential habitat provided by these systems....
Water is an absolute necessity for life as we know it. It provides a useful medium in which chemical reactions take place that allowed for the development of single cellular organisms. When combined with the evolutionary accident that was pho- tosynthesis, water became not only a useful medium chemical reactions,...
Ungulate behavior has been studied extensively but direct observation of free-ranging animals over long periods of time and large geographic areas is often prohibitively difficult. Improved technology, such as GPS collars fitted with motion-sensitive activity monitors, provides researchers with a potential tool to remotely collect fine scale activity and location...
The order Cornales (dogwoods) is the earliest diverging lineage within the most diverse group of flowering plants, the asterids (>80,000 species). Although molecular phylogenetics have significantly improved our understanding of cornalean systematics, early phylogenetic relationships remain uncertain due to an initial rapid radiation. The fossil record of Cornales is extensive...
In this dissertation, I examine emerging economic issues which intersect outdoor recreation, environmental quality, public land use, and public health advisories. First, I explore the potential impacts of social media on visitation to public land. Social media, and in particular Instagram, has been suggested by journalist and land managers as...
The South Pole ice core (SPC14), drilled in the field seasons of 2014/2015 and 2015/2016, is an intermediate length, 1,751-m ice core which preserves a 54,000-year record of past climate and atmospheric composition. The SPC14 ice core adds to the spatial grid of ice cores in Antarctica extending into the...
Ecohydrological connectivity is a system level property that results from the linkages in the networks of water transport through ecosystems, by which feedbacks and other emergent system behaviours may be generated. We created a system dynamics model that represents primary ecohydrological networks to examine how connectivity between ecosystem components impacts...
Generalization is a fundamental mathematical practice across all disciplines and content areas (Amit & Klass, 2005; Lannin, 2005; Pierce, 1902; Vygotsky, 1986; Ellis, Lockwood, Tillema & Moore, 2017). While a considerable amount of research has been conducted on students' generalizing activity in algebraic contexts (Amit & Klass 2005; Becker &...
Conservation of natural resources has become a new watchword of the scientific community. While many terrestrial ecosystems are well protected, marine ecosystems have only recently come to the forefront. Marine Protected Areas (MPAs) have been introduced as a means of protecting biodiversity, commercial stocks, and ecosystem services. There are many...
In 2016, the state of Oregon passed landmark legislation that doubles the state’s Renewable Portfolio Standard and eliminates the use of coal-fired electricity for the state’s two major electric utilities by 2030. The legislation was the first of its kind in the country to outright ban the use of a...
The ability to extract uncertainties from predictions is crucial for the adoption of deep learning systems to safety-critical applications. Uncertainty estimates can be used as a failure signal, which is necessary for automating complex tasks where safety is a concern. Furthermore, current deep learning systems do not provide uncertainty estimates,...
Oregon's estuaries are important ecosystems for scientific study. Consequently, knowledge of what research has been conducted helps us identify benchmarks and plan new projects. A comprehensive bibliography of published research, technical reports, local documents, and data sets is one means of recording this knowledge. For these reasons, the Guin Library...
Simulations of past climates require altered
boundary conditions to account for known shifts in the Earth
system. For the Last Glacial Maximum (LGM) and subsequent
deglaciation, the existence of large Northern Hemisphere
ice sheets caused profound changes in surface topography
and albedo. While ice-sheet extent is fairly well
known, numerous...
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) strength (Yu et al., 1996;
Adkins et al., 2002; Wunsch, 2003; Curry and Oppo, 2005;
Lynch-Steiglitz et al
Formation of cirrus clouds depends on the availability of ice nuclei to begin condensation of atmospheric water vapor. Although it is known that only a small fraction of atmospheric aerosols are efficient ice nuclei, the critical ingredients that make those aerosols so effective have not been established. We have determined...
Full Text:
, Corinna Hoose, Eric J. Jensen, Minghui Diao, Mark A.
Zondlo, Jessica B. Smith, Cynthia H. Twohy, Daniel
Formation of cirrus clouds depends on the availability of ice nuclei to begin condensation of atmospheric water vapor. Although it is known that only a small fraction of atmospheric aerosols are efficient ice nuclei, the critical ingredients that make those aerosols so effective have not been established. We have determined...
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Early Solar System II, D. S. Lauretta,
H. Y. McSween Jr., Eds. (Univ. of Arizona Press, Tucson,
AZ, 2006
The West Coast salmon fishery presents several complexities that have received little attention in the fisheries economics literature. Two of those complexities are reviewed and analyzed in this dissertation. The first, salmon fishermen participate in alternative fisheries within a season demonstrating a complex switching behavior between different species. Second, the...
This study is an ethnographic investigation of residential turnover, organizational memory, and the persistence of Lost Valley, an Oregon ecovillage founded in 1989. Literature on organizational turnover, memory, and persistence is reviewed and integrated with scholarship on intentional communities and ecovillages, generating a theoretical framework for data collection and analysis....
Turbines at wind projects pose a threat to birds and bats flying at altitudes within the rotor swept area. These animals die from colliding with the turbine blades. Estimating mortality, or the total number of bird or bat fatalities at a wind project, is critical to understanding environmental impacts of...
DNA has a well-defined structural transition-the denaturation of its double-stranded form into two single strands-that strongly affects its thermal transport properties. We show that, according to a widely implemented model for DNA denaturation, one can engineer DNA 'heattronic' devices that have a rapidly increasing thermal conductance over a narrow temperature...
Recent research conducted throughout the Northern California Current (NCC) on the ecology of Pacific salmon (Oncorhynchus spp.) indicates that variable ocean conditions affect the community composition of zooplankton in the nearshore environment which, in turn, can affect the quality of prey for fish, sea birds and mammals. Interannual variability in...
Colony size, nesting ecology and diet of Caspian Terns (Hydroprogne caspia) were investigated in the San Francisco Bay area (SFBA) during 2003-2009 to assess the potential for conservation of the tern breeding population and possible negative effects of predation on survival of juvenile salmonids (Oncorhynchus spp.). Numbers of breeding Caspian...
Tree species directly and indirectly affect soil nutrient cycles. I sought to characterize soils and foliage associated with four common canopy tree species (Douglas-fir, western hemlock, western redcedar, and bigleaf maple) in mixed-species old-growth forests of the Oregon Coast Range and to determine whether and how soils differ among the...
In this thesis, I conduct an analysis of blogs in order to understand their potential use in the composition classroom with the goals of students writing for a public audience and developing their rhetorical and civic agency. I do so by exploring the potential for the blogosphere as a public...
A global-scale three dimensional atmospheric transport and chemistry model was applied to simulate transpacific transport of Benzo[a]pyrene (BaP) emitted from Asia. The model results were compared with observations at six monitoring sites. The annual mean and seasonal variation of transport patterns and the contributions of different Asian source regions to...
This study employs interdisciplinary methods to make transnational feminist sense of the microfinance phenomenon. Drawing upon a combination of discourse approach, textual analysis, political economics and critical theory construction, I fused a feminist critical discourse approach to excavate microfinance from neoliberalism. I designed an economic justice framework and executed an...
The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
In the 21st century, environmental deterioration is now an indisputable fact. Reliable and economically viable electricity systems based on renewable sources are urgently needed to replace the environmentally detrimental fossil fuels. The feasibility of incorporating renewable-but-intermittent solar and wind energy heavily depends on the development of cost-effective and safe technologies,...