Index Catalog // ScholarsArchive@OSU

The role of innate immunity in cnidarian-dinoflagellate symbiosis

Creator:: Poole, Angela Z.
Abstract:: Cnidarians, such as corals and sea anemones serve as hosts to a variety of organisms including symbiotic dinoflagellates, bacteria, virus, and apicomplexans. As corals are vital to the health and productivity of the reef ecosystem it is important to understand how these organisms interact with each component of the holobiont....
Resource Type:: Dissertation
Full Text:: The Role of Innate Immunity in Cnidarian-dinoflagellate

Does intensive forest management affect innate immunity of wild deer mice (Peromyscus maniculatus)?

Creator:: Rogers, Natalie M., Hanselmann, Rhea, and Jolles, Anna E.
Abstract:: To examine the influence of forest management on wildlife immunity, the innate immune system of wild deer mice (Peromyscus maniculatus) inhabiting forest plots of different management intensities in the Oregon coast range was measured by bactericidal assay. Bactericidal activity was compared across three management levels, including 40-50 year old forest...
Resource Type:: Poster

Immediate effects of acute stress on innate immunity in rainbow trout (Oncorhynchus mykiss)

Creator:: Demers, Nora Egan
Abstract:: This thesis tests the hypothesis that innate immunity may be enhanced immediately following a stressful event. The experiments characterize the acute effects of the fight or flight response on some immunological and endocrine parameters in rainbow trout (Oncorhynchus mykiss). Plasma cortisol and catecholamines were elevated within seconds of the initiation...
Resource Type:: Dissertation
Full Text:: Stress on Innate Immunity in Rainbow Trout (Oncorhynchus mykiss) Abstract approved: This thesis tests

Non-specific innate immunity against Escherichia coli infection in white leghorn chickens

Creator:: Huang, Hsuan-Jen
Abstract:: This research was initiated to investigate a high mortality problem occurring in market age broiler chickens in Oregon. Initial field investigations revealed that mortality was due to the systemic bacterial infections. The subsequent laboratory experiments suggested that suppressed short-term, non-specific innate immunity rather than pathogenic properties of bacteria caused the...
Resource Type:: Dissertation
Full Text:: Non-specific innate immunity against Escherichia coli

Temperature stress, gene expression, and innate immunity at the onset of cnidarian-dinoflagellate symbiosis

Creator:: Schnitzler, Christine E.
Abstract:: The intracellular mutualism between cnidarians and photosynthetic dinoflagellates (genus Symbiodinium) is responsible for the physical and trophic structure of diverse coral reef ecosystems. This relationship, based on nutrient exchange, allows for high productivity in tropical waters, which are generally nutrient-poor environments. Numerous environmental stressors currently threaten the health of corals,...
Resource Type:: Dissertation
Full Text:: Zoology presented on June 1, 2010. Title: Temperature Stress, Gene Expression, and Innate Immunity

Characterizing Mycobacterium avium subspecies hominissuis (MAH) Microaggregate Induction of Innate Immunity

Creator:: Keefe, Bailey F.
Abstract:: Bacterial aggregation is a strategy employed by many pathogens to establish infection. Mycobacterium avium subsp. hominissuis (MAH) undergoes a phenotypic change, microaggregation, when exposed to the respiratory epithelium. This aggregation is an important step in the pathogenesis of the infection, laying the foundation for biofilm formation. We therefore compared how...
Resource Type:: Masters Thesis
Full Text:: ) Microaggregate Induction of Innate Immunity Abstract approved

Investigating variation in immunity and infection risk in wild ungulates

Creator:: Dugovich, Brian S.
Abstract:: In the midst of the sixth mass extinction, understanding wildlife disease spillover is critical to maintaining protected wildlife areas. Studying ecoimmunology and wildlife disease ecology helps to understand immune and disease traits in an ecological context, which is invaluable in preventing pathogen spillover between livestock and wildlife. To investigate this...
Resource Type:: Dissertation
Full Text:: investigate this interface, tests of innate immunity were validated in various ungulates and desert bighorn

Roles of Innate Lymphoid Cells on Mycobacterium avium infection

Creator:: Bickell, Jay
Abstract:: Mycobacterium avium subsp. hominissuis (MAH) is a common environmental bacterium that causes infections in immunocompromised patients such as those with HIV/AIDS, or patients with chronic lung disease such as Cystic Fibrosis. There are many strains of MAH with varying levels of virulence. Infection with MAH strains 100 and 104 have...
Resource Type:: Honors College Thesis
Full Text:: of the immune system4. ILCs can be thought of as the bridge that gaps innate and adaptive immunity

Selenium Supplementation Restores Innate and Humoral Immune Responses in Footrot-Affected Sheep

Creator:: Hall, Jean A., Vorachek, William R., Stewart, Whitney C., Gorman, M. Elena, Mosher, Wayne D., Pirelli, Gene J., and Bobe, Gerd
Abstract:: Dietary selenium (Se) alters whole-blood Se concentrations in sheep, dependent upon Se source and dosage administered, but little is known about effects on immune function. We used footrot (FR) as a disease model to test the effects of supranutritional Se supplementation on immune function. To determine the effect of Se-source...
Resource Type:: Article
Full Text:: with different Se sources and dosages (30 ewes/treatment group). Innate immunity was evaluated after 62

Axial organ : its potential role in echnoid immunity

Creator:: Larson, Maureen Kupke
Abstract:: The echinoderm axial organ is located centrally, at the meeting point of the animals' "circulatory" systems. This, and its unusual histology, have prompted the implication of a number of different functions for the organ, including circulation, excretion and host defense. None of these have been definitively proven. Claims that starfish...
Resource Type:: Masters Thesis
Full Text:: The Axial Organ: Its Potential Role In Echinoid Immunity

The Effects of the Immunity Factor Relish on Aging Phenotypes in Drosophila melanogaster

Creator:: Kumar, Nandita
Abstract:: Aging is a complex biological phenomenon that alters many different physiological processes. Although many age-related phenotypes, such as neurodegeneration, weakening circadian rhythms, and inflammaging, are well-studied, the links between them are not. To elucidate these links we created an inflammation-like state in Drosophila melanogaster by overexpressing Relish (Rel), an NFκB...
Resource Type:: Honors College Thesis
Full Text:: factor in the Imd innate immunity pathway. Then we observed how aging parameters such as lifespan

A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins

Creator:: Jing, Maofeng, Guo, Baodian, Li, Haiyang, Yang, Bo, Wang, Haonan, Kong, Guanghui, Zhao, Yao, Xu, Huawei, Wang, Yan, Ye, Wenwu, Dong, Suomeng, Qiao, Yongli, Tyler, Brett M., Ma, Wenbo, and Wang, Yuanchao
Abstract:: Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector...
Resource Type:: Article

Crossing Boundaries during Stress Responses: Antigen Presentation by Adaptive and Innate MHC Class I Molecules

Creator:: Nagamine, Brandy S.
Abstract:: The immune system is a complex network of cellular processes working in harmony to guard us against pathogenic attack. Of utmost importance is the ability of the immune system to discriminate between “self” and “non-self” and diseased versus healthy. Recognition of antigens complexed to major histocompatibility complex (MHC) molecules is...
Resource Type:: Dissertation
Full Text:: 1.1.1 Innate Immunity………...…………………………………………………2 1.1.2 Adaptive Immunity

Innate and adaptive immune responses in migrating spring-run adult chinook salmon, Oncorhynchus tshawytscha

