The heartwood of western redcedar (Thuja plicuta) is known for its natural resistance to fungal attack, but some users of western redcedar utility poles have suggested that its durability may be diminished as suppliers begin to harvest trees from younger stands. The decay resistance of western redcedar samples from the...
The potential of 17 hydroxylamine derivatives as wood preservatives was assessed on ponderosa pine sapwood blocks exposed to one of two decay fungi: Gloeophyllum trabeum or Trametes versicolor. Weight losses on untreated controls were generally lower with the white-rot fungus (T. versicolor) averaging 30.4 percent, while those for the brown-rot...
Port Orford cedar (Chamaecyparis lawsoniana) has a reputation for being resistant to fungal attack, but much of the work to support this premise used older growth material (80-100 yr old). Given the tendency for the heartwood from the second growth of some species to be less durable, we evaluated the...
Molds are an increasingly important issue for all building materials, including
wood. While washing with bleach is a commonly recommended method for removing
molds, and the associated discolorations, there is surprisingly little information on the
effectiveness of this treatment. The ability of mold removal treatments to brighten
wood and eliminate...
Heartwood durability of Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco var. menziesii) was studied as a function of vertical and radial position in boles of trees with a wide range of leaf area/sapwood area ratios. Six 34- year-old trees were harvested from each of three plots established 14 years before: very dense,...
Wood that is submerged in fresh water for long periods has increased permeability and other changed properties. Wood that is submerged in salt water may absorb considerable quantities of salts, which may render the wood resistant to microbial colonization. In this report, we describe decay tests on Douglas-fir sapwood and...
The ability of natural and synthetic hinokitiol, as well as a water soluble derivative (hinokitiol sodium salt), to protect wood against fungal attack was examined. Synthetic and natural hinokitiol provided similar protection. All three materials exhibited similar antifungal activity against Aspergillus niger and Penicillium citrinum on yellow poplar wafers at...
A solid, crystalline fumigant (dazomet) with and without a supplemental copper compound was evaluated as an internal decay control treatment on Douglas-fir poles in two long-term field tests. Methylisothiocyanate (MITC), the decomposition
product of dazomet, was used as a measure of effectiveness. MITC levels in the wood were above the...
Bacillus subtilis and essential oils have been explored separately for their ability to limit colonization by wood stain and mold fungi, but neither approach has been completely effective. One alternative strategy would be to combine the bacterial biocontrol with one or more natural products extracts. In this report, the ability...
The Polycomb Repressive Complex 2 (PRC2) catalyzes genome transcription repression through the methylation of lysine residue 27 in the amino terminal region of histone 3 (H3K27me1/2/3) [2], [7]. PRC2 is made up of three highly conserved core subunits: Kmt6, Eed, and Suz12. Accurate distribution of PRC2 is essential for proper...
Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...
PRC2 (Polycomb Repressive Complex 2) mediated gene silencing plays an important role in cell differentiation, stem cell plasticity, and tumor suppression. In fungi, it is also involved in pathogenicity. The catalytic subunit, KMT6, trimethylates lysine 27 on histone h3 (H3K27me3) at loci targeted for silencing. In animals, PRC1 and PRC2...
In eukaryotes, the defined loci on each chromosome, the centromeres, accomplish
the critical task of correct cell division. In some organisms, centromeres are
composed of a euchromatic central core region embedded in a stretch of
heterochromatin and the inheritance and maintenance of centromeres are controlled
by dynamic epigenetic phenomena. Although...
Modifications of histone tail amino acid residues are necessary for many reactions involving chromatin. These processes can produce transcriptionally active, euchromatic, or inactive, heterochromatic, segments of DNA. The formation and maintenance of facultative heterochromatin is critical for the proper growth and development of many eukaryotes. Euchromatin can be changed into...
Fungi are capable of growth on a wide variety of carbon sources, both living and dead. They can produce an arsenal of enzymes and transporters for harvesting sugars, polysaccharides, amino acids, lipids and micronutrients from their environments [1]. Within the nucleus of a cell, transcription factors (TF) control whether genes...
Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase that initiates facultative heterochromatin formation by trimethylating histone H3 on lysine 27 (H3K27me3). Mutations within its three primary subunits, KMT6, EED, and SUZ12, result in inherited diseases and sporadic cancers. In the fungus Fusarium graminearum, deletion of the gene encoding the...
