Chemical equilibrium is a major factor in many natural and
industrial systems. The ability to predict ionic equilibrium is
extremely valuable in industry in solving problems without the costs
involved in full scale experiments. An example of an application in
the pulp and paper industry is the prediction of non-process...
This thesis describes evaluation of a novel self-sealing chewable sustained release tablet that can maintain controlled release of drug regardless of compaction, crushing, or chewing. The new formulation contains polyethylene oxide which produces a sealant effect for cracks produced in the polymer coating during compaction. Dissolution studies were conducted and...
The numerical modeling of motions in the atmosphere's
planetary boundary layer (PBL) is a challenging task. In
general, the boundary layer interacts with both the overlying
atmosphere and the underlying land or water surface
in a complex manner. Random turbulence is also present in
the PBL which precludes exact prediction...
In this research a model is developed to predict population for relatively
rural areas experiencing rapid economic development. Of the many
ways to predict population size, in this research a "demographic-economic"
model is chosen for use. The economic variables which aid in projecting
population are total employment, and net changes...
A satellite-derived Climatology of Global Ocean Winds (COGOW) on a 0.5° latitude by 0.5° latitude grid is presented based on 5-years (August 1999 July 2004) of measurements from the SeaWinds scatterometer that was launched on 19 June 1999 onboard the QuikSCAT satellite. SeaWinds is an active microwave radar that estimates...
The effects of possible operating variables such as flow rate, surface temperature, bulk temperature, solids contents, sulfate addition and pH on the fouling of sulfite spent evaporators were studied. The study pointed out that the Ca⁺⁺ concentration difference between heated surface and bulk is the most important factor for fouling...
The effect of concentration, vehicle and surfactant on the
absorption of benzocaine -³H across the rat's rectal mucosa was
investigated. Blood radioactivity levels were determined after the
application of benzociane -³H containing suppositories and ointments.
A wet oxidation method was used for sample digestion. Since the
radioactivity counted is the...
Vital rates and population connectivity are fundamental concepts in animal ecology and such information is critical for successful conservation planning. The Black-backed Woodpecker (Picoides arcticus) is a species of conservation concern because of its strong association with forests recently burned by high-severity wildfire. However, several recent studies have found that...
The infrared spectra of the metaborate monomer and trimer
ions in NaC1, KC1, and KBr were studied. These spectra contain
bands due to the trimer in solid solution, in a second phase of the appropriate
potassium or sodium salt, and perhaps on adjacent lattice
sites. Furthermore, complex equilibria exist between...
The forest products industry often uses intermediate-support cable logging systems to transport logs from the harvest site to a staging area. A method is presented to assist in the analysis and design of these cable systems. The method determines tensions in individual cables, forces on and stresses in the support...
Propionic acid, live Propionibacterium shermanii, and
Dimethyl Fumarate (DMF) were tested for their stimulatory or
inhibitory efects on yeast, bacteria, and molds. The amount
of propionic acid required for inhibition of molds was
strain specific and equal to or less than that required for
inhibition of the yeasts. Live P....
Improved assay methods for determination of dyphylline levels in plasma, saliva, and urine utilizing high pressure liquid chromatography have been developed. Detection of levels as low as 25 ng/ml from 0.5 ml plasma and 50 ng/ml from 0.5 ml saliva were possible. Both procedures utilized the same extraction process. A...
The current and potential benefits of using geographic information systems (GIS) to support state-level and regional-scale ocean management in the United States are evaluated. Specifically, the role of GIS in facilitating improved integration of management strategies for a variety of resource use issues across multiple management jurisdictions is examined, along...
Gastric retention time of single unit dosage forms in swine was found
to be much longer than in humans. It was concluded that swine are not a
good animal model to study GI transit time of nonerodable or slowly eroded
dosage forms. Noneradable and slowly eroded dosage forms used to...
The bioavailability and pharmacokinetics of theophylline
in rabbits were determined following both oral and
intravenous administration of the drug. Serum theophylline
concentrations were determined using high pressure
liquid chromatography. Pharmacokinetic parameters were
determined and verified by computer analysis. The overall
mean Beta disposition constant was 0.089 hr⁻¹ which corresponds
to...
This thesis describes a project to produce controlled release ketoprofen beads for capsules, both at Oregon State University and in an industrial scale-up operation, that are bioequivalent to the commercial product Oruvail. A bead formulation was produced by layering drug and binders in water onto nonpareil sugar seeds in a...
In vivo research following ingesting of commercially available
Lactobacillus tablets, which contain about 2X10⁶ cfu/tablet of
Lactobacillus acidophilus and Lactobacillus bulgaricus cells in a dose
of four tablets daily, showed serum lipoprotein concentrations did not
change significantly. In order to increase the number of viable
Lactobacillus bacteria after challenging in...
The role of iron in the body is well known for it is a component of hemoglobin, myoglobin, cytochrome, enzyme catalase and peroxidase. Iron deficiency anemia is widespread among vulnerable groups in industrialized societies and in the general population of tropical developing areas. In the United States there are ten...
Non-process elements are present in all kraft
recovery systems. Non-process elements are defined as
those elements which are not essential to the chemical
process, i.e., are neither active pulping chemicals (e.g.,
NaOH and Na₂S in the kraft process), nor compounds present
as a result of incomplete conversion of makeup chemicals...