Creator:: Dolan, Brian P., Fisher, Kathleen M., Colvin, Michael E., Benda, Susan E., Peterson, James T., Kent, Michael L., and Schreck, Carl B.
Abstract:: Adult Chinook salmon (Oncorhynchus tshawytscha) migrate from salt water to freshwater streams to spawn. Immune responses in migrating adult salmon are thought to diminish in the run up to spawning, though the exact mechanisms for diminished immune responses remain unknown. Here we examine both adaptive and innate immune responses as...
Resource Type:: Article
Full Text:: elevate innate immune responses, but in general pathogens do not drive the rapid loss of innate immunity

Regulation of cnidarian–dinoflagellate mutualisms: Evidence that activation of a host TGFβ innate immune pathway promotes tolerance of the symbiont

Creator:: Detournay, Olivier, Schnitzler, Christine E., Poole, Angela, and Weis, Virginia M.
Abstract:: Animals must manage interactions with beneficial as well as detrimental microbes. Immunity therefore includes strategies for both resistance to and tolerance of microbial invaders. Transforming growth factor beta (TGFβ) cytokines have many functions in animals including a tolerance-promoting (tolerogenic) role in immunity in vertebrates. TGFβ pathways are present in basal...
Resource Type:: Article

Wildlife Health in Managed Forests : Immunity and Infectious Diseases in Wild Rodents of Oregon

Creator:: Hanselmann, Rhea
Abstract:: With continual and worldwide human population growth, our impact on the natural environment expands and intensifies every day. We consume natural resources, burn fossil fuels, and release toxic compounds into the air, water, and earth. We build roads that fragment the landscape, construct new settlements, and develop agricultural lands in...
Resource Type:: Dissertation
Full Text:: immediately deployable innate defenses. For a short-lived species such as the tree vole, innate immunity is

Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut

Creator:: Shulzhenko, Natalia, Morgun, Andrey, Hsiao, William, Battle, Michele, Yao, Michael, Gavrilova, Oksana, Orandle, Marlene, Mayer, Lloyd, Macpherson, Andrew J, McCoy, Kathy D., Fraser-Liggett, Claire, and Matzinger, Polly
Abstract:: Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium and the microbiota. We found that, in the absence of B cells, or of IgA, and in the presence of the microbiota, the intestinal epithelium launches its own protective mechanisms, upregulating...
Resource Type:: Article
Full Text:: lipid metabolism (mostly regulated by Gata4) and one governing innate immunity (mostly made up of IFN

The Role of Mesenchymal Stem Cells in Anti-Tumor Immunity of Canine Osteosarcoma

Creator:: Allende, Carolina M.
Abstract:: Osteosarcoma (OS) is the most common primary bone tumor in both humans and dogs, occurring approximately 10 times more frequently in dogs. OS is a highly aggressive neoplasm with evidence of metastasis often found at the time of diagnosis. Long-term survival in afflicted dogs continues to remain low despite aggressive...
Resource Type:: Masters Thesis
Full Text:: presented on June 5, 2020. Title: The Role of Mesenchymal Stem Cells in Anti-Tumor Immunity of Canine

Dow_Ellen HHMI 2012[2].pdf

Creator:: Dow, Ellen
Abstract:: Keywords: Cnidarian immunity, Complement molecules
Full Text:: snf.fra.affrc.go.jp Immunity: Complement System •  Innate immune pathway •  Three distinct mechanisms of

Dow_Ellen HHMI 2012.ppt

Creator:: Dow, Ellen
Abstract:: Keywords: Cnidarian immunity, Complement molecules
Full Text:: potential to be involved is the complement system, which is what my research focuses on. Innate immunity is

Effect of selenium source and supplementation rate in ewes on selenium status, passive immunity and growth performance of their lambs

Creator:: Stewart, Whitney C.
Abstract:: Selenium (Se) is an essential micronutrient of sheep. Supplementation is especially important in young lambs in order to prevent Se-deficiency signs. In the United States, the FDA regulates Se supplementation to ruminant diets at a level of 0.3 mg/kg Se (as fed basis). Questions still exist regarding what chemical form...
Resource Type:: Masters Thesis
Full Text:: , Source and Supplementation Rate on Selenium Transfer, Passively Transferred Immunity and Ewe and Lamb

Rogers TWS Final PDF.pdf

Creator:: Rogers, Natalie M., Hanselmann, Rhea, and Jolles, Anna E.
Abstract:: To examine the influence of forest management on wildlife immunity, the innate immune system of wild deer mice (Peromyscus maniculatus) inhabiting forest plots of different management intensities in the Oregon coast range was measured by bactericidal assay. Bactericidal activity was compared across three management levels, including 40-50 year old forest...
Full Text:: prevalence and risk of transmission. Innate Immunity Adaptive Immunity The Immune System

Rogers TWS Final.pptx

Creator:: Rogers, Natalie M., Hanselmann, Rhea, and Jolles, Anna E.
Abstract:: To examine the influence of forest management on wildlife immunity, the innate immune system of wild deer mice (Peromyscus maniculatus) inhabiting forest plots of different management intensities in the Oregon coast range was measured by bactericidal assay. Bactericidal activity was compared across three management levels, including 40-50 year old forest...

Trade-offs in a pathogen-rich world : genetic and maternal drivers of variation in costly resistance and immunity in African buffalo (Syncerus caffer)

Creator:: Tavalire, Hannah F.
Abstract:: Disease acts as a powerful selective force in natural systems, driving the rapid evolution of resistance in the host. In the face of a myriad of pathogenic challenges in natural systems, hosts must balance the energetic needs of maintenance and reproduction with costly resistance mechanisms. In this dissertation I will...
Resource Type:: Dissertation
Full Text:: , J.B., Ricklefs, R.E., Klasing, K.C., 2005. Constitutive innate immunity is a component of the pace

Effects of selenium supplementation during different trimesters of pregnancy on non-specific humoral immunity of pregnant beef cows and persistence of antibodies in their newborn calves

Creator:: Thompson-Hernandez, Ian
Abstract:: Immunosuppression during the periparturient period leads to increased susceptibility to infectious diseases in beef cows. Newborn calves rely on passive transfer of antibodies from their mothers at birth for protection against diseases in the first two months of age. It is unknown if supranutritional Se supplementation of cows during pregnancy...
Resource Type:: Honors College Thesis
Full Text:: trimesters of pregnancy on non- specific humoral immunity of pregnant beef cows and persistence of

JingPhytophthoraSojaeEffector.pdf

Creator:: Jing, Maofeng, Guo, Baodian, Li, Haiyang, Yang, Bo, Wang, Haonan, Kong, Guanghui, Zhao, Yao, Xu, Huawei, Wang, Yan, Ye, Wenwu, Dong, Suomeng, Qiao, Yongli, Tyler, Brett M., Ma, Wenbo, and Wang, Yuanchao
Abstract:: Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector...
Full Text:: of specific effector proteins to manipulate host innate immunity to promote pathogen colonization

JingPhytophthoraSojaeEffectorSuppFigures1-14andTables1-2.pdf

Creator:: Jing, Maofeng, Guo, Baodian, Li, Haiyang, Yang, Bo, Wang, Haonan, Kong, Guanghui, Zhao, Yao, Xu, Huawei, Wang, Yan, Ye, Wenwu, Dong, Suomeng, Qiao, Yongli, Tyler, Brett M., Ma, Wenbo, and Wang, Yuanchao
Abstract:: Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector...

