Legumes are defined as the immature, germinated, or mature edible seeds of legume plants (Fabaceae). The primarily consumed legumes are dry beans, dry peas, lentils, chickpeas, cowpeas, fava beans, and pigeon peas, which are grouped as mature legumes, green beans and peas, which are considered green legumes, and sprouted or...
To evaluate the immunologic and metabolic effects of OmniGen-AF® (Phibro Animal Health corporation, Quincy, IL; OG) supplementation in growing beef cattle, we designed three studies using replacement beef heifers (8.5 and 10.5 months of age) and steers supplemented across backgrounding, transition, and finishing periods. In Study 1, the effect of...
Participation in school garden programs improves health outcomes in K-12
student and is an effective tool for experiential learning. Although most schools in the Corvallis School District have a school garden, none are currently integrated into the curriculum. Using a cross-sectional,online survey, I learned that the majority of parents of...
There is growing public concern about the high proportion of saturated fatty acids in milk fat; however, feed intake, energy partitioning toward milk synthesis, and milk fat concentrations can decrease when cows are fed high concentrations of unsaturated lipids. The objective of this study was to identify the optimal rate...
Blackberry pomace (BBP), a byproduct from juice processing, is often disposed of in landfills. We propose BBP as an antioxidant-rich feed supplement for transition dairy cows. To explore the effects of BBP on antioxidant status, 24 multiparous dairy cows (5 Holstein and 19 Jersey) were assigned randomly to one of...
Milk fever (MF), retained placenta (RP), and left displaced abomasum (LDA) are three common and costly metabolic diseases in cows during the first days of lactation. Some studies suggest that circulating concentrations of α-tocopherol (ATOC) are decreased by these three diseases. It is, however, unknown if and how long lower...
Yeast culture supplementation has been used to improve the health and performance of dairy cows for the last 25 years. To evaluate the effect of a Saccharomyces cerevisiae fermentation product (Diamond V Original XP™) on the health and production of peripartal Holstein cows, two research studies were conducted.
The first...
The transition period is a time of increased nutritional demands and risk to metabolic and infectious diseases in dairy cows due to a suppressed immune system. These problems lead to reproductive challenges, increased culling rates, and decreased milk production postpartum, which leads to decreased profits. Feeding yeast (Saccharomyces cerevisiae) or...
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GerdBobe
The transition period is a time of increased nutritional demands and risk to
Feeding cows flaxseed rich in polyunsaturated fatty acids has been shown to decrease the proportion of saturated fatty acids and increase the proportion of n-3 polyunsaturated fatty acids (PUFAs) in milk. Consuming products enriched in n-3 PUFAs have beneficial effects to human health; thus, feeding cows flaxseed could potentially increase...
As the world population continues to grow we must look for smarter and more sustainable ways to feed everyone. Milk is the first food humans consume and is a good source of protein, fat, and carbohydrates. The following studies sought to determine the effect of feeding blackberry pomace as a...
The dairy industry has indicated that milk hauling sporadically compromises milk quality, but often the reason is unknown. Milk hauling practices are an underexplored area of research, and are in need of attention because during hauling milk is most exposed to the external environment in comparison with any other step...
Lactose intolerance is a common food intolerance that occurs because of a post-weaning deficiency of lactase, an enzyme that cleaves the glyosidic bond of lactose. About 75% of the world's population is lactose intolerant. Common symptoms of lactose intolerance are abdominal pain, bloating and diarrhea. ~25% of the world’s population...
Lung cancer is one of the leading causes of death in the United States. While 90% of lung cancer is due to tobacco smoking, the next major risk factor is pre-existing disease. Cardiovascular disease is reported in 23% of patients diagnosed with lung cancer. A systematic review was conducted to...
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GerdBobe, Committee Member, representing Department of Animal and Rangeland Sciences
Flax seed is a rich source of alpha-linolenic acid (ALA). Feeding broiler birds flax seed can increase n-3 fatty acids (FA) in meat tissues and can increase human intake of n-3 FA. However, non-starch polysaccharides (NSP) in flax seed decrease digestibility of lipids and proteins and have a negative impact...
