Dendrimers are well-defined, polymeric nanomaterials currently being investigated for biomedical applications such as medical imaging, gene therapy, and tissue targeted therapy. Initially, higher generation (size) dendrimers were of interest because of their drug carrying capacity. However, increased generation was associated with increased toxicity. The majority of studies exploring dendrimer toxicity...
Inherent nanomaterial characteristics, composition,
surface chemistry, and primary particle size,
are known to impact particle stability, uptake, and
toxicity. Nanocomposites challenge our ability to predict
nanoparticle reactivity in biological systems if they
are composed of materials with contrasting relative
toxicities. We hypothesized that toxicity would be
dominated by the nanoparticle...
Inherent nanomaterial characteristics, composition,
surface chemistry, and primary particle size,
are known to impact particle stability, uptake, and
toxicity. Nanocomposites challenge our ability to predict
nanoparticle reactivity in biological systems if they
are composed of materials with contrasting relative
toxicities. We hypothesized that toxicity would be
dominated by the nanoparticle...
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toxicity of engineered silver
nanoparticles
Josephine A. Bonventre • Joseph B. Pryor •
BryanJ. Harper
Inherent nanomaterial characteristics, composition, surface chemistry, and primary particle size, are known to impact particle stability, uptake, and toxicity. Nanocomposites challenge our ability to predict nanoparticle reactivity in biological systems if they are composed of materials with contrasting relative toxicities. We hypothesized that toxicity would be dominated by the nanoparticle...
Cellulose is an abundant and renewable resource currently being investigated for utility in nanomaterial form for various promising applications ranging from medical and pharmaceutical uses to mechanical reinforcement and biofuels. The utility of nanocellulose and wide implementation ensures increasing exposure to humans and the environment as nanocellulose-based technologies advance. Here,...
The integration of rapid assays, large datasets, informatics, and modeling can overcome current barriers in understanding nanomaterial structure–toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard rankings for nanomaterials. Here, we present the use of a rapid, low-cost assay to perform screening-level toxicity evaluations of nanomaterials in vivo. Calculated...
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) metric of toxicity”.
Authors: BryanHarper, Dennis Thomas, Satish Chikkagoudar, Nathan Baker, Kaizhi
The integration of rapid assays, large datasets, informatics, and modeling can overcome current barriers in understanding nanomaterial structure–toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard rankings for nanomaterials. Here, we present the use of a rapid, low-cost assay to perform screening-level toxicity evaluations of nanomaterials in vivo. Calculated...
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diverse nanomaterials using the embryonic zebrafish (EZ)
metric of toxicity
BryanHarper . Dennis Thomas
Zinc oxide nanoparticles (ZnO NPs) are widely used in a variety of products, thus understanding their health and environmental impacts is necessary to appropriately manage their risks. To keep pace with the rapid increase in products utilizing engineered ZnO NPs, rapid in silico toxicity test methods based on knowledge of...
Zinc oxide nanoparticles (ZnO NPs) are widely used in a variety of products, thus understanding their health and environmental impacts is necessary to appropriately manage their risks. To keep pace with the rapid increase in products utilizing engineered ZnO NPs, rapid in silico toxicity test methods based on knowledge of...
Zinc oxide nanoparticles (ZnO NPs) are widely used in a variety of products, thus understanding their health and environmental impacts is necessary to appropriately manage their risks. To keep pace with the rapid increase in products utilizing engineered ZnO NPs, rapid in silico toxicity test methods based on knowledge of...
Zinc oxide nanoparticles (ZnO NPs) are widely used in a variety of products, thus understanding their health and environmental impacts is necessary to appropriately manage their risks. To keep pace with the rapid increase in products utilizing engineered ZnO NPs, rapid in silico toxicity test methods based on knowledge of...
