Background/Objectives: Advanced glycation end products (AGEs) are implicated in the pathogenesis of atherosclerosis, diabetes and kidney disease. The objective was to describe dietary intake, the dominant source of exposure to AGEs, with carboxymethyl-lysine (CML), a major AGE, in serum and urine, respectively.
Subjects/Methods: Serum and urinary CML were measured in...
Pre-spawning mortality (PSM) presents a major problem for population recovery of spring Chinook salmon (Oncorhynchus tshawytscha) in the Willamette River basin. In certain reaches and years, PSM has exceeded 90%. Histology has been used as the primary diagnostic method to investigate PSM in the Chinook Salmon, and a collection of...
The purpose of this study was to determine if a 5-month
progressive-resistance exercise program would affect measures
of activities of daily living (ADLs) and functional stability
in elderly women. All subjects were ambulatory women, 80 to
93 years old, who lived in assisted-care facilities. Eight
exercise and 7 control subjects...
The purpose of this study was to determine if feeding dogs medium-chain triglycerides (MCT), fish oil, and L-carnitine enriched foods offsets age-associated changes in serum fatty acids (FA) and carnitine metabolites. Forty-one healthy Beagles, mean age 9.9 years (range 3.1 to 14.8), were fed control or one of two treatment...
Low physical activity levels and high serum C-reactive protein (CRP) levels are risk factors for coronary artery disease (CAD) in both men and women. However, postmenopausal women who take hormone replacement therapy (HRT) may have increased risk of CAD because of HRT-related increases in serum CRP. There are two manuscripts...
Health officials have recently been sounding the alarm that depression will soon
surpass many of the major medical conditions in causing disability among adults. Recent
demographic and health trends are generating public health concern about depression.
First, the prevalence of chronic conditions has dramatically increased over the last several
generations....
Case control studies of nonagenarians and centenarians provide evidence that long‐lived individuals do not
differ in the rate of disease associated variants compared to population controls. These results suggest that an enrichment
of novel protective variants, rather than a lack of disease associated variants, determine the genetic predisposition to
exceptionally...
Full Text:
, Andersen SL, Daw EW,
Terracciano A, FerrucciL and Perls TT. Genome‐wide association
study of
Purpose: We examined the prevalence and correlates of unmet assistance need with respect to activities of daily living (ADLs) and instrumental activities of daily living (IADLs) among older American Indians.
Design and Methods: Data for our analyses were collected in 2006–2008 as part of the Native Elder Care Study, a...
This study explores how a platform enables social media influencers to promulgate a consumption ideology. We show how gun influencers, or “gunfluencers,” use Instagram to link products, activities, and meanings to Second Amendment ideology—a gun-centric belief system in the United States colloquially known as “2A ideology.” Through a qualitative study...
The pursuit of personal goals has been linked to general psychological well-being, however, less is known about the association with depression in later adulthood when individuals are contending with age-related changes in health and social relationships. We explored the connection between both health and social relation goals (as measured by...
The relationship between the public and new technologies has historically been a tumultuous one, with public perceptions ranging from excited rapid adoption to standoffish pessimism. In 2011, IBM tried to use competition as a means of showcasing a new technology to the public. This thesis is a work of rhetorical...
As life expectancy continues to rise, adults over 65 are one of the fastest-growing age groups in the United States. As we have made significant strides in mitigating disease, we now have to consider health states that lead to disablement and the inability to age-in-place, including falls, frailty, functional mobility,...
BACKGROUND: The association of vitamin D with heart attack and stroke remains unclear.
METHOD: Using data from the Osteoporotic Fractures in Men Study (MrOS), we collected
dietary vitamin D data from 5,995 participants and serum (25)OH vitamin D from 1,606
participants. The association of vitamin D with prevalent heart attack...
INTRODUCTION: Between 2004 and 2010, the number of home births in the United States rose by 41%, increasing the need for accurate assessment of the safety of planned home birth. This study examines outcomes of planned home births in the United States between 2004 and 2009.
METHODS: We calculated descriptive...
Falls are extremely common among the older adult population, account for substantial morbidity and mortality, and are often potentially preventable. It is estimated that 9 out of 10 of hip fractures in older adults occur as the result of a fall. The economic consequences of hip fractures are estimated at...
INTRODUCTION: In 2004, the Midwives Alliance of North America's (MANA's) Division of Research developed a Web-based data collection system to gather information on the practices and outcomes associated with midwife-led births in the United States. This system, called the MANA Statistics Project (MANA Stats), grew out of a widely acknowledged...
Ample research has demonstrated the largely untapped potential of bioactive peptides (BAPs) for treating systematic chronic inflammation (SCI). Protein hydrolysates are the mixture of peptides resulting from the hydrolytic breakdown of a protein. Numerous hydrolysates contain BAPs and exert beneficial effects in both in vitro and in vivo models. In...
Epidemiological studies on Greenland Inuits in the 1970s and subsequent human studies have established an inverse relationship between the ingestion of omega-3 fatty acids [C₂₀₋₂₂ ω3 polyunsaturated fatty acids (PUFA)], blood levels of C₂₀₋₂₂ ω3 PUFA and mortality associated with cardiovascular disease [CVD]. C₂₀₋₂₂ ω3 PUFA have pleiotropic effects on...
Optimal aging is strongly related to personality factors along with health-behavior habits. Personality has played a key role in understanding the interactions between human behavior and the environment and as a vital predictor in determining health outcomes of individuals. Although previous studies have found links between personality traits and health,...
This study was to develop and evaluate a shirt pattern for a wheelchair tennis player to improve comfort using reducing garment strain using a CAD program. For that, seven body movements related to garment strain during play were analyzed. In order to develop a pattern, a morphological matrix was used...
