Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes 2 the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. 3 One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active 4 site, but quantum mechanical calculations have been used...
Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes 2 the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. 3 One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active 4 site, but quantum mechanical calculations have been used...
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the Berkeley Center for Structural Biology supported in part by the National Institutes of
Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes 2 the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. 3 One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active 4 site, but quantum mechanical calculations have been used...
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is weaker than that of the Cys93 Sγ, consistent with the iron having 5
decreased occupancy. We
There is increasing evidence that aging is affected by biological (circadian) clocks – the internal mechanisms that coordinate daily changes in gene expression, physiological functions and behavior with external day/night cycles. Recent data suggest that disruption of the mammalian circadian clock results in accelerated aging and increased age‐related pathologies such...
A mixed initial and boundary value problem is considered for
a partial differential equation of the form Muₜ(x, t)+Lu(x, t)=0,
where M and L are elliptic differential operators of orders 2 m
and 2l, respectively, with m ≤ l. The existence and uniqueness
of a strong solution of this equation...
The history of entomopathogenic nematology is briefly reviewed. Topic selections include early descriptions of members
of Steinernema and Heterorhabditis, how only morphology was originally used to distinguish between the species; descriptions of the
symbiotic bacteria and elucidating their role in the nematode- insect complex, including antibiotic properties, phase variants, and...
Quantitative literacy is essential to biological literacy (and is one of the core concepts in Vision and Change in Undergraduate Biology Education: A Call to Action; AAAS 2009). Building quantitative literacy is a challenging endeavor for biology instructors. Integrating mathematical skills into biological investigations can help build quantitative literacy. In...
In 1959 the British Ornithological journal, The Ibis, published a centenary commemorative volume on the history of ornithology in Britain. Over the previous few decades, the contributors to this volume had helped focus the attention of ornithologists on the methods, priorities, and problems of modem biology, specifically the theory ofevolution...
Importance sampling algorithms are discussed in detail, with an emphasis on implicit sampling, and applied to data assimilation via particle filters. Implicit sampling makes it possible to use the data to find high-probability samples at relatively low cost, making the assimilation more efficient. A new analysis of the feasibility of...
In this paper we extend the results of the research started by the first author in which Karlin-McGregor diagonalization of certain reversible Markov chains over countably infinite general state spaces by orthogonal polynomials was used to estimate the rate of convergence to a stationary distribution. We use a method of...
The convolution inequality h ∗ h(ξ) ≤ B|ξ|θh(ξ) defined on Rⁿ
arises from a probabilistic representation of solutions of the n-dimensional
Navier-Stokes equations, n ≥ 2. Using a chaining argument, we establish
in all dimensions n ≥ 1 the nonexistence of strictly positive fully supported
solutions of this inequality for...
The efficacy of DNA extraction protocols can be highly dependent upon both the type of sample being investigated and the types of downstream
analyses performed. Considering that the use of new bacterial community analysis techniques (e.g., microbiomics, metagenomics) is becoming
more prevalent in the agricultural and environmental sciences and many...
This article concerns a systemic manifestation of small scale interfacial heterogeneities in large scale quantities of interest to a variety of diverse applications spanning the earth, biological and ecological sciences. Beginning with formulations in terms of partial differential equations governing the conservative, advective-dispersive transport of mass concentrations in divergence form,...
The purpose of this note is to provide a coupling of weak limits in distribution of sequence of (normalized) multiplicative cascade measures under strong disorder in terms of the extremes of an associated branching random walk, assuming i.i.d positive, non-lattice bond weights and a second moment condition. The solution is...
Advective skew dispersion is a natural Markov process defined ned
by a di ffusion with drift across an interface of jump discontinuity in
a piecewise constant diff usion coeffcient. In the absence of drift this
process may be represented as a function of -skew Brownian motion
for a uniquely determined...
The surgery technique of Gromov and Lawson may be used to construct families of positive scalar curvature metrics which are parameterised by Morse functions. This has played an important role in the study of the space of metrics of positive scalar curvature on a smooth manifold and its corresponding moduli...
For each Cantor set C in R³, all points of which have bounded local genus, we show that there are infinitely many inequivalent Cantor sets in R³ with the complement having the same fundamental group as the complement of C. This answers a question from Open Problems in Topology and...