Predicting Protein-Protein Interactions in a Cnidarian Model System

Creator:: Gregory, Dylan B.
Abstract:: The symbiotic sea anemone Exaiptasia diaphana (Aiptasia) is a model organism used to better understand cnidarian-algal symbiosis and coral bleaching (dysbiosis). Many biological processes are hypothesized to be involved in coral dysbiosis, and the innate immunity is a key area of interest. Rab proteins are small proteins with GTPase domains,...
Resource Type:: Honors College Thesis
Full Text:: innate immunity responses including phagocytosis and endocytosis and have been previously observed to

Identification of Mycobacterium smegmatis Surface Proteins for Stimulation of Anti-Mycobacterial Killing Activity of Macrophages

Creator:: Islam, Sabrina
Abstract:: Mycobacterium avium subspecies hominissuis (M. avium) is a ubiquitous, acid-fast organism found in water and soil. This opportunistic pathogen is a common causative of pulmonary diseases in immunocompromised individuals and prevalent infection in HIV/AIDS patients. As a primary defense response against infection, immune cells such as macrophages phagocytize M. avium...
Resource Type:: Masters Thesis
Full Text:: . Studies have demonstrated the possibility to “train” innate immunity by stimulating defensive signaling

Gene expression associated with white syndromes in a reef building coral, Acropora hyacinthus

Creator:: Wright, Rachel M., Aglyamova, Galina V., Meyer, Eli, and Matz, Mikhail V.
Abstract:: Background: Corals are capable of launching diverse immune defenses at the site of direct contact with pathogens, but the molecular mechanisms of this activity and the colony-wide effects of such stressors remain poorly understood. Here we compared gene expression profiles in eight healthy Acropora hyacinthus colonies against eight colonies exhibiting...
Resource Type:: Article
Full Text:: indicate activation of several innate immunity and tissue repair pathways accompanied by reduced

Environmental immune disruptors, inflammation and cancer risk

Creator:: Thompson, Patricia A., Khatami, Mahin, Baglole, Carolyn J., Jun Sun,, Harris, Shelley A., Moon, Eun-Yi, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Brown, Dustin G., Colacci, Annamaria, Mondello, Chiara, Raju, Jayadev, Ryan, Elizabeth P., Woodrick, Jordan, Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Salem, Hosni K., Amedei, Amedeo, Hamid, Roslida A., Lowe, Leroy, Guarnieri, Tiziana, and Bisson, William H.
Abstract:: An emerging area in environmental toxicology is the role that chemicals and chemical mixtures have on the cells of the human immune system. This is an important area of research that has been most widely pursued in relation to autoimmune diseases and allergy/asthma as opposed to cancer causation. This is...
Resource Type:: Article
Full Text:: despite the well-recognized role that innate and adaptive immunity play as essential factors in

The Role of the Mucosal Immunoglobulin IgT and Inflammatory Cytokines in Ceratonova shasta Infections in Rainbow Trout

Creator:: Taggart-Murphy, Laura M.
Abstract:: The myxozoan parasite Ceratonova shasta threatens both juvenile and adult salmonid populations in the Pacific Northwest region of the United States, causing intestine necrosis and hemorrhaging, along with high mortality in some fish strains. It induces an inflammatory tissue response in susceptible strains of fish; understanding the interactions between C....
Resource Type:: Masters Thesis
Full Text:: regulate other components of both innate and adaptive immunity. Pathogen-specific B and T cells comprise

The effects of elevated temperature and stress on immune function in juvenile chinook salmon (Oncorhynchus tshawytscha)

Creator:: Harrahy, Laura Nicole Martini
Abstract:: Stress, including extreme or rapidly changing temperatures, are known to have deleterious effects on fish health and physiology. This thesis examines the combined effects of elevated acclimation temperature and acute handling stress on the number of antibody producing cells, plasma lysozyme concentrations, and the number of pronephric leukocytes in juvenile...
Resource Type:: Masters Thesis
Full Text:: instigator of thermal shock, on innate immunity 10 wild fall chinook salmon of the Columbia River

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

Creator:: Guo, Chunxiao
Abstract:: Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
Resource Type:: Dissertation
Full Text:: essential role in innate immunity. Mice lacking the cathelicidin gene are more susceptible to skin

The Plant Actin Cytoskeleton Responds to Signals from Microbe-Associated Molecular Patterns

Creator:: Henty-Ridilla, Jessica L., Shimono, Masaki, Li, Jiejie, Chang, Jeff H., Day, Brad, and Staiger, Christopher J.
Abstract:: Plants are constantly exposed to a large and diverse array of microbes; however, most plants are immune to the majority of potential invaders and susceptible to only a small subset of pathogens. The cytoskeleton comprises a dynamic intracellular framework that responds rapidly to biotic stresses and supports numerous fundamental cellular...
Resource Type:: Article
Full Text:: innate immunity against fungi and oomycetes, based largely on static images and pharmacological studies

Mycobacterium avium subsp hominissuis effector MAVA5_06970 promotes rapid apoptosis in secondary-infected macrophages during cell-to-cell spread

Creator:: Danelishvili, Lia, Rojony, Rajoana, Carson, Kylee L., Palmer, Amy L., Rose, Sasha J., and Bermudez, Luiz E.
Abstract:: Mycobacterium avium subsp, hominissuis is an opportunistic intracellular pathogen associated with disease in patients either immunosuppression or chronic lung pathology. Once in the host, M. avium preferentially infects and replicates within the phagocytic cells. The host driven macrophage apoptosis appears to be an essential aspect of innate immunity during bacterial...
Resource Type:: Article
Full Text:: cells. The host driven macrophage apop- tosis appears to be an essential aspect of innate immunity

Behavioral and physiological response to immune challenge in T.s. parietalis

Creator:: Schulden, Stephanie, Blakemore, Leslie, and Mason, Robert
Abstract:: Fever responses to an immune challenge have been studied in endothermic creatures, but studies of the equivalence is lacking in ectotherms. In this study, heterophil counts were shown to be significantly higher in individuals immune challenged with LPS when compared to a control group. This is indicative of an innate...
Resource Type:: Poster
Full Text:: challenged with LPS when compared to a control group. This is indicative of an innate immune response

Enemies and Turncoats: Bovine tuberculosis exposes pathogenic potential of Rift Valley fever virus in a common host, African Buffalo (Syncerus caffer)

Creator:: Beechler, B. R., Manore, C. A., Reininghaus, B., O'Neal, D., Gorsich, E. E., Ezenwa, V. O., and Jolles, A. E.
Abstract:: The ubiquity and importance of parasite co-infections in populations of free-living animals is beginning to be recognized, but few studies have demonstrated differential fitness effects of single infection versus co-infection in free-living populations. We investigated interactions between the emerging bacterial disease bovine tuberculosis (BTB) and the previously existing viral disease...
Resource Type:: Article
Full Text:: interactions, 12 since animals with BTB had decreased innate immunity and increased pro-inflammatory immune

Evolution and Expression of TSR-domain proteins in cnidarian-dinoflagellate symbiosis

Creator:: Tan, Kenneth
Abstract:: The symbiotic relationship between cnidarians, such as corals and sea anemones, and dinoflagellates plays a crucial role in supporting the diversity and productivity of coral reefs. Critical to the symbiosis is the recognition process between host and symbiont at the onset of symbiosis, which involves the host innate immune system....
Resource Type:: Poster
Full Text:: , which involves the host innate immune system. One potential group of immune proteins in cnidarians are

Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway

Creator:: Guo, Chunxiao, Rosoha, Elena, Lowry, Malcolm B., Borregaard, Niels, and Gombart, Adrian F.
Abstract:: The vitamin D receptor (VDR) mediates the pleiotropic biologic effects of 1alpha,25 dihydroxy-vitamin D3. Recent in vitro studies suggested that curcumin and poly-unsaturated fatty acids (PUFAs) also bind to VDR with low affinity. As potential ligands for the VDR, we hypothesized that curcumin and PUFAs would induce expression of known...
Resource Type:: Article
Full Text:: by NIH grant 5R01AI65604 (A.F.G.). Keywords innate immunity, vitamin D receptor, curcumin