Mutation of repetitive DNA by repeat-induced point mutation (RIP) is a process that occurs in many filamentous fungi of the Ascomycota during the sexual cycle. Concurrently, direct DNA repeats are often deleted by homologous recombination at high frequency during the sexual cycle. Thus, the processes of RIP and deletion compete...
DNA is often described as the “blueprint for life”. In eukaryotes this information is contained within linear chromosomes of varying size and number. During cell division, the chromosomes must be faithfully segregated into each daughter cell to avoid disease and sustain life. This process is carried out by the kinetochore...
In recent years, non-coding DNA has received much attention within the scientific
community. This attention has not only illuminated the mystery behind functionally
important regions like the centromere, but has also brought to light additional important
questions regarding centromere mechanisms, inheritance, and cellular recognition by the
kinetochore, a protein complex...
DNA segments in the fungus Fusarium graminearum were identified as possible genes encoding for chromodomain proteins (CDPs), and targeted for genetic manipulation. Targeted single-gene deletion strains, as wells as GFP-S tag fusion strains, were generated from wildtype F. graminearum protoplasts, and verified strains were screened for phenotypic differences, such as...
BACKGROUND/PURPOSE: Exposure from medical radiation sources are on the rise in the United States. Often the highest potential source of radiation dose to patients and radiology staff occur during interventional radiology procedures performed using fluoroscopy and digital subtraction angiography (DSA) to provide image guidance in minimally invasive surgical procedures. Several...
A new approach is described that offers a risk-informed performance-based (RIPB) framework for quantifying the risk associated with a cyber-attack on a nuclear power generating facility.
The first part of the method involves 1) the creation of a simplified 10 CFR 73.54 compliant cyber infrastructure, 2) modeling of design basis...
Prompt radiation accounts for 3% of the energy released in a nuclear blast. Simulating the prompt radiation will help identify the potential changes to the ambient temperature and pressure of air around the blast. The changes in ambient conditions may alter blast wave effects. The relationship between the energy deposition...
Recent advances in robotics have led to interest in exploring soft robotic technologies as an engineering control for reducing the risk of radiation exposure for workers in the nuclear industry. These emerging “soft” technologies offer many advantages over traditional rigid robotic systems and can perform a wide range of tasks...
Eye plaque brachytherapy is an established technique for the treatment of ocular melanoma that allows for the preservation of the affected eye as well as visual function. A common treatment planning system for eye plaque procedures, Plaque Simulator (PS), assists physicists in calculating the radiation dose to the tumor and...
Understanding the origin and nature of intra specific biodiversity enables us to better conserve and manage animal populations. Biological diversity is seen at different scales and for different traits such as behavior, morphology, physiology, and life history. Behavior is especially important since behavioral changes are believed to precede changes in...
Introduction: A bone deficit is found to persist five years following a hip fracture and 10 years post tibial fracture in adults. We examined the effect of whole body vibration (Vib) as a means for enhancing whole body composition and bone recovery following hindlimb unloading (HU) of adult female rats....
In this dissertation, a novel method for analyzing computed transition states (TS) for organic reactions is disclosed. It introduces the use of localization-delocalization matrices as parameters in a linear free energy relationship to determine the transition state interactions responsible for differences in energy between the major and minor TS in...
Manned missions beyond low-Earth orbit present tremendous, multifaceted radiological challenges. The deep space radiation environment contains high-energy protons and heavy ions, which are not sufficiently shielded by the aluminum alloys that have historically been used in spacecraft. To address these shielding concerns, polymer-based nanocomposites have been proposed. Radiation transport simulations...
Temperature influences the incidence of chemically induced cancer in fish,
with warmer temperatures being associated with higher cancer incidence. The
mechanisms of temperature-modulated chemical carcinogenesis in fish, however,
have not been described in detail. Therefore, one primary objective of this study
was increased understanding of how temperature-modulated genotoxicity of 7,12-...
The purpose of this study was to analyze preservice teachers' talk about gender issues in education through a poststructural feminist theoretical framework. Eighteen Master of Arts in Teaching students volunteered to participate in a seminar. During the seminar the participants wrote about and discussed gender issues in teaching. Data collected...
The purpose of this phenomenological study is to describe how Oregon governors
Barbara Roberts and John Kitzhaber, whose tenures both coincided with the passage
and implementation of property tax limitation measures, determined the community
college budgets within their recommended state budgets. The stories of Robert’s 1993
and Kitzhaber’s 2001 decisions...