Abstract
Haptoglobin is an acute phase protein that is elevated in response to tissue damage and infections in dairy cows. The objectives of this study were to evaluate whether serum haptoglobin concentrations in the first week after calving can indicate disease status and severity, and whether haptoglobin concentrations are elevated...
Oxylipins are a class of bioactive lipid metabolites derived from polyunsaturated fatty acids (PUFAs) via enzymatic and non-enzymatic pathways. In order to elucidate their overall biological effects, the knowledge of the entire oxylipin profile is needed as oxylipins can have similar or opposing effects in regard to inflammatory events. Their...
Meniscal tears are a common cause of stifle lameness in dogs. Use of autologous
synoviocytes from the affected stifle is an attractive cell source for tissue engineering
replacement fibrocartilage. However, the diseased state of these cells may impede
in vitro fibrocartilage formation. Synoviocytes from 12 osteoarthritic (“oaTSB”) and
6 normal...
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drafts of the paper.
• GerdBobe analyzed the data, reviewed drafts of the paper.
• Katja F
Reference genes are essential for studying mRNA expression with quantitative PCR (qPCR). We investigated 11 potential neutrophil reference genes (RPL19, GAPDH, ACTB, B2M, HPRT, G6PD, TFRC, PGK1, YWHAZ, SDHA and GYPC) for sheep under disease conditions of foot rot (FR) and with or without Se supplementation. Initial screening was based...
Meniscal tears are a common cause of stifle lameness in dogs. Use of autologous
synoviocytes from the affected stifle is an attractive cell source for tissue engineering
replacement fibrocartilage. However, the diseased state of these cells may impede
in vitro fibrocartilage formation. Synoviocytes from 12 osteoarthritic (“oaTSB”) and
6 normal...
Meniscal tears are a common cause of stifle lameness in dogs. Use of autologous
synoviocytes from the affected stifle is an attractive cell source for tissue engineering
replacement fibrocartilage. However, the diseased state of these cells may impede
in vitro fibrocartilage formation. Synoviocytes from 12 osteoarthritic (“oaTSB”) and
6 normal...
Immunosuppression during the periparturient period leads to increased susceptibility to infectious diseases in beef cows. Newborn calves rely on passive transfer of antibodies from their mothers at birth for protection against diseases in the first two months of age. It is unknown if supranutritional Se supplementation of cows during pregnancy...
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GerdBobe, Committee Member, representing Department of Animal and Rangeland
Sciences
Background: The immune response to microbial infections is compromised in beef cattle at parturition. Innate and adaptive immunoglobulin M (IgM) serve as initial antibodies during microbial infection before the generation of adaptive immunoglobulin G (IgG). Selenium (Se) is an essential micronutrient required by all mammals, which can improve immune responses...
The objectives of the current study were to 1) investigate the effect a high-docosahexaenoic acid (C22:6 n-3, DHA) microalgae product (MAL), and choline dosage in diets containing MAL, on egg production performance, physical egg quality, and nutritional parameters, and 2) determine whether choline dosage influences hepatic lipid metabolism of...
Whey protein is a functional food comprised of numerous bioactive peptides and proteins, including glycomacropeptide (GMP), a hydrophilic casein peptide that separates with the whey fraction during cheesemaking. GMP has a unique amino acid composition, making it a viable nutritional therapy in disorders where certain amino acids are implicated, while...
A previous study conducted in our laboratory demonstrated the critical role that retronasal odors play in vegetable liking and disliking. It remains unclear, however, why some individuals like certain vegetable odors, while others do not. A possible explanation is that some individuals have learned to like the odor of a...
This study investigated the effects of diversification strategy through the inclusion of forb and legume based pastures in the feedbase of dairy cows on annual forage production, botanical composition, spring milk yield, N partitioning and methane emissions from dairy cows in Western Oregon. Using a randomized complete block design, 3...
Flaxseed is a rich source of alpha-linolenic acid (ALA). Feeding laying hens flax seed can increase n-3 fatty acids content (FA) in eggs, thus increasing human intake of n-3 FA. However, non-starch polysaccharides (NSP), which decreases digestibility of dietary lipids and proteins. Addition of carbohydrase enzymes to flax-based layer diets...
