Alzheimer’s Disease (AD) is an abnormal part of aging that mainly affects those over the age of 65. The current therapies are only FDA approved for mild to moderate AD symptoms. Cannabidiol (CBD) is a non-intoxicating constituent of Cannabis sativa that has been shown to have beneficial effects on cancer,...
The internationalization brought about by online finding aids and the United States’ expanding diverse population necessitates a renewed focus on representation and accessibility in archival research. The accessibility of archival resources depends on the language in which the content is offered to the public. Throughout the United States, the Spanish-speaking...
Given the recent attention to dams in developing countries as a means to efficiently utilize water resources, mitigating the negative environmental and social impacts they have on riparian states is of utmost importance. This thesis presents a global review of how basin countries, through international water treaties (IWT), ensure that...
Motion planning is a cornerstone of autonomous robots, enabling robots to safely and efficiently perform tasks such as package delivery, infrastructure inspection, and manipulation. However, as the field of robotics matures, robotic systems are being developed that (1) are challenging to analytically model, (2) require computationally expensive model-based controllers, and...
Emotional understanding is important for social connection and fulfilling relationships across the lifespan. Without these skills, relationships with others can feel chaotic, unpredictable, and unattainable, affecting a person’s health and well being. Early childhood is a critical time to learn and practice foundational emotional skills that build into skills needed...
Understanding the magnitude and longevity of wildfire effects in forested watersheds and subsequent impacts to downstream aquatic ecosystems and communities requires congruent investigation into post-fire aquatic and terrestrial processes. However, results from wildfire studies are often confounded by pre- and post-fire land management actions and based on either hydrologic or...
Metabolomics has recently gained momentum in biomolecule research and complements the genomics and proteomics research space. Metabolomics strives to detect, identify, and quantify all metabolites present in biological samples. In particular, biomolecular analysis using ultra-performance liquid chromatography combined with mass spectrometry (UPLC-MS) has become increasingly important for metabolomic analyses. Similarly,...
Harmful algal blooms (HABs) are a problem for coastal communities, the fishing industry, and coastal organisms. Pseudo-nitzschia spp. is a regularly occurring diatom in Oregon’s coastal waters. At times, Pseudo-nitzschia spp. can facultatively produce domoic acid, a neurotoxin that can bioaccumulate in the food chain. While regular shore-based sampling provides...
The utility of high-throughput, computational screening has become an invaluable asset to the field of materials science. In the hierarchy of computational methods, the most accurate methods are often the most computationally expensive. However, as both the efficiency and fidelity of numerical techniques advance, high-quality screening of large materials datasets...
The gut microbiome has been previously implemented in a number of diseases. Of note is its substantial role in metabolic syndrome, which encapsulates a group of conditions that increase the risk of cardiovascular disease, type 2 diabetes, and stroke. Understanding the causal relationships between the gut microbiome and host processes...
Estimating how large instream wood (LW) may impact local hydraulics is critical both for mitigating flood hazards and for ensuring intended habitat benefits of the LW are produced. In practice, the design of forms such as LW is limited by a lack of mechanistic tools for estimating how LW features...
Estimating how large instream wood (LW) may impact local hydraulics is critical both for mitigating flood hazards and for ensuring intended habitat benefits of the LW are produced. In practice, the design of forms such as LW is limited by a lack of mechanistic tools for estimating how LW features...
Resilient interdependent critical infrastructures (CIs) can better withstand cascading failures in disruptive events. This study proposes network expansion as a resilience improvement strategy for interdependent CIs and evaluates the influence of topology in interdependent network design for resilience optimization under disruption uncertainty. A resilience score consisting of network complexity and...
Mechanisms of aging and age-related diseases are not completely understood in humans. Studying model organisms like Drosophila melanogaster, also known as the common fruit fly, can help humans better understand the aging process and diseases related to aging. From previous studies demonstrated in Drosophila, an accelerated aging model has been...
Rhizopus microsporus is a globally ubiquitous opportunistic human and plant pathogen that is known to harbor endosymbiotic bacteria. Differences between populations of clinical and environmental R. microsporus isolates have yet to be assessed on a global scale. Whole-genome sequence data were used to explore fungal biology and to assess potential...
Emerging research shows that individual differences in how people use technology sometimes cluster by socioeconomic status (SES) and that when technology is not socioeconomically inclusive, low-SES individuals may abandon it. To understand how to improve technology’s SES-inclusivity, we present a multi-phase case study on SocioEconomicMag (SESMag), an emerging inspection method...