Jenny Tran HHMI Presentation- final.pdf

Creator:: Tran, Jenny K. and Gombart, Adrian F.
Abstract:: In this study, the gene expression levels between 6 month old mice and 26 month old mice were compared. The purpose of this research was to identify genes that are differentially regulated due to aging. The results showed 148 significantly differentiated genes in the analysis of a total of 44,170...
Full Text::   Decline in adaptive immunity  Highly specialized systemic cells and processes

The Role of Complement in Cnidarian-Dinoflagellate Symbiosis and Immune Challenge in the Sea Anemone Aiptasia pallida

Creator:: Poole, Angela Z., Kitchen, Sheila A., and Weis, Virginia M.
Abstract:: The complement system is an innate immune pathway that in vertebrates, is responsible for initial recognition and ultimately phagocytosis and destruction of microbes. Several complement molecules including C3, Factor B, and mannose binding lectin associated serine proteases (MASP) have been characterized in invertebrates and while most studies have focused on...
Resource Type:: Article
Full Text:: host-microbe interactions. Keywords: Aiptasia, symbiosis, complement, innate immunity, cnidarians

Jenny Tran HHMI 2012 Report-FINAL.pdf

Creator:: Tran, Jenny K. and Gombart, Adrian F.
Abstract:: In this study, the gene expression levels between 6 month old mice and 26 month old mice were compared. The purpose of this research was to identify genes that are differentially regulated due to aging. The results showed 148 significantly differentiated genes in the analysis of a total of 44,170...
Full Text:: genes with 16 genes found to be related to immunity and inflammation. Introduction As we age

DetournayOlivierZoologyRegulationCnidarianDinoflagellate.pdf

Creator:: Detournay, Olivier, Schnitzler, Christine E., Poole, Angela, and Weis, Virginia M.
Abstract:: Animals must manage interactions with beneficial as well as detrimental microbes. Immunity therefore includes strategies for both resistance to and tolerance of microbial invaders. Transforming growth factor beta (TGFβ) cytokines have many functions in animals including a tolerance-promoting (tolerogenic) role in immunity in vertebrates. TGFβ pathways are present in basal...
Full Text:: : Aiptasia, cnidarian, coral bleaching, dinoflagellate, innate immunity, Nematostella, Smads, Symbiodinium

Immunology beliefs as a factor in vaccine opposition among complementary and alternative medical providers

Creator:: Bean, Sandra J. and Catania, Joseph A.
Abstract:: Objectives: Parental pediatric vaccine decisions are influenced by parents' health provider networks. Complementary and alternative medical providers may be key influences in the networks of those parents who do not vaccinate their children. Methods: From March to July 2013, we conducted semi-structured interviews of Oregon complementary and alternative medical providers...
Resource Type:: Article
Full Text:: . Of course, this is the definition of innate immunity39 as contrasted with immunity acquired from a

Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions

Creator:: Kravchenko, Julia, Corsini, Emanuela, Williams, Marc A., Bisson, William H., Decker, William, Manjili, H. Masoud, Otsuki, Takemi, Sing, Neetu, Al-Mulla, Faha, Al-Temaimi, Rabeah, Amedei, Amedeo, Colacci, Anna Maria, Vaccari, Monica, Mondello, Chiara, Scovassi, A. Ivana, Raju, Jayadev, Hamid, Roslida A., Memeo, Lorenzo, Forte, Stefano, Roy, Rabindra, Woodrick, Jordan, Salem, Hosni K., Ryan, Elizabeth P., Brown, Dustin G., Bisson, william H., Lowe, Leroy, and Lyerly, H. Kim
Abstract:: An increasing number of studies suggest an important role of host immunity as a barrier to tumor formation and progression. Complex mechanisms and multiple pathways are involved in evading innate and adaptive immune responses, with a broad spectrum of chemicals displaying the potential to adversely influence immunosurveillance. The evaluation of...
Resource Type:: Article
Full Text:: of studies suggest an important role of host immunity as a barrier to tumor formation and

Prospective Evaluation of the Lymph Node Proteome in Dogs with Multicentric Lymphoma Supplemented with Sulforaphane

Creator:: Parachini-Winter, Cyril
Abstract:: Lymphoma (LSA) is one of the most common canine malignancies, and is almost invariably a terminal disease. Epigenetic changes in canine and human lymphomas have been linked to disease progression and poor prognosis, leading to the development of epigenetic-targeted therapies which have shown promise in treating various forms of human...
Resource Type:: Masters Thesis
Full Text:: . Recurrent biological functions for the proteins and gene sets identified included regulation of innate or

The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

Creator:: Rouches, Miles V.
Abstract:: The gut microbiome influences human disease including Type 2 diabetes, obesity and metabolic syndrome and interacts with the innate immune system. The human cathelicidin antimicrobial peptide (hCAMP), an important component of the innate immune system, and vitamin D and xanthohumol, a natural compound found in beer hops, regulate its expression....
Resource Type:: Honors College Thesis
Full Text:: Words: Microbiome, Innate Immunity, 16s rRNA Corresponding e-mail address: rouchemi@oregonstate.edu

StPIP1, a PAMP-induced peptide in potato, elicits plant defenses and is associated with disease symptom severity in a compatible interaction with potato virus Y

Creator:: Combest, Max M., Moroz, Natalia, Tanaka, Kiwamu, Rogan, Conner J., Anderson, Jeffrey C., Thura, Lin, Rakotondrafara, Aurélie M., and Goyer, Aymeric
Abstract:: The role of small secreted peptides in plant defense responses to viruses has been seldom investigated. Here, we report a role for potato (Solanum tuberosum) PIP1, a gene predicted to encode a member of the PAMP-induced peptide (PIP) family, in the response of potato to potato virus Y infection (PVY)....
Resource Type:: Article
Full Text:: immunity, and show that it has a role in the determination of tolerance versus sensitivity. 35 Abstract

Importance of TLR2 and TLR4 signaling against M. abscessus infection of macrophages and use of mycobacteriophage genomics toward understanding some of the aspects of phage therapy

Creator:: Kapoor, Hannah A.
Abstract:: Mycobacterium abscessus (MAB) is an opportunistic pathogen responsible for infections in immunocompromised or immunosuppressed patients. Even with long-term treatment with multiple antibiotics, MAB pulmonary infections have high rates of treatment failure. Within the host, MAB is phagocytosed by key innate immune cells macrophages. The TLR2 and TLR4 are two critical...
Resource Type:: Honors College Thesis
Full Text:: host, MAB is phagocytosed by key innate immune cells macrophages. The TLR2 and TLR4 are two critical

Acute phase proteins in rainbow trout (Oncorhynchus mykiss)

Creator:: Gerwick, Lena
Abstract:: The acute phase response (APR) includes an early response of the innate immune system to an inflammatory agent. Acute phase proteins (APP) are produced at increased rates in the liver during this response. The APR has been well characterized in mammals, but it is unclear to what degree teleosts mount...
Resource Type:: Dissertation
Full Text:: , 1997). The hepatic acute phase response. Humoral components of innate immunity are not limited by

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

Creator:: Campbell, Yan
Abstract:: The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
Resource Type:: Dissertation
Full Text:: microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25

Nicole Rinaldi Thesis.pdf

Creator:: Rinaldi, Nicole A.
Abstract:: Zinc is an essential micronutrient required for many cellular functions, including the development and function of the immune system. The biological consequences of zinc deficiency illustrate the significance of zinc in human health. Zinc deficiency has been shown to cause the dysregulation of both innate and adaptive immune responses, as...
Full Text:: innate and adaptive immune responses, as well as promote the development of chronic low-grade