The ability to treat Scots pine (Pinus sylvestris) and Norway spruce (Picea abies) with oilborne copper-8-quinolinolate or with waterborne chromated copper arsenate, ammoniacal copper zinc arsenate, or ammoniacal copper quaternary was assessed using commercial treatment facilities in the Pacific Northwest. In general, Scots pine was more easily treated than was...
There is a growing need for an expanded Probabilistic Risk Assessment (PRA) framework that is able to accommodate new uncertainties that are present in Generation 3+ reactor designs. Dynamic PRA (DPRA) can allow for a more realistic risk assessment by taking advantage of established nuclear simulation codes to drive Dynamic...
Traditional robots have a long history in nuclear-related work because their integration decreases risk to humans in dangerous environments. Soft robotics is one promising new branch of traditional robotics with proposed applications in industry, medicine, and society. Collaborators from the Robotics mLab at Oregon State University (OSU) are currently working...
Compliance with 10CFR 20.101 requires that exposure to the skin be assessed at a depth of 0.007 cm over 10 cm² area. This depth generally corresponds to the interface between the epidermal and dermal layers of the skin. The Nuclear Regulatory Commission states the criteria for evaluating skin dose from...
Radiation therapy is used in approximately half of all cancer treatments. The rapid advances in radiation therapy have led to techniques that are much more complex and therefore must be more carefully assessed for safety and efficacy. Accurate quality assurance methods must be implemented to provide patient safety and confidence...
Fission product yields (FPYs) are used for a wide range of applications including nuclear fission theory, nuclear reactor design, reactor antineutrino anomaly, stellar nucleosynthesis, and nuclear forensics. These applications rely on FPYs that were last evaluated in 1993, which included measurements from all over the world up until 1993. In...
In the U.S., the Nuclear Regulatory Commission (NRC) is responsible for setting annual dose limits. For cases of hot particle contamination these limits are set at depths in skin of 7 mg/cm², 300 mg/cm², and 1000 mg/cm². However, at such shallow depths, the lack of charged particle equilibrium (CPE) precludes...
Photoneutron contamination produced during high-energy, external beam radiotherapy can contribute to total patient dose. This aspect of unwanted dose is not currently evaluated for patients undergoing radiation therapy. While multiple studies have examined the neutron dose from beams with energies above 10 MeV, research assessing neutron dose from a 10...
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Camille J. Lodwick
Photoneutron contamination produced during high-energy, external beam
Ophthalmic plaque brachytherapy is a form of internal radiation treatment for uveal melanoma, the most common eye cancer in adults. During treatment, a plaque containing radioactive seeds is surgically attached to the sclera, directly adjacent to the ocular tumor site. Plaque Simulator™ is an eye plaque brachytherapy planning software that...
The Ambrosia Lake West Site is a former uranium recovery facility located north of Grants, New Mexico. It currently serves as a uranium mill tailings site undergoing reclamation and decommissioning. High velocity winds are common in the area, causing soil erosion via aeolian processes. Strong winds may carry soil for...
In a radiological emergency scenario, the capability to rapidly visualize radiation emitted from debris, contamination, or absorbed in biological samples, while visualizing the non-radioactive (or “conventional” image) features within a field of view, will provide critical information to support optimization of further analysis, sample collection, and decision making. This research...
The International Commission on Radiological Protection (ICRP) has modeled twelve reference animals and plants (RAPs) with simple geometric shapes to be used when estimating radiation dose to non-human biota (NHB). In recent years, there has been interest in creating more realistic models in order to better understand the radiation interactions...
The International Atomic Energy Agency (IAEA) is responsible for verifying the mass of elemental uranium in various forms (powders, pellets, scrap) as part of safeguards inspections at nuclear fuel fabrication facilities in support of the nuclear non-proliferation treaty. Current methods require in-field dissolution chemistry, which is time consuming and imposes...
Fiber-optic-coupled dosimeters (FOCDs) are a relatively new method in which to obtain in-vivo dose concomitant with radiation treatment. Accurate live dosing can be achieved virtually anywhere due to their small dimensions (0.2 mm) which can be accommodated by a catheter. The purpose of this experiment is to characterize the electron...
The pulsed sphere benchmark problems are a set of physical experiments that have been used to verify Monte Carlo codes and evaluate nuclear data. All Monte Carlo codes rely on benchmark experiments that test the features of the code to verify that the simulations are producing realistic results. In the...