OmniGen-AF® (OG; Prince Agri Products, Inc., Quincy, IL) is a feed additive containing brewers dehydrated yeast and B-vitamins that supports immune function in ruminant livestock. Targeted profiling of immune-associated genes in whole blood is an effective platform for identification of a) novel molecular pathways and b) immune response markers to...
This study investigated the impact of organic chromium (Cr) supplementation and flaxseed on live performance, carcass yield, serum metabolites, muscle lipid profile, histopathological aspects, and meat quality parameters. Ninety (n=90), day-old Cobb chicks were fed a corn-soybean meal-based diet containing 0% flaxseed (Control), 10% flaxseed (Diet 1) and Diet 1...
The performance of transit networks must be measured on a regular basis to understand how well these complex systems fulfill their intended purpose and to identify potential opportunities for improvement. Measuring transit network performance is only achievable by defining a specific set of transit network performance indicators (TNPIs). Different schemes...
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess neutral lipids within the parenchymal cells of the liver. The primary etiology is diet-induced and most often exists as a comorbidity with obesity, metabolic syndrome, and/or Type 2 Diabetes. The development of excess liver lipid can be self-limiting...
Cold soaking is a technique used during red winemaking to alter the aroma, flavor, and phenolic content of a wine. However, cold soaking does not come without risk, as this process can result in the production of spoilage compounds such as acetic acid and ethyl acetate if excessive growth of...
Wood density is controlled to a large extent by the relative widths of earlywood and latewood in the stem, but the mechanisms controlling these amounts are poorly understood in coastal Douglas-fir. To understand the role of climatic factors, one hundred and thirty-six increment cores were collected and measured from the...
Hauling is a critical part of the commercial milk supply chain, yet very few studies have aimed to understand its impact on raw milk quality. Consolidation of the American milk industry has led to the use of tanker trucks for up to 24 h between cleanings, which is the maximum...
The serotonergic system plays a significant regulatory role in osteoblast differentiation and proliferation. Serotonin (five-hydroxytryptamine or 5HT) may promote or inhibit osteoblast proliferation depending upon the serotonin receptor isoforms expressed by the cell. Classically, 5HT receptor 1B (5HTR1B) reduces osteoblast proliferation by inhibiting phosphorylation of the cAMP response element binding...
The differentiation of precursor cells into mature adipocytes (adipogenesis) has been an area of increased focus, spurred by a rise in obesity rates. Though our understanding of adipogenesis and its regulation at the cellular level is growing, many questions remain, especially regarding the regulation of the metabolome. The 3T3-L1 cell...
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Jay S. Kirkwood1,2, Cristobal L. Miranda1,2, Gerd Bobe1,3, Claudia S. Maier1,4, Jan
F. Stevens1,2*
1
The differentiation of precursor cells into mature adipocytes (adipogenesis) has been an area of increased focus, spurred by a rise in obesity rates. Though our understanding of adipogenesis and its regulation at the cellular level is growing, many questions remain, especially regarding the regulation of the metabolome. The 3T3-L1 cell...
The differentiation of precursor cells into mature adipocytes (adipogenesis) has been an area of increased focus, spurred by a rise in obesity rates. Though our understanding of adipogenesis and its regulation at the cellular level is growing, many questions remain, especially regarding the regulation of the metabolome. The 3T3-L1 cell...
Feeding conjugated linoleic acids (CLA) improves reproductive performance in dairy cows; however, the molecular mechanisms by which CLA improves reproduction are not well understood. Therefore, we evaluated whether the CLA isomers, trans-10, cis-12 CLA and cis-9, trans-11 CLA altered synthesis of steroidogenic hormones in bovine luteal cells by measuring concentrations...
Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a long-standing reputation to improve health. Xanthohumol’s cytotoxicity to a wide variety of cancer cell lines is well-established. Herein we provide further insight into the cytotoxicity of not only xanthohumol, but also its non-estrogenic derivatives, to a number of colonic...
State-of-the-art, high-resolution mass spectrometry techniques for acquisition of metabolomic and lipidomic data coupled with advanced computational methods provide new opportunities for interpreting large and complex datasets and comprehending the underlying biological processes of diseases. Both metabolomics and lipidomics strive to obtain comprehensive analyses of small molecules, i.e., metabolites and lipids,...