Molecular investigation of the cnidarian-dinoflagellate symbiosis and the identification of genes differentially expressed during bleaching in the coral Montipora capitata

Creator:: Hauck, Laura L.
Abstract:: Cnidarians, such as anemones and corals, engage in an intracellular symbiosis with photosynthetic dinoflagellates. Corals form both the trophic and structural foundation of reef ecosystems. Despite their environmental importance, little is known about the molecular basis of this symbiosis. In this dissertation we explored the cnidariandinoflagellate symbiosis from two perspectives:...
Resource Type:: Dissertation
Full Text:: complement pathway active in innate immunity in animals. In addition, we have isolated many novel

LiPeripartalRumenProtectedTablesS1-S5.pdf

Creator:: Li, Cong, Batistel, Fernanda, Osorio, Johan Samir, Drackley, James K., Luchini, Daniel, and Loor, Juan J.
Abstract:: Background: Main objectives were to determine to what extent Smartamine M (SM) supplementation to a prepartal higher-energy diet could alter neutrophil (PMN) and liver tissue immunometabolic biomarkers, and whether those responses were comparable to those in cows fed a prepartal lower-energy diet (CON). Results: Twenty-eight multiparous Holstein cows were fed...
Full Text:: of stimuli related to many biological processes such as inflammation, immunity, differentiation

SmithKristinaBiochemBiophysThermalStressTriggers.pdf

Creator:: Vidal-Dupiol, Jeremie, Dheilly, Nolwenn M., Rondon, Rodolfo, Smith, Kristina M., Freitag, Michael, and et al.
Abstract:: Global change and its associated temperature increase has directly or indirectly changed the distributions of hosts and pathogens, and has affected host immunity, pathogen virulence and growth rates. This has resulted in increased disease in natural plant and animal populations worldwide, including scleractinian corals. While the effects of temperature increase...
Full Text:: -regulation of genes involved in innate immunity and apoptosis (Table 3). These observations support the

LiPeripartalRumenProtected.pdf

Creator:: Li, Cong, Batistel, Fernanda, Osorio, Johan Samir, Drackley, James K., Luchini, Daniel, and Loor, Juan J.
Abstract:: Background: Main objectives were to determine to what extent Smartamine M (SM) supplementation to a prepartal higher-energy diet could alter neutrophil (PMN) and liver tissue immunometabolic biomarkers, and whether those responses were comparable to those in cows fed a prepartal lower-energy diet (CON). Results: Twenty-eight multiparous Holstein cows were fed...
Full Text:: greater expression of TLR4 on d 3, key for activation of innate immunity due to inflammation, in OVE

Nicole Rinaldi Thesis Seminar.pdf

Creator:: Rinaldi, Nicole A.
Abstract:: Zinc is an essential micronutrient required for many cellular functions, including the development and function of the immune system. The biological consequences of zinc deficiency illustrate the significance of zinc in human health. Zinc deficiency has been shown to cause the dysregulation of both innate and adaptive immune responses, as...
Full Text:: atrophy, resulting in weakened defense against pathogens  Zinc deficiency causes hyperactive innate

Peripartal rumen-protected methionine supplementation to higher energy diets elicits positive effects on blood neutrophil gene networks, performance and liver lipid content in dairy cows

Creator:: Li, Cong, Batistel, Fernanda, Osorio, Johan Samir, Drackley, James K., Luchini, Daniel, and Loor, Juan J.
Abstract:: Background: Main objectives were to determine to what extent Smartamine M (SM) supplementation to a prepartal higher-energy diet could alter neutrophil (PMN) and liver tissue immunometabolic biomarkers, and whether those responses were comparable to those in cows fed a prepartal lower-energy diet (CON). Results: Twenty-eight multiparous Holstein cows were fed...
Resource Type:: Article

Mycobacterium avium Biofilm Attenuates Mononuclear Phagocyte Function by Triggering Hyperstimulation and Apoptosis during Early Infection

Creator:: Rose, Sasha J. and Bermudez, Luiz E.
Abstract:: Mycobacterium avium subsp. hominissuis is an opportunistic human pathogen that has been shown to form biofilm in vitro and in vivo. Biofilm formation in vivo appears to be associated with infections in the respiratory tract of the host. The reasoning behind how M. avium subsp. hominissuis biofilm is allowed to...
Resource Type:: Article
Full Text:: and Immunity, 82(1), 405-412. doi:10.1128/IAI.00820-13 10.1128/IAI.00820-13 American Society for

ZengNovelLociPathways.pdf

Creator:: Zeng, Yi, Nie, Chao, Min, Junxia, Liu, Xiaomin, Li, Mengmeng, Chen, Huashuai, Xu, Hanshi, Wang, Mingbang, Ni, Ting, Li, Yang, Yan, Han, Zhang, Jin-Pei, Song, Chun, Chi, Li-Qing, Wang, Han-Ming, Dong, Jie, Zheng, Gu-Yan, Lin, Li, Qian, Feng, Qi, Yanwei, Liu, Xiao, Cao, Hongzhi, Wang, Yinghao, Zhang, Lijuan, Li, Zhaochun, Zhou, Yufeng, Wang, Yan, Lu, Jiehua, Li, Jianxin, Qi, Ming, Bolund, Lars, Yashin, Anatoliy, Land, Kenneth C., Gregory, Simon, Yang, Ze, Gottschalk, William, Tao, Wei, Wang, Jian, Wang, Jun, Xu, Xun, Bae, Harold, Nygaard, Marianne, Christiansen, Lene, Christensen, Kaare, Franceschi, Claudio, Lutz, Michael W., Gu, Jun, Tan, Qihua, Perls, Thomas, Sebastiani, Paola, Deelen, Joris, Slagboom, Eline, Hauser, Elizabeth, Xu, Huji, Tian, Xiao-Li, Yang, Huanming, and Vaupel, James W.
Abstract:: Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the...
Full Text:: Chinese. The association with longevity of three of these four pathways (MAPK; immunity; calcium

Antimicrobial peptide regulation by small molecules in humans and other primates

Creator:: Sinnott, Brian D.
Abstract:: Antimicrobial peptides (AMPs) play an important role in the innate immune system. Determining the pathways by which these proteins are regulated allows for modulation of their expression for better health. Two families of antimicrobial peptides have been studied in humans: cathelicidins and defensins. There is a single cathelicidin in humans...
Resource Type:: Masters Thesis
Full Text:: important to innate immunity, such as epithelial cells, macrophages and neutrophils [15-25]. The CAMP

Test for Transgenerational Immune Priming in the Snail, Biomphalaria glabrata

Creator:: Anand, Sonal
Abstract:: Transgenerational immune priming occurs when an adult is exposed to a parasite or other pathogen and then transmits information to its offspring through protective phenotypes to cope with the same pathogen (Moret, 2006). There has been evidence for transgenerational immune priming in various invertebrates (Tidbury et al. 2011). Here we...
Resource Type:: Honors College Thesis
Full Text:: Biomphalaria Glabrata Snail.” Journal of Innate Immunity 5.3 (2013): 261–276. Web. 4 Apr. 2016. 8. Tidbury

Identification and characterization of type III effector proteins in plant-associated bacteria