Zinc oxide nanoparticles (ZnO NPs) are widely used in a variety of products, thus understanding their health and environmental impacts is necessary to appropriately manage their risks. To keep pace with the rapid increase in products utilizing engineered ZnO NPs, rapid in silico toxicity test methods based on knowledge of...
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data
composition Size dose(ppm) M(24hpf) DP SM N M(120hpf) Y A E Sn J O H B So PF CF P C T SB TR M
Zinc oxide nanoparticles (ZnO NPs) are widely used in a variety of products, thus understanding their health and environmental impacts is necessary to appropriately manage their risks. To keep pace with the rapid increase in products utilizing engineered ZnO NPs, rapid in silico toxicity test methods based on knowledge of...
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S1-EPs data
comp. Size Conc.(ppm) DP SM N Y A E Sn J O H B So PF
Zinc oxide nanoparticles (ZnO NPs) are widely used in a variety of products, thus understanding their health and environmental impacts is necessary to appropriately manage their risks. To keep pace with the rapid increase in products utilizing engineered ZnO NPs, rapid in silico toxicity test methods based on knowledge of...
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., Son, J., Harper, B., Zhou, Z., & Harper, S. (2015). Influence of surface
chemical properties on the
Zinc oxide nanoparticles (ZnO NPs) are widely used in a variety of products, thus understanding their health and environmental impacts is necessary to appropriately manage their risks. To keep pace with the rapid increase in products utilizing engineered ZnO NPs, rapid in silico toxicity test methods based on knowledge of...
Geological carbon sequestration, as a method of atmospheric greenhouse gas reduction, is at the technological forefront of the climate change movement. During sequestration, carbon dioxide (CO₂) gas effluent is captured from coal fired power plants and is injected into a storage saline aquifer or depleted oil reservoir. In an effort...
Gold nanoparticles (AuNPs) are increasingly used in biomedical applications,
hence understanding the processes that affect their biocompatibility and stability are of
significant interest. In this study, we assessed the stability of peptide-capped AuNPs and
used the embryonic zebrafish (Danio rerio) as a vertebrate system to investigate the impact
of synthesis...
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.; Wang, J.; Huo, Q. Extinction coefficient of gold nanoparticles with different
sizes and different
Gold nanoparticles (AuNPs) are increasingly used in biomedical applications,
hence understanding the processes that affect their biocompatibility and stability are of
significant interest. In this study, we assessed the stability of peptide-capped AuNPs and
used the embryonic zebrafish (Danio rerio) as a vertebrate system to investigate the impact
of synthesis...
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Nanoparticles
BryanHarper 1, Federico Sinche 1, Rosina Ho Wu 2, Meenambika Gowrishankar 2,
Grant Marquart 2
Gold nanoparticles (AuNPs) are increasingly used in biomedical applications, hence understanding the processes that affect their biocompatibility and stability are of significant interest. In this study, we assessed the stability of peptide-capped AuNPs and used the embryonic zebrafish (Danio rerio) as a vertebrate system to investigate the impact of synthesis...
BACKGROUND: Predictive modeling of the biological effects of nanomaterials is critical for industry and policymakers to assess the potential hazards resulting from the application of engineered nanomaterials.
METHODS: We generated an experimental dataset on the toxic effects experienced by embryonic zebrafish due to exposure to nanomaterials. Several nanomaterials were studied,...
We used two temporally separated femtosecond pulses to manipulate the waveforms of multi-cycle THz pulses through optical rectification in periodically-poled lithium mobate (PPLN). The relative phase of the THz pulses was controlled by the relative time delay between the optical pulses. This phase adjustability combined with the frequency tunability of...
The integration of rapid assays, large datasets, informatics, and modeling can overcome current barriers in understanding nanomaterial structure–toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard rankings for nanomaterials. Here, we present the use of a rapid, low-cost assay to perform screening-level toxicity evaluations of nanomaterials in vivo. Calculated...
