Isomerically pure cis,cis,trans-1-pheny1-1,3,5-
heptatriene was prepared and cyclized. Ring closure
was followed by a 1,5 hydrogen shift, and the only product
observed was 1-phenyl -6-methyl -1,3-cyclohexadiene.
Rough first order rate constants for thermolysis and
the hydrogen shift were determined. Kinetic estimates
indicate that the report of disallowed product in a...
Part 1
The pyrolysis of cis-1-trimethylsiloxy-1-cyclopr opyl-3-cyclononene in the temperature range 285-350° is described. Instead
of siloxy-Cope rearrangement, undesired desiloxylation took place.
Part 2
Gas-phase pyrolytic rearrangement of 2-phenyl-1-trimethylsiloxy-1-vinylcyclononane was investigated in a static system
in the temperature range 213-330°. It was discovered that
three major products resulted: cis- and...
Both oxy-Cope and siloxy-Cope rearrangements involve
(1, 3) and (3, 3) sigrnatropic shifts. Both the concerted mechanism,
and the stepwise mechanism via a diradical intermediate are possible.
In a cyclic system such as cis-l-vinylcyclooct-3-en-l-ol, the thermal
rearrangement takes place preferably through a diradical intermediate.
At high temperature, the reaction also...
Certain 2- chioroethyl nitrosoureas have been demonstrated
to be highly specific inactivators of chymotrypsin
in vitro and glutathione reductase, both in vivo and in
isolated rat hepatocytes. The inactivation of glutathione
reductase in isolated hepatocytes resulted in an increased
sensitivity toward an adriamycin induced oxidative
challenge.
Prolonged incubation of 1-(2-chloroethyl)-3-([1-¹⁴...
This thesis examines the interconnection between the in vitro and in
vivo phosphorylation of rabbit muscle phosphofructokinase. The first goal
of the project was to show whether a novel site of rabbit muscle
phosphofructokinase that is subject to in vitro phosphorylation, serine 376,
may also become phosphorylated in vivo. Evidence...
The study and utilization of Danio rerio (Zebrafish) as a model organism has increased greatly in recent decades. They are used in many areas of biological research, but one field that has used them extensively is immunology. Since zebrafish have been found to possess many orthologs to human genes, study...
In two studies we tested the effect of vitamin B-6
(B-6) intake on in vitro lymphocyte, proliferation and IL-2
production in healthy young women. In Study I, 6 women were
fed a constant diet containing 0.84 mg (4.96 μmols) of B-6
for 12 d, and 1.24 mg (7.33 μmols) and...
One-electron oxidation of the μ-oxo dimer
(cis,cis-[Ruᴵᴵᴵ(bpy)₂(OH₂)]₂O⁴⁺, {3,3}) to {3,4} by S₂O₈²⁻ can
be described by three concurrent reaction pathways corresponding
to the three protic forms of {3,3}. Free energy
correlations of the rate constants, transient species dynamics
determined by pulse radiolysis, and medium and temperature
dependencies of the alkaline...
An evaluation was made in 21 seed production areas and 1 seed orchard in Region 1 to identify the primary insect pests and to assess amount of injury caused. Cones from Douglas-fir, grand fir, western larch, lodgepole pine, ponderosa pine, and western white pine were collected periodically and examined. The...
Insect damage was extensive to Douglas-fir, ponderosa pine, western white pine, and western larch cones at most seed production areas surveyed in 1979. From 70 to 100 percent of the cones from several collecting periods were injured. Moderate damage (40-70 percent of cones injured) occurred to Douglas-fir, ponderosa pine, western...
The OSU Perspective was developed to provide assessment and other information about our students and programs. We hope that by making this information available to OSU faculty and staff, we can stimulate conversation that helps to keep students and student learning at our core.
The Perspective is published quarterly both...
The OSU Perspective was developed to provide assessment and other information about our students and programs. We hope that by making this information available to OSU faculty and staff, we can stimulate conversation that helps to keep students and student learning at our core.
The Perspective is published quarterly both...
In endurance-trained men, an acute bout of exercise is shown to suppress post-exercise appetite and alter changes in specific appetite regulating hormones. Limited research has examined these responses in endurance-trained women. PURPOSE: To investigate the effect of exercise intensity on the appetite regulating hormones acylated ghrelin, PYY and GLP-1 and...
The spatial distribution and geologic histories of submarine volcanoes provide insight into submarine eruptive behavior, deep earth processes and plate tectonics. This dissertation examines the evolution of individual submarine volcanic edifices as well as linear trails of seamounts at three spatial and temporal scales.
In order to understand constructive and...