Creator:: Thomas, William J.
Abstract:: Symbioses between microbes and multicellular eukaryotes are found in all biomes, and encompass a spectrum of symbiotic lifestyles that includes parasitism and disease, commensalism, and mutually beneficial interdependent host-microbe relationships. Regardless of outcome, these symbiotic lifestyles are governed by a complex molecular "courtship" between microbe and potential host. This courtship...
Resource Type:: Dissertation
Full Text:: . Host immunity poses a formidable barrier to the establishment of host-microbe relationships, and the

Initiation of coral/algal symbioses : the role of cell surface lectin/glycan interactions in recognition and specificity

Creator:: Wood-Charlson, Elisha M.
Abstract:: Mutualistic associations between cnidarians, such as corals, and photosynthetic dinoflagellate algae provide the trophic and structural foundation of coral reef ecosystems. In many cases, this intracellular mutualism is highly specific and must be established anew for each generation of host corals. The ability to maintain partner specificity across generations implies...
Resource Type:: Dissertation
Full Text:: the context of cnidarian innate immunity and parallels between the onset of mutualistic symbioses

Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

Creator:: Garland, Michael A.
Abstract:: Zebrafish are capable of fully regenerating organs and tissue such as their caudal fin, which is similar to a human regrowing an arm or a leg. In contrast, most mammals including humans have a greatly reduced capacity for wound healing. The ability of zebrafish to undergo this regenerative process, called...
Resource Type:: Dissertation
Full Text:: that were predicted to target eya4, which is involved in chromatin remodeling and innate immunity

ChristieSingleGenerationDomestication.pdf

Creator:: Christie, Mark R., Marine, Melanie L., Fox, Samuel E., French, Rod A., and Blouin, Michael S.
Abstract:: The genetic underpinnings associated with the earliest stages of plant and animal domestication have remained elusive. Because a genome-wide response to selection can take many generations, the earliest detectable changes associated with domestication may first manifest as heritable changes to global patterns of gene expression. Here, to test this hypothesis,...
Full Text:: responses in wound healing, immunity and metabolism. These findings suggest that the earliest stages of

Identification of Mycobacterium avium genes associated with resistance to host antimicrobial peptides

Creator:: Motamedi, Nima, Danelishvili, Lia, and Bermudez, Luiz E.
Abstract:: Antimicrobial peptides are an important component of the innate immune defense. Mycobacterium avium subsp hominissuis (M. avium) is an organism that establishes contact with the respiratory and gastrointestinal mucosa as a necessary step for infection. M. avium is resistant to high concentrations of polymyxin B, a surrogate for antimicrobial peptides....
Resource Type:: Article
Full Text:: . Innate immunity 16, 235-247. 333 Ashitani, J., Mukae, H., Hiratsuka, T., Nakazato, M., Kumamoto, K

S-nitrosocaptopril nanoparticles as nitric oxide-liberating and transnitrosylating anti-infective technology

Creator:: Mordorski, Breanne, Pelgrift, Robert, Adler, Brandon, Krausz, Aimee, da Costa Neto, Alexandre Batista, Liang, Hongying, Gunther, Leslie, Clendaniel, Alicea, Harper, Stacey, Friedman, Joel M., Nosanchuk, Joshua D., Nacharaju, Parimala, and Friedman, Adam J.
Abstract:: Nitric oxide (NO) is an essential agent of the innate immune system which exhibits multi-mechanistic antimicrobial activity. Previously, increased antimicrobial activity against E. coli with nitric oxide releasing nanoparticles (NO-np) was demonstrated when combined with glutathione, versus NO-np alone, due to formation of S-nitrosoglutathione (GSNO), a potent transnitrosylating agent. To...
Resource Type:: Article
Full Text:: for type 2 NO synthase for IL- 12 signaling in innate immunity. Science. May 7 1999;284(5416):951-955

ConleyAgingSerumMCP1.pdf

Creator:: Conley, Melissa N., Wong, Carmen P., Duyck, Kyle M., Hord, Norman, Ho, Emily, and Sharpton, Thomas J.
Abstract:: Introduction. Age is the primary risk factor for major human chronic diseases, including cardiovascular disorders, cancer, type 2 diabetes, and neurodegenerative diseases. Chronic, low-grade, systemic inflammation is associated with aging and the progression of immunosenescence. Immunosenescence may play an important role in the development of age-related chronic disease and the...
Full Text:: , Geriatrics, Immunology Keywords Aging, Inflammation, Inflammaging, Microbiome, Immunity, Immunosenescence

C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice

Creator:: Kyme, Pierre, Thoennissen, Nils H., Tseng, Ching Wen, Thoennissen, Gabriela B., Wolf, Andrea J., Shimada, Kenichi, Krug, Utz O., Lee, Kunik, Muller-Tidow, Carsten, Berdel, Wolfgang E., Hardy, W. David, Gombart, Adrian F., Koeffler, H. Phillip, and Liu, George Y.
Abstract:: The myeloid-specific transcription factor, CCAAT/enhancer-binding protein epsilon (C/EBPε) is a critical mediator of myelopoiesis. Mutation of this gene is responsible for neutrophil-specific granule deficiency in humans, a condition that confers susceptibility to Staphylococcus aureus infection. We found that C/EBPε-deficient mice are severely affected by infection with S. aureus, and C/EBPε...
Resource Type:: Article
Full Text:: that C/EBPε is an impor- tant target to boost killing of bacteria by the innate immune system

GombartAdrianBiochemistryBiophysicsRegulationAntimicrobialPeptides.pdf

Creator:: Campbell, Yan, Fantacone, Mary L., and Gombart, Adrian F.
Abstract:: Background: Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense and deficiencies lead to increased susceptibility to infection. In addition to their ability to disrupt the integrity of bacterial, viral and fungal membranes, AMPs...
Full Text:: ) Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 3:710-720. doi 10.1038/nri1180

Understanding the Role of the Immune System in the Development of Cancer: New Opportunities for Population-Based Research

Creator:: Michaud, Dominique S., Houseman, E. Andres, Marsit, Carmen J., Nelson, Heather H., Wiencke, John K., and Kelsey, Karl T.
Abstract:: Understanding the precise role of the immune system in cancer has been hindered by the complexity of the immune response and challenges in measuring immune cell types in health and disease in the context of large epidemiologic studies. In this review, we present the rationale to study immunity in cancer...
Resource Type:: Article
Full Text:: role in innate immunity, it is now recognized that these cells have a “memory” and play a role in

Prenatal and Early-life Metals Exposure and Immune Function in Children

Creator:: Welch, Barrett M.
Abstract:: Immune system development during prenatal and early-life periods are essential for healthy development. Environmental and nutritional factors during these periods have strong influences on immune development and can have impacts on disease susceptibility for an individual throughout adulthood. Globally, hundreds of millions of people experience elevated environmental exposure to arsenic,...
Resource Type:: Dissertation
Full Text:: , the impaired innate immunity, shift from Th1 to Th2 responses, sensitive T- cell development period

Sex and Survival: Reproduction and Anti-Microbial Defense in the Red-Sided Garter Snake (Thamnophis sirtalis parietalis)

Creator:: Blakemore, Leslie A.
Abstract:: The red-sided garter snakes (Thamnophis sirtalis parietalis) of Manitoba, Canada, have been extensively studied for decades with little investigation into their immune system. These animals live very close to the arctic circle and spend over half of the year underground brumating. The annual cycle of the red-sided garter snakes make...
Resource Type:: Masters Thesis
Full Text:: reproduction and some components of innate immunity in ectothermic vertebrates. To investigate this potential

Hidden dynamics : community ecology and costs of parasite infection in African buffalo (Syncerus caffer)

