Ceratonova shasta is an obligate endoparasite of salmonid fish that is endemic to the Pacific Northwest of North America. The parasite has a complicated lifecycle with two distinct spore stages and two obligate hosts, a salmonid and a freshwater annelid. Myxospores released from infected salmonid hosts, infect Manayunkia occidentalis (freshwater...
Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
The use of ethionamide has been increasing in drug regiments due to greater incidence of multidrug resistance tuberculosis around the world. Ethionamide is metabolized into antimicrobial relevant compounds by different flavin-containing monooxygenase (FMO) enzymes including FMO1, FMO2, and FMO3. FMOs are found in various locations in the body including the...
Defining the inelastic behavior of nail joints is essential
in the development of a rational design procedure of wood-stud walls.
Prediction equations were developed for the inelastic behavior
of joints commonly found in wood-stud walls. The equations relate
three elastic moduli that define the average inelastic joint stiffness
to the...
Reported here is an investigation to determine the in vitro and in vivo metabolism
of xanthohumol (XN). XN is the major prenylated flavonoid of the female
inflorescences (cones) of the hop plant (Humulus lupulus). It is also a constituent of
beer, the major dietary source of prenylated flavonoids. Recent studies...
Nearly 80% of solid tumors, such as melanoma, metastasize via the lymphatic system. The most common form of melanoma is BRAF-mutant melanoma, and additional mutations, such as a PTEN mutation in the PI3K pathway, is required for metastases to occur. Standard therapy includes treatment with small molecules dabrafenib (DAB) and...
This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
The assessment of optimum nitrogen (N) fertilizer need for winter wheat (Triticum
aestivum L.) is important for economic and environmental sustainability. A comprehensive understanding of fertilizer N requirement depends on estimation of the quantity of N needed by the crop versus that supplied by soil.
The objectives of this study...
In a series of greenhouse experiments, isolates representing serotypically
distinct subpopulations of Rhizobium leguminosarum bv. trifolii recovered from root
nodules of field-grown subclover Trifolium subterraneum cv. "Nangeela"), were
evaluated for their symbiotic effectiveness potential, their effect on regrowth
potential of subclover, and for their competitive abilities to form nodules. Isolates...
During the course of ripening, Cheddar cheese frequently develops
a flavor defect described as fruity. Recent work has indicated
that the use of certain starter cultures ultimately results in the
development of the defect as the cheese ages. The flavor compounds
responsible for the defect, however, have not been elaborated....
This research focuses on the relationship between the emerging role of land trusts and
rapid growth and change in the West. Teton County, Idaho, Teton County, Wyoming, and
Sublette County, Wyoming, and each of their associated land trusts, are used as case studies. Each county has experienced varying levels of...
Despite advances in treatment, cancer remains among the leading causes of death in the world. Progress in the treatment of metastatic cancers was seen with chemotherapy and radiotherapy, however, the major drawbacks of conventional cancer therapies are limited efficacy and severe side effects. Magnetic fluid hyperthermia (MFH) is a new...
Numerous studies have explored how alluvial channel size and morphology are adjusted to different sediment and flow conditions, yet we still know very little about how and to what degree the flow regime controls channel form and processes. We use the term ‘channel form’ to refer to the size and...
This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...
Cancer is one of the leading causes of death in the U.S., and new approaches to control cancer are constantly sought. This dissertation is comprised of two parts: (i) improving the uptake and retention of gadolinium in tumors for potential gadoliniumneutron capture therapy (Gd-NCT) and (ii) integration of gemcitabine or...
This paper describes the design and implementation of
"A multiprocessor node for communication and control"
(MPCC). MPCC is a high speed, high performance local area
network capable of performing real time control tasks. This
is achieved by the concurrent operation of two 8051
microcontrollers, a dual port RAM and the...
A transient code (TFETC) for calculating the temperature
distribution throughout the radial and axial positions of a
thermionic fuel element (TFE) has been successfully developed.
It accommodates the variations of temperatures, thermal power,
electrical power, voltage, and current density throughout the
TFE as a function of time as well as...