Two studies were conducted to determine the effect of varying vitamin B-6 (B- 6) status on lymphocyte mitogenic response and pyridoxal 5'-phosphate (PLP) concentration in peripheral blood mononuclear cells (PBMC) in young women. In the first study, women were fed 1 mg/d for the first week and 1.5, 2.1 and...
A foundation for the control of tumors is presented,
based upon the formulation of a realistic, knowledge-based
mathematical model of the interaction between tumor cells
and the immune system. The parametric control variables
relevant to the latest experimental data, e.g., the sigmoidal
dose-response relationship and Michaelis-Menten dynamics,
are also considered....
Background: Breast cancer is the most common cancer among women. In 2012, over 220,000 women were diagnosed with breast cancer in the United States. It has been hypothesized that dairy may play a role in breast cancer; however, the evidence has been inconsistent and limited. Proposed mechanisms linking dairy and...
Full Text:
Directions
RR (95% CI)
RR (95% CI)
RR (95% CI)
RR (95% CI)
P = <0.001)
P = <0.001)
Slide Number 1
Lead-free Bi(Mg₁/₂Ti₁/₂)O₃-(Bi₁/₂K₁/₂)TiO₃-(Bi₁/₂Na₁/₂)TiO₃ (BMT-BKT-BNT) ceramics have
been shown to exhibit large electromechanical strains under high electric fields along with
negligible fatigue under strong electric fields. To investigate the role of point defects on the
fatigue characteristics, the composition 5BMT-40BKT-55BNT was doped to incorporate acceptor and
donor defects on the A and...
Tenure has often been situated as a non-negotiable tenet of modern academia, a status granted after a probationary period and extensive review, and critical for academic freedom. However, the processes by which promotion and tenure (P&T) are vetted depart in practice from the meritocratic ideal that is frequently used to...
Continuous integration (CI) systems automate the compilation, building, and testing of software. Despite CI being one of the most widely used processes in software engineering, we do not know what motivates developers to use CI, and what barriers and unmet needs they face. Without such knowledge developers make easily avoidable...
By inverting EarthScope long-period magnetotelluric (MT) data from the southeastern United States (SEUS), we obtain electrical conductivity images that provides key insights into the geodynamics of this region. Significantly, we resolve a highly electrically resistive block that extends to mantle depths beneath the modern Piedmont and Coastal Plain physiographic provinces....
Neryl pyrophosphate, rather than geranyl pyrophosphate, is
believed to be the immediate biological precursor of the cyclohexanoid
monoterpenes because the cis-2, 3-double bond readily permits cyclization.
Biosynthesis of neryl pyrophosphate could occur by either of
two principal mechanisms: direct cis condensation of dimethylallyl
pyrophosphate with isopentenyl pyrophosphate or trans-cis isomerization...
Materials based on BiMO₃-modified BaTiO₃ have been shown to exhibit a number of attractive electrical and electromechanical properties. In addition, many of the materials in this broad family exhibit reduced sintering temperatures for densification as compared to pure BaTiO₃. We report here a study of the phase evolution and sintering...
Conversion of exogenous cis-zeatin to trans-zeatin in immature seeds of
Phaseolus vulgaris L. led to the isolation of a cis-trans isomerase from the endosperm.
The enzyme was purified over 2000-fold by chromatography on a series of FPLC
(anion exchange, gel filtration, and hydrophobic interaction) and Concanavalin A
columns. Non-enzymatic isomerization...
Continuous Improvement (CI) is an integral part of hospital administration. This study examined the relationship between five CI variables against six hospital criterion measures of, wait times to prepare a room, patient costs per day, waiting time for lab results, reportable errors, patient satisfaction, and employee satisfaction. The research was...
This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
Bovine viral diarrhea virus (BVDV) is an enveloped, single-stranded positive-sense RNA virus. The BVDV genome is about 12.5 kb long and consists of a single open reading frame (ORF) flanked by untranslated regions at the 5' and 3' ends (5'-UTR and 3'- UTR, respectively). To investigate the role of cis-sequences...
Coreplication experiments have revealed that replication of
turnip yellow mosaic virus (TYMV) RNA in turnip protoplasts is cis-preferential.
Genomes encoding mutant p141 or p66, proteins
essential for virus replication, were inefficiently rescued by a
helper genome. One model for the cis-preferential replication of
TYMV is that p66 and p141 form...
Tenure has often been situated as a non-negotiable tenet of modern academia, a status granted after a probationary period and extensive review, and critical for academic freedom. However, the processes by which promotion and tenure (P&T) are vetted depart in practice from the meritocratic ideal that is frequently used to...