Creator:: Henrichs, Brian
Abstract:: Most wild animals are concurrently infected with multiple parasite species for most of their lives. These parasite species assemble into rich and diverse communities, with parasites using host tissues for growth and reproduction as well as evolving strategies to evade the host immune system. The net effect of these ecological...
Resource Type:: Masters Thesis
Full Text:: infections are competitive interactions with similar parasites and not host immunity or genetic factors

Identification of novel immune molecular pathways and response markers to OmniGen-AF® supplementation in a rat model

Creator:: Branson, Jennifer A.
Abstract:: OmniGen-AF® (OG; Prince Agri Products, Inc., Quincy, IL) is a feed additive containing brewers dehydrated yeast and B-vitamins that supports immune function in ruminant livestock. Targeted profiling of immune-associated genes in whole blood is an effective platform for identification of a) novel molecular pathways and b) immune response markers to...
Resource Type:: Masters Thesis
Full Text:: effects of the supplement on both innate and adaptive immunity could be measured by using RNA purified

Infectious diseases of the Felidae : parasite communities from miniature to massive

Creator:: Broughton, Heather M.
Abstract:: Direct anthropogenic stressors have caused drastic declines in wildlife populations over the past two centuries. In the face of these threats, spillover of infectious disease from domestic animals and livestock into wildlife, and novel interactions between parasites and pathogens within wildlife communities, have further suppressed already vulnerable populations. As management...
Resource Type:: Dissertation
Full Text:: lentivirus, feline immunodeficiency virus (FIV), for structuring host health, immunity, and coinfection

Establishing a Humanized Microbiota Mouse Model of CVID-Enteropathy

Creator:: You, Hyekyoung Hannah
Abstract:: Common variable immunodeficiency (CVID) is the most common primary immunodeficiency that is characterized by low immunoglobulin levels in the body. CVID is indicated by failure of b cell differentiation and decrease production of immunoglobulins such as IgG and at least one of IgA or IgM. CVID patients with enteropathy (E-CVID)...
Resource Type:: Masters Thesis
Full Text:: ). When an inflammatory environment is created by the innate response, adaptive immunity responds by

Activation of Co-stimulatory Molecule OX40 Increases Memory T-cell Function and Cytokine Production in Uveitis

Creator:: Hall, Mark
Abstract:: Uveitis is a serious ophthalmological disorder characterized by intraocular infiltration of inflammatory cells. In most cases, uveitis is derived from the adaptive immune response. More specifically, CD4+ T lymphocytes play an important role in the pathogenesis of uveitis by recognizing uveitogenic antigen and orchestrating the immune response. While it is...
Resource Type:: Honors College Thesis
Full Text:: immunity transference. We used DO11.10 strains of BALB/c background whose transgenic T cell receptor

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation

Creator:: Shepherd, David M.
Abstract:: The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
Resource Type:: Dissertation
Full Text:: -specific or not. Innate (or natural) immunity is dependent on a variety of effector mechanisms which are

Virulent Mycobacterium avium subspecies Hominissuis Subverts Macrophages during Early Stages of Infection

Creator:: Ndzeidze, Robert F.
Abstract:: Interference with the host post-translational mechanisms, such as protein phosphorylation, is a key strategy used by many intracellular bacterial pathogens to subvert host immune cell function. Virulent non-tuberculous Mycobacteria (NTMs) unlike attenuated or non-pathogenic NTMs, successfully reside and multiply within the phagosomes of phagocytic cells such as monocytes and macrophages....
Resource Type:: Masters Thesis
Full Text:: very important role in the innate clearance of intracellular pathogens including NTMs. Low virulence

Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

Creator:: Kim, Jeonghwan
Abstract:: Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
Resource Type:: Dissertation
Full Text:: , their innate liver tropism significantly limits access to other organs, such as the lungs. Lungs are

Priming potato with thiamin to control potato virus Y

Creator:: Vinchesi, Amber C., Rondon, Silvia I., and Goyer, Aymeric
Abstract:: Potato virus Y (PVY) is a major potato pathogen affecting potato yields worldwide. Thiamin, a water-soluble B vitamin (vitamin B1) has been shown to boost the plant’s immunity, thereby increasing resistance against pathogens. In this study, we tested different concentrations of thiamin (1 mM, 10 mM, 50 mM, 100 mM)...
Resource Type:: Article
Full Text:: : 120-133. 330 Conrath, U. 2009. Priming of Induced Plant Defense Responses. In Plant Innate Immunity

Analysis of immune modulators in rainbow trout (Oncorhynchus mykiss)

Creator:: Mourich, Dan V.
Abstract:: The immune systems of various teleost fish have been studied in some detail for the past several decades. One aspect of fish immunity, that of endogenously produced modulating factors, has recently received a great deal of attention. Understanding the functions and roles of endogenous factors that regulate fish immunity is...
Resource Type:: Dissertation
Full Text:: for the past several decades. One aspect of fish immunity, that of endogenously produced

The effect of environmental chemicals on the tumor microenvironment

Creator:: Casey, Stephanie C., Vaccari, Monica, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Barcellos-Hoff, Mary Helen, Brown, Dustin G., Chapellier, Marion, Christopher, Joseph, Curran, Colleen S., Forte, Stefano, Hamid, Roslida A., Heneberg, Petr, Koch, Daniel C., Krishnakumar, P. K., Laconi, Ezio, Maguer-Satta, Veronique, Marongiu, Fabio, Memeo, Lorenzo, Mondello, Chiara, Raju, Jayadev, Roman, Jesse, Roy, Rabindra, Ryan, Elizabeth P., Ryeom, Sandra, Salem, Hosni K., Scovassi, A. Ivana, Singh, Neetu, Soucek, Laura, Vermeulen, Louis, Whitfield, Jonathan R., Woodrick, Jordan, Colacci, Annamaria, Bisson, William H., and Felsher, Dean W.
Abstract:: Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible carcinogens, the fields of endocrinology, genetics, epigenetics, medicine, environmental health, toxicology, pharmacology and oncology must be considered. Disruptive chemicals may also contribute to multiple stages of tumor development through effects...
Resource Type:: Article
Full Text:: that tumors develop and confront innate immunity. Many mechanisms may be involved in tissue

Clostridium difficile Spore-Macrophage Interactions: Spore Survival

Creator:: Paredes-Sabja, Daniel, Cofre-Araneda, Glenda, Brito-Silva, Christian, Pizarro-Guajardo, Marjorie, and Sarker, Mahfuzur R.
Abstract:: Background: Clostridium difficile is the main cause of nosocomial infections including antibiotic associated diarrhea, pseudomembranous colitis and toxic megacolon. During the course of Clostridium difficile infections (CDI), C. difficile undergoes sporulation and releases spores to the colonic environment. The elevated relapse rates of CDI suggest that C. difficile spores has...
Resource Type:: Article
Full Text:: evidence that C. difficile spores are well suited to survive the host’s innate immune system. Electron

From Microbes to Megafauna: The Ecology of Gut Microbiomes in Wild Herbivores

Creator:: Couch, Claire E.
Abstract:: All mammals host communities of commensal microbes in and on their bodies. Recent technological advances, combined with experimental studies in laboratory animals, are beginning to reveal the ubiquitous links between the gut microbiome and host disease, metabolism, immunity, and numerous other host functions. A new challenge of microbiome research is...
Resource Type:: Dissertation
Full Text:: between the gut microbiome and host disease, metabolism, immunity, and numerous other host functions

Disease invasion dynamics : brucellosis and tuberculosis in African buffalo (Syncerus caffer)

Creator:: Gorsich, Erin E.
Abstract:: Emerging infectious diseases in wild animals threaten global biodiversity as well as domestic animal and human health. Their unprecedented increase in conjunction with anthropogenically induced range shifts of endemic pathogens exposes hosts to novel parasite combinations, lending urgency to research on disease dynamics in wildlife systems. In natural populations, hosts...
Resource Type:: Dissertation
Full Text:: bovine tuberculosis (bTB), alters host immunity, infection patterns, fitness costs, and the dynamics of