Questions: Are exotic plant species favoured by non-native ungulate herbivores and disadvantaged by native herbivores in forested rangelands? Do the impacts of ungulates on exotic vs native plants depend on forest management activities such as prescribed fire and stand thinning?
Location: Northeastern Oregon, USA.
Methods: We recorded changes in richness...
Questions: Are exotic plant species favoured by non-native ungulate herbivores and disadvantaged by native herbivores in forested rangelands? Do the impacts of ungulates on exotic vs native plants depend on forest management activities such as prescribed fire and stand thinning?
Location: Northeastern Oregon, USA.
Methods: We recorded changes in richness...
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, Catherine G. Parks, Bryan A. Endress & Bridgett J. Naylor
Keywords
Conditioned Correspondence Analysis
Questions: Are exotic plant species favoured by non-native ungulate herbivores and disadvantaged by native herbivores in forested rangelands? Do the impacts of ungulates on exotic vs native plants depend on forest management activities such as prescribed fire and stand thinning?
Location: Northeastern Oregon, USA.
Methods: We recorded changes in richness...
QUESTIONS: Do successional trajectories in plant diversity, heterogeneity and dominance respond differently to ungulate exclusion in unmanaged forests vs managed forests that are thinned and burned? Is vegetation in recently thinned and burned stands more sensitive to changes in the grazing regime? LOCATION: Northeast OR, USA. METHODS: We evaluated changes...
Ungulates exert a strong influence on the composition and diversity of vegetation communities. However, little is known about how ungulate browsing pressure interacts with episodic disturbances such as fire and stand thinning. We assessed shrub responses to variable browsing pressure by cattle and elk in fuels treated (mechanical removal of...
Published May 1955. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Published August 1954. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Published March 1943. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Published January 1944. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Published September 1948. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Published November 1973. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Revised January 1976. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Benthic infaunal communities are important components of coastal ecosystems. Understanding the relationships between the structure of these communities and characteristics of the habitat in which they live is becoming progressively more important as coastal systems face increasing stress from anthropogenic impacts and changes in climate. To examine how sediment characteristics...
Benthic infaunal communities are important components of coastal ecosystems. Understanding the relationships between the structure of these communities and characteristics of the habitat in which they live is becoming progressively more important as coastal systems face increasing stress from anthropogenic impacts and changes in climate. To examine how sediment characteristics...
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. Coblentz1, Jessica R. Henkel2, BryanJ. Sigel3 and Caz M. Taylor2
1 Department of Integrative Biology
Questions: Mountain systems have high abiotic heterogeneity over local spatial scales, offering natural experiments for examining plant species invasions. We ask whether functional groupings explain non-native species spread into native vegetation and up elevation gradients.We examine whether non-native species distribution patterns are related to environmental variables after controlling for elevation...
Benthic infaunal communities are important components of coastal ecosystems. Understanding the relationships between the structure of these communities and characteristics of the habitat in which they live is becoming progressively more important as coastal systems face increasing stress from anthropogenic impacts and changes in climate. To examine how sediment characteristics...
Herbicides are the primary method used to control exotic, invasive plants. This study evaluated restoration efforts applied to grasslands dominated by an invasive plant, sulfur cinquefoil, 6 yr after treatments. Of the five herbicides we evaluated, picloram continued to provide the best control of sulfur cinquefoil over 6 yr. We...
Herbivory by domestic and wild ungulates can dramatically affect vegetation structure, composition and dynamics in nearly every terrestrial ecosystem of the world. These effects are of particular concern in forests of western North America, where intensive herbivory by native and domestic ungulates has the potential to substantially reduce or eliminate...
As we contemplate the future of forest landscapes under changing climate conditions and land-use demands, there is increasing value in studying historic forest conditions and how these landscapes have changed following past disturbances. Historic landscape paintings are a potential source of data on preindustrial forests with highly detailed, full-color depictions...