BACKGROUND: The frequency of C-arm fluoroscopy procedures is increasing and it has become prudent to increase the awareness of patient radiation exposure to minimize patient risk. There is a strong potential for variability in patient exposure levels and a need for minimizing unnecessary exposure. The variability in C-arm fluoroscopy can...
Of great importance in the design of a nuclear power plant is the evaluation of shielding from the ionizing radiation produced in the core of the nuclear reactor. This requires simulation software to predict the dose rates in the areas of interest. Comparing the simulation of the same modeled system...
The objective of this research is to design a portable neutron detector that is lightweight and responds to neutrons with energies of 20 MeV and greater. The instrument will be used as a ‘sniffer’ probe for identifying shielding weaknesses at high-energy particle accelerators and be paired with a plastic scintillator...
The Ariel Measuring System (AMS) is a national asset in responding to radiological or nuclear events. The AMS operates out of several aerial platforms, such as the BK-117 helicopter and the P3 Long Range Tracker, under many equipment configurations. Measurements can be telemetered real time to reach back for evaluation...
Chromosome segregation relies on coordinated activity of a large assembly of proteins, the kinetochore interaction network (KIN). How conserved the underlying mechanisms driving the epigenetic phenomenon of centromere and kinetochore assembly and maintenance are remains unclear, even though various eukaryotic models have been studied. More than 50 different proteins, many...
Full Text:
complex subunits and not all of them are essential
(G. Ekberg and M. Freitag unpubl). These differences
Differences in stain susceptibility were evaluated on sterile and unsterile samples of freshly sawn, frozen and thawed, or oven-dried and rewetted ponderosa pine sapwood. Samples treated with sterile medium or with medium inoculated with either Pseudomonas putida or Bacillus subtilis were inoculated with selected wood-staining fungi. In general, fresh unsterile...
Optimal commercial fishery management sustains each salmon species' population while maximizing economic benefits. This thesis addresses two questions. What are the Alaska Department of Fish and Game's and the Board of Fisheries' intentions when conducting a fishery management plan in Upper Cook Inlet? How does it compare to its implementation?...
Treating durable, second-growth or plantation-grown material with supplemental chemicals could improve durability while enhancing the uniformity of the products. To test this hypothesis, the effect of two candidate biocide treatments on the durability of teak, redwood, and western redcedar was assessed in a ground proximity field test established in Hawaii....
Epigenetic mechanisms are important for control of plant development, and may play a particularly important role in trees given their long life cycles and distinctive and stable tissue types. To help understand the role of epigenetics in tree development, we produced transgenic poplars with reduced activity of the DDM1 genes,...
Non-coding ribonucleic acid (ncRNA) is of interest for its diverse roles in cell and viral biology. RNA molecules vary greatly in terms of size, structure, and function. In recent years, the modification of existing RNA structures has been used for biochemical methods of enormous impact including CRISPR and RNAi methods....
Purpose: Model-based dose calculation algorithms (MBDCAs) have become clinically available within the past several years in commercially available brachytherapy planning systems. This work investigates the application of a 510(k) approved MBDCA Acuros™ BV and establishes a reproducible method of validation. The research is broken into three primary research goals. The...
This thesis presents a feasibility study of a thorium fueled thermal spectrum breeder-burner reactor that operates without chemical reprocessing. Materials were evaluated for their potential as moderators using standard analytical methods. These materials were then used as moderators to evaluate criticality and enrichment in an infinite fuel pin lattice. The...
Purpose: Stereotactic radiation therapy and stereotactic radiosurgery deliver radiation precisely to tumors, using special equipment to position and demobilize patients. The VisionRT system, with its component AlignRT, is a non-invasive stereotactic positioning and tracking system that uses cameras to capture infra-red images of patients, and process these images, to obtain...
Cyclic nitramines released into all environmental compartments through anthropogenic activities are toxic and possibly carcinogenic and mutagenic. Soils on military ranges, located throughout the world in various climatic regions and close to human activities, are especially susceptible to cyclic nitramine contamination. The properties of soils on military ranges will directly...
Climate change and other anthropogenic impacts are threatening the existence of millions of species around the globe. On western continental boundaries, the large-scale secondary process of upwelling, which brings low pH, deoxygenated, high nutrient seawater to the surface, is compounded by climate change, that together could drive some species to...