Transparent conductive oxides (TCOs), primarily indium doped tin oxide, have been widely used in numerous fields since decades ago, such as solar cells, displays, OLEDs and ‘smart windows’ etc. Owing to the scarcity of indium, there is a great demand for new alternative materials. Metal/insulator/metal (MIM) diodes are a critical...
This paper is a summary of a larger project that consolidated
agricultural land use projection information for the Pacific Northwest,
as of January 1979. The characteristics of nine major projection studies
are identified and used as a basis for comparing the relative merits of
each study with regard to: 1)...
The effect of incorporated sawdust, sawdust mulch and nitrogen (N) fertilizer rate on soil nutrients and other properties, N uptake, and plant growth in a young blueberry planting on a silt loam soil type was studied in 2004 and 2005. ‘Elliott’ highbush blueberry plants were established on raised beds that...
Understanding the interplay between energy and water is central to effective natural resource management. With enough energy it is possible to secure sufficient water, with enough water it is possible to produce nearly boundless energy. The sun is the engine which drives the availability of both these resources; nearly every...
California and Steller sea lions (Zalophus californianus, Eumetopias jubatus, respectively) are considered sentinel species because they have long life spans, are long-term coastal residents, feed at high trophic levels, and have large blubber stores that serve as depots for anthropogenic toxicants. There are few studies on sea lion health and...
Managing agricultural diversity ensures a range of public services, such as genetic resource diversity, food security for subsistence-based economies, and landscape resilience in the context of climate change, among others. These agrobiodiversity conservation services are positive externalities from agrobiodiversity conservation. Whereas their value is not captured in market transactions, management...
PURPOSE: We tested the hypothesis that the unsupervised, isokinetic 3- minute all-out cycling test (3MT) would be a valid and reliable way to determine end power (EP) and work done above end power (WEP). Additionally, we hypothesized that EP would successfully demarcate between heavy and severe-intensity exercise and thus represent...
Resilience-based management in rangelands implies maintaining desirable ecological states and avoiding thresholds to less desirable ones; however, the efficacy of resilience-based management depends upon several driving forces. These forces include management by those who depend upon rangelands for their livelihoods, the current state of ecological health of rangelands, and changing...
:
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Heidi J. Albers John A. Tanaka
Resilience-based management in rangelands implies
The thermal degradation of structural materials is considered to be a key factor for evaluating the lifetime of current nuclear power plants. Ni-based and Fe-based alloys, such as 690, 625, 304, and 316, are widely used in nuclear industry as structural components due to the extraordinary corrosion resistance and mechanical...
American women’s quest for equality came into focus in the early 1900s. Amidst the cultural and societal forces pushing for suffrage, some chose the mechanism of theater. This thesis is a work of rhetorical criticism. It applies Lloyd Bitzer’s situational approach to two suffrage theater artifacts: Mary Shaw's The Woman...
The purpose of this thesis is to propose swiveling behavior as a potential speech transitioning device and to discuss the methodology behind qualitative and quantitative analysis of swivels in relation to subjects’ partners. Due to the impacts of gaze and body orientation direction on speech transitioning, it is deduced that,...
Foot pathology is a real problem in captive elephants. Osteoarthritis is the major concern among musculoskeletal disorders and foot health problems for elephants in North America zoos with one-‐half of Elephants in captivity showing foot health care problems in zoos. A higher ratio of captive Asian elephants (Elephas maximus) is...
Amorphous metal thin films lack the grain boundaries and dislocations present in
crystalline metal films. As a result, amorphous metal films can be more mechanically robust, atomically smooth, and more resistant to chemical attack than crystalline metals. However, amorphous metals are meta-stable and subject to crystallization upon heating, thus limiting...
Lycopodium alkaloids have shown widespread and noteworthy biological activity, consisting of over 250 known natural products. Moreover, their structural complexity and diversity have attracted considerable attention from numerous laboratories including our own. Recently, we have developed a unified approach that would provides access to numerous, previously unprepared C₁₀-functionalized lycopodium alkaloids....