Effects of Selenium Supplementation During Different Trimesters of Pregnancy on Total and Vibrio coralliilyticus Specific IgM Antibody Concentrations in Beef Cows at Parturition

Creator:: Zurita Cruz, Cindy
Abstract:: Background: The immune response to microbial infections is compromised in beef cattle at parturition. Innate and adaptive immunoglobulin M (IgM) serve as initial antibodies during microbial infection before the generation of adaptive immunoglobulin G (IgG). Selenium (Se) is an essential micronutrient required by all mammals, which can improve immune responses...
Resource Type:: Undergraduate Thesis
Full Text:: beef cattle at parturition. Innate and adaptive immunoglobulin M (IgM) serve as initial antibodies

Host Susceptibility Is Altered by Light Intensity After Exposure to Parasites

Creator:: Steinauer, Michelle L. and Bonner, Kaitlin M.
Abstract:: Translating research advances to natural systems using experimental laboratory studies is often difficult because of the variability between the natural environment and experimental conditions. Because environmental conditions have a large effect on an organism's physiology, responses to stressors like nutrient limitation, temperature, oxygen deprivation, predation, and parasite/pathogen infection are likely...
Resource Type:: Article
Full Text:: Comparative Endocrinology 163: 70–76. MYDLARZ, L. D., L. E. JONES, AND C. D. HARVELL. 2006. Innate immunity

Simultaneous Host-Pathogen Transcriptome Analysis during Granulibacter bethesdensis Infection of Neutrophils from Healthy Subjects and Patients with Chronic Granulomatous Disease

Creator:: Greenberg, David E., Sturdevant, Daniel E., Marshall-Batty, Kimberly R., Chu, Jessica, Pettinato, Anthony M., Virtaneva, Kimmo, Lane, John, Geller, Bruce L., Porcella, Stephen F., Gallin, John I., Holland, Steven M., and Zarember, Kol A.
Abstract:: Polymorphonuclear leukocytes (PMN) from patients with chronic granulomatous disease (CGD) fail to produce microbicidal concentrations of reactive oxygen species (ROS) due to mutations in NOX2. Patients with CGD suffer from severe, life-threatening infections and inflammatory complications. Granulibacter bethesdensis is an emerging Gram-negative pathogen in CGD that resists killing by PMN...
Resource Type:: Article
Full Text:: . Infection and Immunity, 83(11), 4277-4292. doi:10.1128/IAI.00778-15 10.1128/IAI.00778-15 American Society

Management Strategies to Improve Immune Function and Performance of Feeder Cattle

Creator:: Lippolis, Katana D.
Abstract:: Three experiments evaluated the effects of different management strategies on immune function and performance of feeder cattle. The objective of experiment 1 was to compare the effects of anticipating, delaying, or vaccinating against Bovine Respiratory Disease (BRD) at the time of weaning and feedlot entry on growth, DMI, and plasma...
Resource Type:: Dissertation
Full Text:: inorganic or organic complexed sources, during a 45-day preconditioning program on productive, immunity

Essential fatty acids and early life programming in meat-type birds

Creator:: Cherian, G.
Abstract:: Egg fat is of considerable importance in the nutrition of the developing chick as a source of energy and essential fatty acids such as linoleic (18:2 n-6) and α-linolenic (18:3 n-3) acids. During incubation, yolk lipids provide fatty acids that are utilized for energy, synthesis of polyunsaturated fatty acids (PUFA)-rich...
Resource Type:: Article
Full Text:: , (3) reduced production of pro-inflammatory eicosanoids, (4) suppression of cell- mediated immunity

ConnollyLanelleBiochemistryBiophysicsEpigeneticControlEffector.pdf

Creator:: Soyer, Jessica L., El Ghalid, Mennat, Glaser, Nicolas, Connolly, Lanelle R., Freitag, Michael, and et al.
Abstract:: Plant pathogens secrete an arsenal of small secreted proteins (SSPs) acting as effectors that modulate host immunity to facilitate infection. SSP-encoding genes are often located in particular genomic environments and show waves of concerted expression at diverse stages of plant infection. To date, little is known about the regulation of...
Full Text:: , pathogenicity determi- nants that modulate plant innate immunity and enable parasitic infection [1]. Effectors

Modulation of respiratory burst activity of trout (Oncorhynchus mykiss) phagocytic cells

Creator:: Galvan, Irja S.
Abstract:: In a comparison of the mammalian and fish immune systems many similarities and differences are found. While most of the differences occur in the acquired or lymphoid arm of immunity, the nonlymphoid immune systems of fish and mammals share many similarities. For instance, both animal groups use phagocytic neutrophils and...
Resource Type:: Dissertation
Full Text:: those of Mammals. 1 INTRODUCTION 1 IMMUNE SYSTEM TISSUES 1 ACQUIRED AND INNATE IMMUNITY 4 PHAGOCYTIC

Metabolic and Immune Responses in Cnidarian-Symbiodiniaceae Symbiosis and Dysbiosis

Creator:: Sawiccy, Valeri
Abstract:: Coral reefs, found in tropical regions, are renowned for their rich biodiversity and their contributions to ecological, cultural, and economic aspects worldwide. The success of coral reefs hinges on the symbiotic partnership between corals and their dinoflagellate algae, from the family Symbiodiniaceae. The algae reside within the coral host’s gastrodermal...
Resource Type:: Dissertation
Full Text:: understanding and emphasize the pivotal roles of metabolism and immunity in governing the success of coral

A Putative PAMP-Induced Peptide Family Member is Associated with Symptom Severity to the Necrotic Strain NTN of Potato Virus Y in Potato

Creator:: Combest, Max M.
Abstract:: Potato Virus Y (PVY) is an enduring problem for potato production worldwide. Potato varieties that resist the “ordinary” strain PVYO were developed by breeders, but in recent years, recombinant strains of PVY have been able to circumvent this strain-specific resistance and evade growers and seed certification officials by causing fewer...
Resource Type:: Masters Thesis
Full Text:: PAMP-Triggered Immunity pathway. activation of plant defenses in StPIP1-overexpressing plants was

1) Improving the Uptake and Retention of Gadolinium in Tumors for Potential Gadolinium-Neutron Capture Therapy. 2) Integration of Gemcitabine or Localized Irradiation into dsRNA Therapy Significantly Enhanced the Resultant Anti-tumor Activity

Creator:: Le, Uyen Minh
Abstract:: Cancer is one of the leading causes of death in the U.S., and new approaches to control cancer are constantly sought. This dissertation is comprised of two parts: (i) improving the uptake and retention of gadolinium in tumors for potential gadoliniumneutron capture therapy (Gd-NCT) and (ii) integration of gemcitabine or...
Resource Type:: Dissertation
Full Text:: immunogenic tumors, indicating that the T cell-mediated immunity was responsible for the synergy. The type I

Adaptive diversity and divergence at frog antimicrobial peptide loci

Creator:: Tennessen, Jacob A.
Abstract:: In this dissertation I study evolutionary patterns at genes encoding antimicrobial peptides (AMPs) in frogs. AMPs are short, amphipathic, cationic, secreted proteins that kill bacteria and other pathogens through a non-catalytic mechanism that involves binding to and disrupting the microbial cell membrane. In many animal taxa, positive selection is much...
Resource Type:: Dissertation
Full Text:: studies on other immunity genes. My research, which consists of both bioinformatic analyses of

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