This dissertation describes how to apply pharmacokinetic simulations and modeling in a clinical setting to monitor and adjust drug dosing in special patient populations. Pharmacokinetic simulations were used to investigate efficacy and risk of drug toxicity of a new dosing regimen for aminoglycoside antibiotics when administered to renal failure patients....
Future scenarios of global climate change rely on large-scale climate envelope models that do not account for local climatic conditions to which organisms most closely respond. Shifts in species distributions and phenology driven by climate change are well-documented, yet we lack a strong understanding of how climate change will influence...
Dyphylline is an analog of theophylline and the latter
is the most popular member of the methylxanthine family in
use for the treatment of asthma. Although dyphylline is
devoid of some problems associated with theophylline, a
reported short half-life has made it's clinical usefulness
limited. To avoid this problem a...
Snags provide critical habitat for nearly one-third of wildlife species in forests of the Pacific Northwest, so historic declines in snags are thought to have had a strong impact on biodiversity. Resource managers often create snags to mitigate the scarcity of snags within managed forests, but information regarding the function...
Black liquor recovery boilers experience significant fire-side fouling problems due to the deposition of entrained particulate matter. Increased understanding of the mechanisms by which particles deposit on these surfaces will lead to more effective management of the resultant problems. There is some evidence which suggests that the sub-micron fraction of...
The source and nature of permit value and the federal grazing fee debate motivated this dissertation research. There is little doubt that federal grazing permits have value throughout the western United States, but the source of permit value is unclear. A traditional explanation focuses on the capitalized differential between the...
This thesis describes 1) development of a gastric retention device (GRD) to
increase gastric retention time of certain drugs, 2) product formulations of an immediate
release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked
carbohydrate polymers. Rate and extent of hydration of the film in water and in
simulated...
This thesis describes in vitro and in vivo evaluation of a gastric retention formulation (GRF) developed at Oregon State University. The formulation was prepared from xanthan gum and locust bean gum as gelling agents and other formulation ingredients were added, then it was originally vacuum oven dried. The effect of...
Acetaminophen has been safely used for analgesia for many years.
Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to
maintain analgesic relief in humans. Current dosing regiments are inconvenient (every
4-6 hours) and do not maintain this minimum plasma level. Simulations were
conducted to examine various doses...
Hot-melt pan-coating, which is a novel coating method and takes 2-3 hours for 300 mg coating weight gain per capsule and tamper-resistant coating, which takes 30 minutes, is much faster than tedious sugar coating and allows greater coating weight gains in shorter times than spray-melt coating. Although hot-melt pan coating...
This dissertation describes the development of a new sustained release formulation of nifedipine. The new formulation was developed by coating commercially available immediate release soft elastic gelatin capsules using a spray coating technique with two different polymeric combinations. Dissolution studies were conducted and showed that controlled release of nifedipine was...
Raw material costs and limited material availability and quality have created
significant interest in and opportunities for the application of nondestructive
evaluation techniques to improve wood processing technologies. The incentives come
from the desire to 1) manufacture the highest valued product, 2) conserve the
amount of raw material used, 3)...
A high-pressure liquid chromatography method based on
reported literature was developed for the quantitative
analysis of chlorpheniramine, pseudoephedrine,
phenylpropanolamine and acetaminophen in dissolution
fluids and urine. The effects of buffer, pH and different
concentrations of organic solvent in the mobile phase on
chromatographic separation are described in Chapter I.
Dissolution...
Bee populations are declining around the globe, while the need for their pollination services is increasing with growing food demands by an expanding population. There is a need for innovative practices to increase pollination in agricultural environments without harming wild bee populations. However, the use of artificial visual attractants has...
Gastrointestinal (GI) transit data were collected using pigs
as animal models. Density and size effects of non-disintegrating
dosage forms on GI transit were investigated. Total GI transit
times range from 2 to 33 days for 22 administrations of these nondisintegrating
dosage forms. Pigs are found to not be an
appropriate...
The major objective of this study was to seek the reactions
of a group of supermarket managers as to what factors they felt were
necessary to a successful performance in their occupation.
One hundred eighty-four managers employed by a western-based
firm which operates stores in ten states returned questionnaires
rating...
This thesis is compromised of two distinct formulation sections, which are described below:
New compression-coated tablet formulations were developed for amoxicillin/clavulanate. Amoxicillin in an outer coat was separated from clavulanic acid in a core tablet by inactive ingredients in a middle coat. A chewable compression-coated tablet formulation with 50% stearic...
Effects of lactobacilli in enteric coated capsules
were studied in piglets (Chapter I). Lactobacillus
acidophilus and Lactobacillus bulgaricus isolated from a
commercial product were formulated in capsules, enteric
coated, and then given to both Escherichia coli-challenged
and unchallenged baby pigs. Decreased
incidence and severity of diarrhea, and decreased weight
deceleration...
Competitive bid sales of U.S. Forest Service in the Pacific Northwest
timber resources have significant effects on the economies of
Oregon, Washington, and Idaho. These sales contribute to the economic
vitality of small regions or communities dependent upon timber as a primary
resource input. Any changes in the price or...