Interferon tau (IFN-τ) is the pregnancy recognition signal secreted by the trophectodermal cells of the developing bovine embryo that prevents luteolysis and maintains critical progesterone production. Recent evidence has suggested in addition to the mechanism of action identified in the uterus, there may be a direct effect of IFN-τ on...
Increasingly congested surface transportation network in urban areas and grow-ing land values make underground transportation systems more attractive for high-ways (i.e., tunnels) and metro system compared to other options [1]. An underground transportation system can preserve the land above for recreational parks, commer-cial buildings, residential homes, or other purposes while...
Three experiments evaluated the effects of different management strategies on immune function and performance of feeder cattle. The objective of experiment 1 was to compare the effects of anticipating, delaying, or vaccinating against Bovine Respiratory Disease (BRD) at the time of weaning and feedlot entry on growth, DMI, and plasma...
During the 21 day incubation period, the fertile egg provides nutrients such as fatty acids for energy and polyunsaturated fatty acids (PUFA) for membrane synthesis to the developing chick. The hypothesis tested in the present study is that the type of PUFA fed to the breeder hen can alter tissue...
Mastitis is a major endemic disease in dairy cows resulting in significant economic losses for the dairy industry. The peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that is able to bind and be activated by natural (e.g., fatty acids) and synthetic (e.g. thiazolidinedione) compounds. PPARγ plays important roles...
The development of technologies such as Building Information Modeling (BIM), light detection and ranging (lidar), and sensor-based systems poses new opportunities for researchers to rethink how construction safety and health can be approached during the design, planning, and construction phases of a project. Nevertheless, the majority of the technology applications...
Graphical models use Markov properties to establish associations among dependent variables. To estimate spatial correlation and other parameters in graphical models, the conditional independences and joint probability distribution of the graph need to be specified. We can rely on Gaussian multivariate models to derive the joint distribution when all the...
Nutrigenomics is a branch of nutrition that seeks to elucidate the relationship between dietary components and expression of genes. Certain bioactive compounds present in the diet have the potential to modulate transcription of genes through their interactions with ligand-dependent nuclear receptors, a series of transcriptional regulators capable of sensing intracellular...
When it comes to carbohydrate, it has been assumed that only mono- and disaccharides, but not oligo- and polysaccharides, can be tasted. However, because of its importance in the human diet, oral detection of starch or its hydrolysis products would be beneficial. The main goal of this study was to...
The budding yeast Brettanomyces bruxellensis has the potential to spoil fermented beverages and cause financial losses, but also contribute positively to certain products such as Lambic beer. It is most notorious for causing “Brett” spoilage of wine, which is characterized by undesirable aromas such as “bandaid” and “barnyard”, therefore most...
The concept of construction industrialization, first raised in the 1960s, refers to the transfer of on-site construction work to an off-site factory to improve quality and reduce cost, time, and safety issues. In some countries, industrialization of construction projects is highly recommended and promoted by governments and local construction institutions...
Endurance riding reflects a relatively new sport among equine athletic disciplines and is growing rapidly. Of all the equine athletic disciplines, endurance riding is the most closely interrelated with veterinary assessment and control to ensure that horses are not exercised beyond their athletic capacity. As endurance riding competition has evolved,...
Face checking in decorative maple veneered plywood panels is a significant
problem for hardwood plywood manufacturers, furniture makers, cabinetmakers, and consumers. Efforts made by panel producers and researchers to minimize checking conducted to-‐date have been limited, and produced contradictory results. In this study the impact of four manufacturing factors believed...
Spinal cord injury (SCI) is a devastating disease which poses health problems in human and veterinary medicine. SCI causes neurological disability, with loss of motor, sensory and autonomic function. This study investigated the efficacy of local treatment with IKVAV-peptide on spinal cord regeneration following compression injury at T12 vertebra in...
Three experiments compared ruminal, physiological, and performance responses of beef steers consuming hay ad libitum and receiving grain-based supplements with (CAM) or without (CO) inclusion of camelina meal. In Exp. 1, 9 steers fitted with ruminal cannulas received CAM (2.04 kg of DM/d) or CO (2.20 kg of DM/d). Steers...
Lignans and proanthocyanidins are plant polyphenols that have shown protective properties against colorectal neoplasms in some human studies. Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to prospectively evaluate the association between lignan and proanthocyanidin intake, estimated from databases linked to a food frequency questionnaire,...