Published September 1957. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Published December 1977. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Published October 1977. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Laboratory culture experiments were performed to establish the range of growth conditions where ¹³C labeling of di- and tri-unsaturated C₃₇ methyl ketones yields reliable growth rates for alkenone-producing algae. Results document that even at low growth rates and short time intervals, ¹³C labeling of the di-unsaturated C₃₇ alkenone provides reasonable...
Upwelling in eastern boundary current systems is a primary driver of ecosystem productivity. Typically, peak upwelling occurs during spring and summer, but winter upwelling may also be important to ecosystem functions. In this study, we investigated the hypothesis that winter and spring/summer upwelling, operating through indirect trophic interactions, are important...
Published September 1949. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
The internalization of some oomycete and fungal pathogen effectors into host plant cells has been reported to be blocked by proteins that bind to the effectors' cell entry receptor, phosphatidylinositol-3-phosphate (PI3P). This finding suggested a novel strategy for disease control by engineering plants to secrete PI3P-binding proteins. In this study,...
Plant wax lipids and lignin phenols are the two most common classes of molecular markers that are used to trace vascular plant-derived OM in the marine environment. However, their ¹³C and ¹⁴C compositions have not been directly compared, which can be used to constrain the flux and attenuation of terrestrial...
The bivalve Pacific geoduck (Panopea generosa) has been used in the eastern North Pacific Ocean to create proxies for environmental factors such as temperature and oceanographic conditions. This type of research depends upon accurate age determination of Pacific geoducks, which historically was based on shell growth-increment counts. A recent study...
Nitric oxide (NO) is an essential agent of the innate immune system which exhibits multi-mechanistic antimicrobial activity. Previously, increased antimicrobial activity against E. coli with nitric oxide releasing nanoparticles (NO-np) was demonstrated when combined with glutathione, versus NO-np alone, due to formation of S-nitrosoglutathione (GSNO), a potent transnitrosylating agent. To...
FVB/N mice wild-type, heterozygous or null for Cyp 1b1 were used in a two-stage skin tumor study comparing PAH, benzo[a]pyrene (BaP), dibenzo[def,p]chrysene (DBC), and coal tar extract (CTE, SRM 1597a). Following 20 weeks of promotion with TPA the Cyp 1b1 null mice, initiated with DBC, exhibited reductions in incidence, multiplicity,...
A framework for understanding the synthesis and catalysis of metabolites and other biochemicals by proteins is crucial for unraveling the physiology of cells. To create such a framework for Zea mays L. subsp. mays (maize), we developed MaizeCyc, a metabolic network of enzyme catalysts, proteins, carbohydrates, lipids, amino acids, secondary...
BACKGROUND: Plant phenotype datasets include many different types of data, formats, and terms from specialized vocabularies. Because these datasets were designed for different audiences, they frequently contain language and details tailored to investigators with different research objectives and backgrounds. Although phenotype comparisons across datasets have long been possible on a...
To predict future coastal hazards, it is important to quantify any links between climate drivers and spatial patterns of coastal change. However, most studies of future coastal vulnerability do not account for the dynamic components of coastal water levels during storms, notably wave-driven processes, storm surges and seasonal water level...
The Paisley Caves in Oregon record the oldest directly dated human remains (DNA) in the Western Hemisphere. More than 100 high-precision radiocarbon dates show that deposits containing artifacts and coprolites ranging in age from 12,450 to 2295 ¹⁴C years ago are well stratified. Western Stemmed projectile points were recovered in...
Internal gravity waves, the subsurface analogue of the familiar
surface gravity waves that break on beaches, are ubiquitous in
the ocean. Because of their strong vertical and horizontal currents,
and the turbulent mixing caused by their breaking, they affect a
panoply of ocean processes, such as the supply of nutrients...
The future of agricultural research depends on data. The sheer volume of agricultural biological data being produced today makes excellent data management essential. Governmental agencies, publishers and science funders require datamanagement plans for publicly funded research. Furthermore, the value of data increases exponentially when they are properly stored, described, integrated...