A MOS biquadratic (biquad) filter employing the switched-current technique is
reported. The circuit uses current-mode processing which can offer wide
bandwidth, low voltage operation, and can be implemented with standard CMOS
technology. Examples of lowpass, highpass, and bandpass filters are given
which illustrate the synthesis procedures and the versatility of...
Seed yield in perennial ryegrass is the product of yield components
that develop during the life of the plant. Crop yield potential is
defined by the number of fertile tillers, spikelets per spike, and
florets per spikelet. It has been shown that perennial ryegrass
realizes only a small percentage of...
I tested a theoretical model proposing that anemia
favors transmission of blood-borne parasites to vectors
by accelerating the blood-feeding rate. Using Aedes
aegypti, the yellow fever mosquito, initially, I was not
able to confirm this phenomenon either in an artificial
or a live system; anemia did not correlate with blood-feeding...
Location is a critical component of business decisions. A firm's location decision may be influenced not only by market forces, such as the location of input suppliers, output processors and competitors, but also by government policies if such policies impact their expected profits and are applied non-uniformly across space. Likewise,...
This dissertation consists of three essays on private landowners' response to incentives for carbon sequestration in forests. The first essay examines private landowner response to incentives for carbon sequestration through various combinations of intermediate management practices. The second essay focuses on agricultural landowners' willingness to participate in an incentive program...
In this report, the optical characteristics of ZnS:Tb AC driven thin-film
electroluminescent devices are evaluated. Luminescence at low and room temperature
under a constant phosphor field is recorded in order to probe the hot electron energy
distribution. Samples fabricated by atomic layer epitaxy and by sputter deposition are
investigated and...
New transparent p- and n-type semiconductors and luminescent materials have been prepared and characterized. Synthesis, structures, optical and electrical properties of new chalcogenide fluoride p-type transparent semiconductors MCuQF (M=Ba, Sr; Q=S, Se, Te) are described. Band-gap tuning and improvement in conductivity through p-type doping are demonstrated in the family. The...
Highbush blueberry (Vaccinium corymbosum L.) is adapted to soils with high organic matter and acidic pH. Composts provide organic matter and nutrients for growing blueberry in mineral soils, but many composts are high in pH and soluble salts. Acidification with elemental sulfur (S°) can remedy high pH, but the process...
This dissertation outlines two approaches for improving the efficiency and reducing the cost of photovoltaic energy generation. First, the structures of known binary copper and iron compounds are used to choose the promising compositions Fe₂XS₄ (X = Si, Ge), Cu₃TaQ₄ (Q = Se, Te), and BaCuQ'F (Q' = S, Se,...
Detection technique that proposed utilizing electrochemically controlled, reversible ion extraction into polymeric membrane in an alternating galvanostatic/ potentiostatic mode was introduced. This method is studied in detail to comprehend the advantages of the novel sensor (pulstrode) compared to the potentiometric ion selective electrode (ISE), studies included possible applications and limitations....
The original research detailed in this document recognizes that the majority of students with disabilities between 18-69 years of age will attend a community college. The literature also indicates an exponential increase for better job opportunity and earnings relative to individuals with disabilities who attain higher levels of education. This...
The general emphasis of this work has been synthesis, characterization, and applications of n- and p-type inorganic oxide thin films that are deposited from solutions. In particular, a study of n-type transparent semiconductor films of tin (IV) oxide and zinc-doped tin (IV) oxide has been performed by spin coating. Solution...
The northern goshawk (Accipiter gentilis) is a species of concern in the western United States due to its association with mature structural stage forests. I employed a use-versus-availability study design to quantify the vegetative, physiographic, and landscape variables associated with goshawk breeding habitat selection in the San Juan Mountains of...
Childhood obesity prevalence is significantly higher among adolescent 12-19 years old than younger age groups. Youth athletes are overlooked by childhood obesity prevention programs. WAVE~Ripples for Change (WAVE) program is a 2-y obesity prevention intervention with high school (HS) soccer players (14-19y) using a mixed virtual- and physical-world learning environment...