Diet History Questionnaires (DHQ) can only provide general information about a person’s nutritional intake. It is unable to cluster groups of people based on diets or lifestyles, nor identify specific foods that may play a role in disease prevention. The aim of this study was to validate the use of...
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Uesegui, Rachel Hahn, and GerdBobe for aiding in proper lab techniques and my project. Multicultural
Linden (Tilia spp.), a profusely flowering temperate tree that provides bees with vital pollen and nectar, has been associated with bumble bee (Bombus spp.) mortality in Europe and North America. Bee deaths have been attributed, with inadequate evidence, to toxicity from mannose in nectar or starvation due to low nectar...
Dietary selenium (Se) alters whole-blood Se concentrations in sheep, dependent upon Se source and dosage administered, but little is known about effects on immune function. We used footrot (FR) as a disease model to test the effects of supranutritional Se supplementation on immune function. To determine the effect of Se-source...
BACKGROUND: Little is known about α-tocopherol’s bioavailability
as a constituent of food or its dependence on a subject’s age.
OBJECTIVE: To evaluate the α-tocopherol bioavailability from food,
we used collard greens grown in deuterated water (²H collard
greens) as a source of deuterium-labeled (²H) α-tocopherol consumed
by younger and older...
Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4 week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses...
Background: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease and a risk
factor for cirrhosis, hepatocellular carcinoma and liver failure. Previously, we reported that dietary docosahexaenoic
acid (DHA, 22:6,n-3) was more effective than eicosapentaenoic acid (EPA, 20:5,n-3) at reversing western diet (WD)
induced NASH in LDLR-/-...
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Steatohepatitis in LDLR
[superscript -/-] Mice
Depner CM, Traber MG, Bobe G, Kensicki E, Bohren KM, et al. (2013
Diet History Questionnaires (DHQ) can only provide general information about a person’s nutritional intake. It is unable to cluster groups of people based on diets or lifestyles, nor identify specific foods that may play a role in disease prevention. The aim of this study was to validate the use of...
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Crystal V. Carrillo1, Rachel Hahn1,2 , Jaewoo Choi2, Gerd Bobe1,2, and Jan F. Stevens Ph.D.2,3
1College of
Background: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease and a risk
factor for cirrhosis, hepatocellular carcinoma and liver failure. Previously, we reported that dietary docosahexaenoic
acid (DHA, 22:6,n-3) was more effective than eicosapentaenoic acid (EPA, 20:5,n-3) at reversing western diet (WD)
induced NASH in LDLR-/-...
Background: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease and a risk
factor for cirrhosis, hepatocellular carcinoma and liver failure. Previously, we reported that dietary docosahexaenoic
acid (DHA, 22:6,n-3) was more effective than eicosapentaenoic acid (EPA, 20:5,n-3) at reversing western diet (WD)
induced NASH in LDLR-/-...
Diet History Questionnaires (DHQ) can only provide general information about a person’s nutritional intake. It is unable to cluster groups of people based on diets or lifestyles, nor identify specific foods that may play a role in disease prevention. The aim of this study was to validate the use of...
SCOPE: Aim of the study was to identify and monitor metabolite markers of dry bean consumption
in parallel human and mouse studies that each had shown chemopreventive effects of dry
bean consumption on colorectal neoplasia risk.
METHODS and RESULTS: Using LC/mass spectroscopy ± ESI and GC/mass spectroscopy, serum
metabolites of...
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online version of this article atthe publisher’s web-site
Correspondence: Professor GerdBobe, Linus
Selenium (Se) is an essential micronutrient in cattle, and Se-deficiency can affect morbidity and mortality. Calves may have greater Se requirements during periods of stress, such as during the transitional period between weaning and movement to a feedlot. Previously, we showed that feeding Se-fertilized forage increases whole-blood (WB) Se concentrations...
SCOPE: Aim of the study was to identify and monitor metabolite markers of dry bean consumption
in parallel human and mouse studies that each had shown chemopreventive effects of dry
bean consumption on colorectal neoplasia risk.
METHODS and RESULTS: Using LC/mass spectroscopy ± ESI and GC/mass spectroscopy, serum
metabolites of...