The recent reductions to the international dose limit recommendations for the lens
of the eye have renewed interest in radiation protection strategies in interventional
fluoroscopy, where eye-lens radiation exposure occurs frequently. Radiationshielding
eyewear can significantly reduce lens dose in these scenarios, but accurate
protection factors are elusive because they depend...
Transcription factor (TF) genes were modified endogenously to include epitope tags for identification of TF protein binding sites by Chromatin Immunoprecipitation (ChIP), followed by high throughput sequencing. We used RNA-sequencing in carbon sources of sucrose, butyrate, and oleate in far-1, far-2, and a double far-1; far-2 mutant to find transcripts...
Impact bending and breaking radius were used to measure loss in toughness caused by basidiomycetes isolated from wood. Small test pieces were used to accelerate testing. Wide differences were found among, and sometimes within, the 26 species tested. Brown-rot fungi tended to cause greater losses than white-rot fungi, but no...
A small block test was used in assessing whether pelletized sodium n-methyldithiocarbamate (NaMDC) would decompose and produce methylisothiocyanate (MITC) and thereby eliminate Antrodia carbonica colonies from Douglas-fir heartwood. Also evaluated were the effects of wood moisture content, dosage, incubation period, pH level, and presence of copper sulfate on percentage of...
Mylone@ and tridipam are two solid chemicals that decompose to produce methylisothiocyanate (MIT), a highly effective wood fumigant. In this study, two techniques -- a rapid, test-tube method and small-scale, wood-block assay -- were used to determine the effect of the pH of various chemical buffers on the decomposition of...
As a standard practice, the use of radioactive materials has been widely used when treating many diseases. In recent years advances in biotechnology and labeling techniques have broadened the application of these materials. Candidates selected for radiopharmaceutical therapy may be treated on an outpatient basis or hospitalized following administration to...
Pantoea agglomerans pathovar betae (Pab) is a bacterium that causes galls on the roots of beet plants, resulting in reduced marketability of beet roots and crop loss. Pab uses a type III secretion system (T3SS) to infect and cause galls on beets. The T3SS is a molecular syringe-like structure that...
The Neutron radiography facility (NRF) at Oregon State University (OSU) has been modified to begin working on the non-destructive evaluation of concrete materials to study the early stages of shrinkage, cracking, and water transport of concrete during the curing process.
The objective of this work is to investigate the efficiency...
Thin foil samples of special nuclear materials (SNMs) were irradiated for 60s using a Mark TRIGA II reactor, and their associated gamma emissions were recorded with a count time of 60s following irradiation. A rapid pneumatic transfer system was used to irradiate the samples in front of beam port #4....
Since the International Commission on Radiation Protection (ICRP) recommended a revision to the eye lens dose limits in ICRP Publication 118 (Stewart, 2012) the radiation protection community has conducted many new studies related to eye dosimetry. The recommended reduction of eye lens dose limits may result in the reduction of...
When the ICRP updated their recommended limits for eye dose, they ignited a renewed interest in eye dosimetry. Especially, how the updated eye dose estimates affect current regulations and what that would mean to a radiation worker. Radiation workers are commonly required to wear leaded eyeglasses to reduce their dose...
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David M. Hamby
Abstract:
When the ICRP updated their recommended limits for eye dose, they
Just as the structure of a protein determines its function, protein motions and lack-of-structure are also key to regulating protein behavior. The human eye lens is made up of high concentrations of extremely stable crystallin proteins, but even in this context, small motions over time can cause a loss of...
Microtechnology was used to study the chemical reduction of dissolved carbon dioxide into useful products. A novel TiO₂ photocatalyst was used to activate the reaction under ultraviolet irradiation. CO₂ was dissolved in aqueous and 50% BMIM-BF₄ (ionic liquid) solutions. The introduction of an ionic liquid increased the solubility of CO₂...
Ocean Drilling Program (ODP) Leg 204 to Hydrate Ridge, located on the continental slope offshore Oregon (USA), was the first drilling expedition dedicated to understanding gas hydrate processes in accretionary complexes and provided a testbed for a number of different techniques for estimating the gas hydrate content of sediments. It...
Nanostructured material has been projected to be the next generation material for the detection of ionizing radiation due to the uniquely superior physical processes associated with charge creation and by virtue of their optoelectronic tunablility. Semiconducting Nanocrystal (NC) detectors, by nature of their low band gap material, low fabrication costs,...
Breast cancer is the leading cancer in women with an estimated 13% of women in the United States developing a form of invasive breast cancer in her lifetime. The survival rate is estimated to be 85%, but the American Cancer Society estimates that early detection of breast cancer in the...