Seaweeds have gained tremendous recognition as a highly nutritious and sustainable crop. The diverse components of seaweeds are known to exhibit a wide range of bioactivities, including anti-inflammatory, anti-diabetic, and cardiovascular health benefits. One such promising seaweed is Pacific dulse (Devaleraea mollis). While it holds great cultivating potential on the...
Smoldering combustion in wildland fires is difficult to extinguish, can transition to flaming combustion, and produces a significant amount of pollutants. It is necessary to understand parameters controlling smoldering in order to help predict the smoldering behavior and potentially mitigate these hazards. The wide variety of natural fuels that occur...
In the ever-evolving field of computer science (CS) education, the significance of teachers and their backgrounds have often been overshadowed by the predominant focus on students. Teachers in the K-12 often lack the necessary expertise and have limited support provided by existing CS-based curricula. While research on CS education effectiveness...
Global annual average temperatures are rising, creating extreme heat events or heatwaves that are increasing in frequency, length, and severity. The world will endure more of these events as climate change worsens and heat-related mortality and morbidity will increase due to warming conditions. At the center of heatwaves are urban...
In recent decades, the occurrence of large, high severity wildfires has increased substantially in many parts of the world, including the western United States. These fires have the potential to impact water quality, aquatic ecosystems, and downstream communities for many decades. As such, it is increasingly important to understand the...
Wildfire management networks allow for collaborative intervention in mitigating the ever-present risk of major wildfire events. This thesis consists of two manuscripts that explore the topology and characteristics of wildfire management networks and their ability to influence wildfire severity in social-ecological systems. The first manuscript focuses on the characteristics of...
Blue light exposure has been on the rise over the past several years as artificial light in the form of light emitting diodes (LEDs) have been increasing. These LEDs emit predominantly blue light through TVs, computer monitors, smartphones, tablets etc. Previous research in our lab determined that blue light accelerated...
Skeletal muscle mitochondria are highly plastic organelles, integral to whole-body health. High-fat diet (HFD) and exercise remodel the skeletal muscle mitochondria. Whereby, altered skeletal muscle mitochondrial function is linked to decreased skeletal muscle insulin sensitivity which can be reversed by exercise. However, the mechanisms that contribute to skeletal muscle remodeling...
Immune-mediated diseases are a frequent cause of morbidity and mortality in canine patients. Treatments currently involve generalized suppression of the immune system, and corticosteroids are often used as a first-line agent. While often effective, corticosteroids are unlikely to induce remission without substantial side effects. Second-line immunosuppressive agents may be effective...
In 2022, the Report Card on Physical Activity for Children and Youth noted only 24% of children ages 6 to 17 years achieved the recommended 60 minutes of physical activity daily, with a drop in physical activity as children age (Barriss, 2022). More importantly, children with disabilities have been found...
Grasslands in the Pacific Northwest are characterized by seasonally wet, acidic soils that mainly support cool season grasses and a limited number of legume species. A major limitation to efficient animal production in grass-dominant pastures is the decline in the herbage growth rate and nutritional quality of forage from late...
Power can be defined as the ability to influence the processes, decisions, and outcomes of an activity in favor of the will of a strong actor and its allies. Strategic actions in situations where there is asymmetric power can change the result of decisions. In this research, I will examine...
The focus of this thesis is to design, characterize, and apply novel computational methods and molecular systems to interrogate heterogeneous human gut microbiome-related phenomena. In Chapter 2, I design, implement, and characterize a method for embedding co-occurrence patterns derived from massive 16s amplicon datasets. I use this method to 1....
Learning latent space representations of high-dimensional world states has been at the core of recent rapid growth in reinforcement learning(RL). At the same time, RL algo- rithms have suffered from ignored uncertainties in the predicted estimates of model-free or model-based methods. In our work, we investigate both of these aspects...
Irradiation experiments are a critical aspect of the nuclear fuels and materials qualification process. Determining the flow conditions of these experiments is necessary for understanding response of nuclear components during transient and normal operation. Quality flow data is lacking for cartridge-type irradiation experiments with annular flow natural circulation designs. Data...
This dissertation presents novel, field-activated smart material systems for the actuation and control of autonomous robots. Smart materials, a type of material whose properties can be changed with an external stimuli, represent a promising direction to expand upon existing robotic control and actuation methods, particularly in the sub-fields of soft...
Transformation is a major bottleneck for genetic engineering and gene editing in forest tree species. This includes most genotypes of Populus and Eucalyptus, which are some of the world’s most widely-cultivated genera of plantation forest trees. To provide new tools for transformation, I tested the transcription factor-protein chimera consisting of...