SCOPE: Aim of the study was to identify and monitor metabolite markers of dry bean consumption in parallel human and mouse studies that each had shown chemopreventive effects of dry bean consumption on colorectal neoplasia risk. METHODS and RESULTS: Using LC/mass spectroscopy ± ESI and GC/mass spectroscopy, serum metabolites of...
Clinical mastitis (CM), the most prevalent and costly disease in dairy cows, is diagnosed most commonly shortly after calving. Current indicators do not satisfactorily predict CM. This study aimed to develop a robust and comprehensive mass spectrometry-based metabolomic and lipidomic workflow using untargeted ultra-performance liquid chromatography high-resolution mass spectrometry for...
Changes in dietary selenium and selenoprotein status may influence both anti- and pro-cancer pathways, making the outcome of interventions different from one study to another. To characterize such outcomes in a defined setting, we undertook a controlled hepatocarcinogenesis study involving varying levels of dietary selenium and altered selenoprotein status using...
Feeding cows flaxseed rich in polyunsaturated fatty acids has been shown to decrease the proportion of saturated fatty acids and increase the proportion of n-3 polyunsaturated fatty acids (PUFAs) in milk. Consuming products enriched in n-3 PUFAs have beneficial effects to human health; thus, feeding cows flaxseed could potentially increase...
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, & GerdBobe PhD.2
BioResource Research Interdisciplinary Program1
Department of Animal & Rangeland
Abstract
Haptoglobin is an acute phase protein that is elevated in response to tissue damage and infections in dairy cows. The objectives of this study were to evaluate whether serum haptoglobin concentrations in the first week after calving can indicate disease status and severity, and whether haptoglobin concentrations are elevated...
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Include heifers
Diseases to be diagnosed by a veterinarian
Thank you:
Dr. GerdBobe and my
This study was conducted to assess whether healthy adults compared with those with Metabolic Syndrome (MetS) have different mean oxidative-reductive potentials. Static oxidation-reduction potentials and capacity oxidation reduction potentials (sORP and cORP, respectively) were measured in plasma samples. The RedoxSYS® measures sORP in millivolts (mV), which is proportional to the...
We investigated the effect of immunization against gonadotropin releasing hormone (GnRH) using a commercial canine GnRH vaccine on estrus suppression and unwanted estrous behavior in mares. In experiment 1, mares were immunized (n=6) twice with vaccine (5mL) given intramuscularly 4 weeks apart or received a control diluent (n=5). Transrectal ultrasonographic...
Feeding cows flaxseed rich in polyunsaturated fatty acids has been shown to decrease the proportion of saturated fatty acids and increase the proportion of n-3 polyunsaturated fatty acids (PUFAs) in milk. Consuming products enriched in n-3 PUFAs have beneficial effects to human health; thus, feeding cows flaxseed could potentially increase...
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GerdBobe, Animal and
Abstract
Haptoglobin is an acute phase protein that is elevated in response to tissue damage and infections in dairy cows. The objectives of this study were to evaluate whether serum haptoglobin concentrations in the first week after calving can indicate disease status and severity, and whether haptoglobin concentrations are elevated...
Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
Obesity and metabolic syndrome (MetS) affect over 1.9 billion adults and 12.7 million youth in the US. If all of today’s obese American youth become obese adults, the total societal costs over their lifetime may exceed $1.1 trillion. We show that feeding rodents a high-fat diet supplemented with xanthohumol (XN)...
Equine-facilitated mental health (EFMH) is a practice within equine-assisted therapy
(EAT) that has expanded greatly in the last 20 years, but scientific research is still
lacking. Thus far, no attempt has been made to characterize the horses and ponies
currently used in EFMH programs, or to define what characteristics EFMH...
Bovine respiratory disease complex (BRD) is an infection of both the upper and lower respiratory tract and includes components of rhinitis, otitis, tracheitis, and pneumonia. Bovine respiratory disease (BRD) is one of the most common causes of morbidity and mortality of calves in the United States and world-wide. Besides the...
During the past two decades, interest has grown in the role and welfare implications of different head and neck positions (HNPs) in equine biomechanics as well as dressage training and competition. To evaluate the influence of HNP on stride length, 17 horses of varying breeds and dressage levels were studied...