RNA silencing is an evolutionarily conserved system that
functions as an antiviral mechanism in higher plants and
insects. To counteract RNA silencing, viruses express
silencing suppressors that interfere with both siRNA- and
microRNA-guided silencing pathways. We used comparative
in vitro and in vivo approaches to analyse the molecular
mechanism of...
Csanady (1998) presents solutions for time-dependent wind-driven flow in a barotropic
coastal ocean. We disagree with two of his three boundary condition options and wish to
clarify the origin of the non-wavelike aspect of the flow
Given two rational maps φ and ψ on Ρ¹ of degree at least two, we study a symmetric, nonnegative real-valued pairing〈φ, ψ〉which is closely related to the canonical height functions hφ and hψ associated to these maps. Our main results show a strong connection between the value of〈φ, ψ〉and the...
Three general types of swimbladders were found in the eight species of myctophids studied: gas-filled, fat-invested, and atrophied or reduced. Small specimens of all species had thin-walled, gas-filled swimbladders. Large specimens of Stenobrachius leucopsarus had fat-invested swim-bladders and large Diaphus theta had either gas-filled or atrophied swimbladders, as found by...
It is unlikely all male sage-grouse are detected during lek counts, which could complicate the use of lek counts as an index to population abundance. Understanding factors that influence detection probabilities will allow managers to more accurately estimate the number of males present on leks. We fitted 410 males with...
Diet variation among individuals within populations is widespread. Often diet differences among individuals are attributable to obvious differences among individuals such as age, sex, or morphology. However, growing evidence suggests that individual diet variation is also common among seemingly identical individuals within populations. This phenomenon has been termed individual diet...
For every finitely generated abelian group G, we construct an irreducible
open 3-manifold M[subscript G] whose end set is homeomorphic to a Cantor set and
whose homogeneity group is isomorphic to G. The end homogeneity group
is the group of self-homeomorphisms of the end set that extend to homeomorphisms
of...
Let X and Y be a pair of smooth manifolds, each obtainable
from the other by surgery in codimension at least three. We show that the
corresponding spaces Riem⁺(X) and Riem⁺(Y), respectively consisting of
Riemannian metrics of positive scalar curvature on X and Y, are homotopy
equivalent. This result is...
Extensions of the fractional Brownian fields are constructed over
a complete Riemannian manifold. This construction is carried out for the full
range of the Hurst parameter α ∈ (0, 1). In particular, we establish existence,
distributional scaling (self-similiarity), stationarity of the increments, and almost
sure H¨older continuity of sample paths....
Average annual losses caused by geologic hazards in Oregon are difficult to determine, owing to incomplete and scattered data. Preliminary considerations, however, indicate that losses to landslides may total between $4 million and $40 million per year. As many as nine persons have been killed by one landslide in Oregon...
One of the most beautiful and geologically interesting parts of the Oregon coast is in the vicinity of Cape Arago near Charleston, 10 miles west of Coos Bay. Three very fine state parks have been developed here. They are (from north to south): Sunset Bay, Shore Acres, and Cape Arago...
We consider solutions to the two-dimensional incompressible Navier-Stokes and Euler equations for which velocity and vorticity are bounded in the plane. We show that for every T > 0, the Navier-Stokes velocity converges in L∞([0,T]; L∞(R²)) as viscosity approaches 0 to the Euler velocity generated from the same initial data....
The geology of Oregon has become a jigsaw puzzle of moving parts set on a foundation of changing conditions as the crust and mantle undergo successively different manners of deformation through time. As more megahypotheses arise from increasingly sophisticated views of plate tectonics and from more detailed analyses of synoptic...
We examined terrestrial amphibians in managed headwater forest stands in western Oregon from 1998 to 2009. We assessed: (1) temporal and spatial patterns of species capture rates, and movement patterns with distance from streams and forest management treatments of alternative riparian buffer widths and upland thinning; (2) species survival and...
What do you say when you have only a minute to explain to a municipal official why keeping track of the number of bird species found in a park may help make decisions about park management? Talk of significant differences among treatments or testing theory will likely meet with glazed...