As e-commerce and urban deliveries spike, there is an increasing demand for curbside loading/unloading space. However, commercial vehicle drivers face numerous challenges while navigating dense urban road networks. Previous literature on the topic of how commercial vehicle drivers make choices about when and where to park is scarce, and data...
Engineering education research has led to a greater understanding of the gap in preparedness of students for the engineering industry. Multiple studies comparing the workplace and academic contexts and the participants in those contexts (i.e., students, faculty, and engineering practitioners) have emphasized similarities and differences between the two contexts by...
In this thesis, a new learning algorithm is introduced that is targeted towards individual fairness. In order to be individually fair, mispredictions need to be avoided as each such prediction means the learning algorithm was unfair towards some individual. Therefore, achieving individual fairness implies having a perfect classifier, which is...
Laser Powder Bed Fusion (LPBF) is a process commonly used to create additively manufactured metal parts. The flexibility and complexity allowed by the LPBF process provides opportunity for significant advancement in multiple industries as parts can be customized in shape and function for specific needs. These benefits can be compounded...
Throughout their lifetime individuals are exposed to complex mixtures of chemicals. The study of chemical mixtures is an internationally recognized research priority, but seemingly complex challenge. To reduce the intricacy of studying mixtures, researchers have identified different prioritization methods based on exposure or the toxicity of chemicals. However, understanding the...
Structural engineered wood manufacturers need a quantitative measurement technique to determine the ratio of wood to adhesive failure in their shear specimens. Visual estimation of percent wood failure has long stood as an extremely subjective quality control approach according to ASTM D5266 – Standard Practice for Estimating the Percentage of...
Skeletal muscles provide several functions, including, yet not limited to, voluntary body movement and locomotion, posture and body position, and soft tissue support. Skeletal muscles also play a role in metabolism, requiring energy to facilitate contraction. Each skeletal muscle serves a different purpose despite seeming to perform the same task....
Submerged aquatic vegetation (SAV) species, such as seagrasses, are highly valued in estuaries because of the many economic, ecological, and cultural services that they provide, including shelter for fisheries, minimizing water turbidity, and improving am-bient water quality. SAV can also alter its physical environment by attenuating wave and current velocities,...
Systems biology is a powerful approach which considers and sheds light on all of the puzzle pieces which make up complex biological processes, and is an effective alternative to unraveling these processes using traditional molecular approaches alone. It is a natural companion approach for computational biology, which leverages the power...
Hydrological and biogeochemical processes occurring throughout a watershed are typically reflected in stream water chemistry, including in coastal watersheds. While Oregon Coast Range streams have been studied in the past, there is a dearth of knowledge in terms of seasonal temporal trends and spatial variability that this study seeks to...
With Alzheimer’s disease being the most prominent form of dementia, finding potential treatments for the disease is imperative. This study explored the non-steroidal anti-inflammatory drug ibuprofen as a potential treatment to normalize the hyperactive N-methyl-d-aspartate receptor (NMDAR) within the 5xFAD mice early in the disease pathology before cognitive decline. Female...
Despite the prominence of LEDs in our society, we have limited knowledge pertaining to their long-term effects. These seemingly white LEDs have a large blue light component to them. Recent results have shown that Drosophila living in 12 hrs. of blue light and 12 hrs. of darkness live substantially shorter...
Early childhood is a crucial time for the holistic development of a child’s social, emotional, cognitive, and physical needs to build a solid and broad foundation for lifelong wellbeing and learning (Irwin et al., 2007). During this critical period, there is an increased demand for motor skills and executive function...
The Vietnamese population that migrated to the United States is largely tied to South Vietnam. As the population settled, their strong opposition to communism has driven many in the community towards political alignment with the alt-right and even white nationalists. The proximity to these movements and their seeming tolerance of...
We do not know how to align a very intelligent AI agent's behavior with human interests. I investigate whether—absent a full solution to this AI alignment problem—we can build smart {\ai} agents which have limited impact on the world, and which do not autonomously seek power. In this thesis, I...
About one third of Americans have metabolic syndrome, which is characterized by five risk factors related to blood pressure and triglyceride levels and could lead to diabetes and heart disease if left untreated. Watermelon has been shown to exhibit cardioprotective effects due to its high phytochemical content and may act...
The majority of people suffer from back pain at some point in their lives. Back pain is the leading cause of disability globally, ahead of 290 other conditions1. Over one million people in the United States receive spine surgery annually2. This thesis looked at five standard surgical procedures performed on...