Cephalopod-inspired soft robot arms have been studied as a new type of manipulator. These arms have been proposed for reach and grab tasks, underwater locomotion via swimming and walking, and robotic surgery. However, the capabilities of existing soft arms are limited to simple motions and light loads. Arm design has...
One of the pervasive problems arising in our modern, digital world surrounds data breaches where an adversary, through zero-day exploitations, phishing, or old-fashioned social engineering attacks, gains access to a service’s data stores. Our society increasingly relies on these cloud-based services for everything from our taxes to personal communication. As...
The decline in Barents Sea ice has been implicated in forcing the “warm-Arctic cold-Siberian” (WACS) anomaly pattern via enhanced turbulent heat flux (THF). This study investigates interannual variability in winter [December–February (DJF)] Barents Sea THF and its relationship to Barents Sea ice and the large-scale atmospheric flow. ERA-Interim and observational...
Natural products from plants, bacteria, and fungi play an important role in society. Over the last 35 years, natural products and their derivatives have inspired over 60% of all FDA approved small-molecule drugs, and are among the top prescribed therapeutics.1-2 Fleming’s discovery of the fungal antibiotic penicillin started the “Golden...
Antimicrobial peptides (AMPs) play an important role in the innate immune system. Determining the pathways by which these proteins are regulated allows for modulation of their expression for better health. Two families of antimicrobial peptides have been studied in humans: cathelicidins and defensins. There is a single cathelicidin in humans...
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5. Q-PCR for CAMP with increasing doses of 1,25(OH)2 D3 with
10-5 M disulfarim in U937 cells
Commercial methodologies for producing fungal pigments are of worldwide interest due to the desire to move away from synthetic dyes. Chlorociboria species and Scytalidium species have been reported to produce sufficient yields of pigments for commercial production and have attracted special attention because of their use in spalted wood applications....
Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
The spatial and temporal patterning of sequence specific transcription factors (SSTFs) contributes to cell type specification and organ formation during embryogenesis. Homeodomain transcription factors are evolutionally conserved among invertebrate and vertebrate animals. They are responsible for body segmentation and organogenesis. Lbx1 and Pitx2 both are homeodomain transcription factors contributing to...
The cereal pathogen Fusarium graminearum produces secondary metabolites toxic to humans and animals, yet coordinated
transcriptional regulation of gene clusters remains largely a mystery. By chromatin immunoprecipitation and high-throughput
DNA sequencing (ChIP-seq) we found that regions with secondary metabolite clusters are enriched for
trimethylated histone H3 lysine 27 (H3K27me3), a...
Full Text:
Metabolite Gene
Clusters
Connolly LR, Smith KM, FreitagM (2013) The Fusarium graminearum Histone H3
K27
The cereal pathogen Fusarium graminearum produces secondary metabolites toxic to humans and animals, yet coordinated
transcriptional regulation of gene clusters remains largely a mystery. By chromatin immunoprecipitation and high-throughput
DNA sequencing (ChIP-seq) we found that regions with secondary metabolite clusters are enriched for
trimethylated histone H3 lysine 27 (H3K27me3), a...
The cereal pathogen Fusarium graminearum produces secondary metabolites toxic to humans and animals, yet coordinated transcriptional regulation of gene clusters remains largely a mystery. By chromatin immunoprecipitation and high-throughput DNA sequencing (ChIP-seq) we found that regions with secondary metabolite clusters are enriched for trimethylated histone H3 lysine 27 (H3K27me3), a...
As the negative impacts of a fossil fueled electricity market are becoming more prevalent and destructive, the necessity for alternative energy techniques increases as well. However, before commercial implementation is underway, these alternatives must be assessed from three important perspectives: environmentally, economically, and socially, which are known as the three...
Radiation protection has historically been from a human protection approach, therefore many studies have neglected the potential dose contribution from the gastrointestinal tract (GIT) in animal studies. The International Commission on Radiological Protection (ICRP) utilized simplified geometric shapes with Dose Conversion Factors (DCF) based on homogenized models for the trout...
Instead of expensive and destructive chemical analysis, nondestructive assay (NDA) through radiography and tomography can be a faster, easier, and more appropriate method of analyzing spent nuclear fuel (SNF). As a preliminary study for the future design of a submersible SNF imaging system, this thesis demonstrates the ability of NDA...