Sports, being one of the most popular forms of social play for children (Felfe et al., 2016), can contribute to a child’s development, as they are associated with “physical growth, biological maturation, behavioral development, psychological, and social well-being” (Bailey et al., 2015). The purpose of this study was to attempt...
Frailty is a clinical syndrome characterized by decreased resilience to stressors, resulting from dysregulation across multiple physiological systems. Frailty is prevalent in elders and is associated with a wide range of adverse outcomes including death, disability, hip fracture, and falls. In the absence of a gold standard, there is a...
Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
Background: Although some previous research has found ways to find inclusivity bugs (biases in software that introduce inequities among cognitively diverse individuals), little attention has been paid to how to go about fixing such bugs. We hypothesized that Information Architecture (IA)--the way information is organized, structured and labeled--may provide the...
Exposure to ultraviolet (UV) radiation is a primary cause of melanoma and non-melanoma skin cancer and thus represents a critical public health concern. Skin cancer risk behavior research lacks an instrument designed to assess health beliefs about UV exposure that may increase skin cancer risk by increasing risky UV exposure...
Whey protein’s potential for bioactivity is well documented, but there is disagreement on the extent to which it may modulate the immune system towards decreased inflammation. Decreased inflammation is generally perceived as a beneficial bioactivity in foods as excessive chronic inflammation is linked to morbidity and mortality.
This thesis first...
Whey protein isolate (WPI) and glycomacropeptide (GMP) have shown potential immunomodulatory properties. In this study, we investigated their effects on pro-inflammatory cytokine secretion using both in vitro and in vivo models. In LPS-stimulated THP-1-derived macrophages, digested WPI and GMP reduced cytokine expression, while whole GMP increased secretion. The in human...
Cognitive impairment can severely impact quality of life, and can place added strain on family and caregivers.¹⁻³ Moreover, cognitive decline has been shown to proceed to more serious conditions including Alzheimer’s disease and dementia,⁴⁻⁶ making it critical to intervene on risk factors. In addition to traditional risk factors for cognitive...
In the United States, falls are the leading cause of unintentional death with one of every three people 65 years and older falling each year. Falls account for approximately 95% of hip fractures among older adults and falls to the side predominate hip fracture related falls in this population. However,...
It is well established that annotating occurrences
of entities in a collection of unstructured or semi-structured
text documents with their concepts (i.e. entity sets), called
semantic annotation, improves the effectiveness of answers to
users’ queries. However, an enterprise has to spend large amount
of financial, computational, and human resources to...
Objective: To describe associations between self-reported general health status, chronic conditions, and use of supplements containing botanicals (SCB) and describe reasons for use among U.S. adult supplement users.
Design: Cross-sectional analysis using data from the 2009-2014 National Health and Nutrition Examination Survey (NHANES). Information on self-reported dietary supplement use and...
Marine sediments are vast sources and reservoirs of methane, a potent greenhouse gas. Most of this methane is anaerobically oxidized by archaea before it can reach the overlying ocean, though the efficiency of this process often depends on methane fluxes and mechanisms of fluid transport. Anaerobic methanotrophic archaea, or ANME,...
Otoferlin is a C2-domain, transmembrane protein whose mutated form is responsible for the DFNB9 subtype of prelingual hearing impairment. Mutations in otoferlin cause an autosomal recessive, non-syndromic form of deafness that is characterized by auditory neuropathy/ auditory dissynchrony (AN/AD), meaning that the outer hair cells (OHCs) are normal, and the...
This study investigated the impact of organic chromium (Cr) supplementation and flaxseed on live performance, carcass yield, serum metabolites, muscle lipid profile, histopathological aspects, and meat quality parameters. Ninety (n=90), day-old Cobb chicks were fed a corn-soybean meal-based diet containing 0% flaxseed (Control), 10% flaxseed (Diet 1) and Diet 1...
Despite the advances in surgery, physical therapy, and pharmaceutical agents, muscle
dysfunction (i.e., atrophy and weakness) continues to impair recovery from an anterior
cruciate ligament (ACL) injury and surgery. Ischemia-reperfusion injury during surgery
and the subsequent limb disuse are two events experienced by patients having ACL
surgery. Oxidative stress and...
Corneal ulcers are one of the most common eye conditions of the horse, with potentially serious complications such as loss of vision or the eye itself. They are extremely painful due to the large number of sensory nerve endings found in the cornea. Horses frequently show signs of ophthalmic pain...
Falls in older adults are an important concern due to the potential injuries associated with falling. Decreases in muscle strength as a result of natural aging could impair the ability of older adults to prevent either a backward or forward fall. Two musculoskeletal models were used to predict the effect...
Nutrition and health-related risk factors could be identified through the
implementation of the nutrition preventive strategies, such as nutrition screening,
for the Chinese elderly population who are at high risk of malnutrition. Efficacious
culturally sensitive nutrition assessment tools and nutrition screening tools hold the
most essential value to assess the...
Ageism in the context of global population aging could lead to increasing human and economic costs. Age stereotypes tend to be negative (Hummert, 1990) and ubiquitous (Nelson, 2002) there are a variety of well documented detrimental consequences of negative age stereotypes on older adults' physical, cognitive and psychological outcomes (Hummert,...
Over time, Open Source Software (OSS) has become indispensable in the creation and upkeep of software products, serving as the fundamental building block for widely used solutions in our daily lives, including applications that enable communication, entertainment, and productivity. A sustainable OSS ecosystem is one that attracts and retains a...
Environmental scientists, land managers, and policy actors are increasingly presented with high-stakes high-uncertainty problems stemming from human-ecosystem interactions. To help address these problems, scientists frequently use models that produce enormous geospatial and temporal datasets that are constantly modified and often seek input from communities outside their discipline. To assist scientists—as...