Background:
Canine oral fibrosarcoma (COF) is one of the most common oral tumors in dogs and carries a guarded prognosis due to a lack of effective systemic therapeutic options. Mastinib and imatinib are two commonly used tyrosine kinase inhibitors (TKIs) in veterinary oncology but their potential efficacy against COF is...
During the peripartum period (3 weeks before through 3 weeks after calving, a.k.a. “transition”), high producing dairy cows experience, among others, , oxidative stress and immune suppression that compromise performance and increased incidence of diseases.Among trace minerals, supplementation of Selenium (Se) can help to improve the transition by enhancing glutathione...
Oxidative dysfunction can affect dairy animals during periods of heightened stress, particularly during the transition from pregnancy to lactation and during diseases, such as intramammary infection (IMI), and can contribute to increased inflammation, immune dysfunction, and cell death. As such, methods for ameliorating oxidative stress and restoring redox regulation may...
Vibriosis caused by the bacterial pathogen Vibrio tubiashii is one of several factors contributing to mass larval mortalities of the Pacific oyster (Crassostrea gigas) in Pacific Northwest shellfish hatcheries in recent years. Genetically improved strains of the Pacific oyster resistant to V. tubiashii would be highly desirable. This study investigates...
Two studies evaluated the mineral status of supplemented beef cattle over two different methods of supplementation. The objective of study 1 was to evaluate the mineral status at weaning and subsequent post-weaning performance of calves supplemented prior to weaning, with limited-fed supplements fortified with trace minerals (Cu, Se, and Zn)...
This research investigated gene expression in the canine placenta during the peripartum period. Previous studies have recognized molecular changes that occur in the placenta around the time of placental release in other species, but no study has looked at gene expression in the late gestation canine placenta. Of particular significance...
Metabolomics has recently gained momentum in biomolecule research and complements the genomics and proteomics research space. Metabolomics strives to detect, identify, and quantify all metabolites present in biological samples. In particular, biomolecular analysis using ultra-performance liquid chromatography combined with mass spectrometry (UPLC-MS) has become increasingly important for metabolomic analyses. Similarly,...
The gut microbiome has been previously implemented in a number of diseases. Of note is its substantial role in metabolic syndrome, which encapsulates a group of conditions that increase the risk of cardiovascular disease, type 2 diabetes, and stroke. Understanding the causal relationships between the gut microbiome and host processes...
Local signal detection is useful in many scientific areas such as imaging processing and speech recognition, for extracting meaningful patterns from noisy signals. In this dissertation, we study estimation and local signal detection for spatial data distributed over irregular domains. In particular, we use bivariate splines defined on triangulations to...
Reproductive function in the dog is controlled by feedback mechanisms that involve the hypothalamus, the anterior pituitary gland, and the gonads. Surgical gonad removal, a common procedure performed in dogs for the purposes of sterilization, disrupts the hypothalamic-pituitary-gonadal (HPG) axis and results in permanently elevated concentrations of gonadotropins. Manipulation of...
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder experienced by 10–15% of the global population, manifesting as chronic abdominal pain, bloating and inconsistent bowel habits. The search for effective treatments remains ongoing. One promising contender in this realm is kappa-casein glycomacropeptide (GMP), a milk-derived peptide. Its potential benefits stem...
Bitterness is a common flavor attribute of aged cheese, but excessive levels are a flaw leading to consumer rejection. Bitterness in cheese has been primarily associated with milk casein-derived peptides of medium size (500–3,000 Da) and relative hydrophobicity. Herein, we demonstrate a novel approach for the identification of bitter peptides...
The clean label movement is a persistent, consumer-driven trend that has shifted consumer preferences in favor of foods considered to be more natural. Although lacking legal definitions in food labeling, the terms “natural” and “clean label” are generally used to characterize foods that have short, minimal ingredient lists containing simple...
Non-alcoholic fatty liver disease (NAFLD) is defined as excess hepatic lipid accumulation, in the absence of excess alcohol consumption and chronic liver disease. NAFLD can range in severity from simple fatty liver (steatosis) to non-alcoholic steatohepatitis (NASH). NASH is defined as hepatic steatosis with inflammation and hepatic injury and describes...