The heartwood of western redcedar (Thuja plicuta) is known for its natural resistance to fungal attack, but some users of western redcedar utility poles have suggested that its durability may be diminished as suppliers begin to harvest trees from younger stands. The decay resistance of western redcedar samples from the...
The potential of 17 hydroxylamine derivatives as wood preservatives was assessed on ponderosa pine sapwood blocks exposed to one of two decay fungi: Gloeophyllum trabeum or Trametes versicolor. Weight losses on untreated controls were generally lower with the white-rot fungus (T. versicolor) averaging 30.4 percent, while those for the brown-rot...
Port Orford cedar (Chamaecyparis lawsoniana) has a reputation for being resistant to fungal attack, but much of the work to support this premise used older growth material (80-100 yr old). Given the tendency for the heartwood from the second growth of some species to be less durable, we evaluated the...
Molds are an increasingly important issue for all building materials, including
wood. While washing with bleach is a commonly recommended method for removing
molds, and the associated discolorations, there is surprisingly little information on the
effectiveness of this treatment. The ability of mold removal treatments to brighten
wood and eliminate...
Heartwood durability of Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco var. menziesii) was studied as a function of vertical and radial position in boles of trees with a wide range of leaf area/sapwood area ratios. Six 34- year-old trees were harvested from each of three plots established 14 years before: very dense,...
Wood that is submerged in fresh water for long periods has increased permeability and other changed properties. Wood that is submerged in salt water may absorb considerable quantities of salts, which may render the wood resistant to microbial colonization. In this report, we describe decay tests on Douglas-fir sapwood and...
The ability of natural and synthetic hinokitiol, as well as a water soluble derivative (hinokitiol sodium salt), to protect wood against fungal attack was examined. Synthetic and natural hinokitiol provided similar protection. All three materials exhibited similar antifungal activity against Aspergillus niger and Penicillium citrinum on yellow poplar wafers at...
A solid, crystalline fumigant (dazomet) with and without a supplemental copper compound was evaluated as an internal decay control treatment on Douglas-fir poles in two long-term field tests. Methylisothiocyanate (MITC), the decomposition
product of dazomet, was used as a measure of effectiveness. MITC levels in the wood were above the...
Bacillus subtilis and essential oils have been explored separately for their ability to limit colonization by wood stain and mold fungi, but neither approach has been completely effective. One alternative strategy would be to combine the bacterial biocontrol with one or more natural products extracts. In this report, the ability...
The Polycomb Repressive Complex 2 (PRC2) catalyzes genome transcription repression through the methylation of lysine residue 27 in the amino terminal region of histone 3 (H3K27me1/2/3) [2], [7]. PRC2 is made up of three highly conserved core subunits: Kmt6, Eed, and Suz12. Accurate distribution of PRC2 is essential for proper...
Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...
PRC2 (Polycomb Repressive Complex 2) mediated gene silencing plays an important role in cell differentiation, stem cell plasticity, and tumor suppression. In fungi, it is also involved in pathogenicity. The catalytic subunit, KMT6, trimethylates lysine 27 on histone h3 (H3K27me3) at loci targeted for silencing. In animals, PRC1 and PRC2...
In eukaryotes, the defined loci on each chromosome, the centromeres, accomplish
the critical task of correct cell division. In some organisms, centromeres are
composed of a euchromatic central core region embedded in a stretch of
heterochromatin and the inheritance and maintenance of centromeres are controlled
by dynamic epigenetic phenomena. Although...
Modifications of histone tail amino acid residues are necessary for many reactions involving chromatin. These processes can produce transcriptionally active, euchromatic, or inactive, heterochromatic, segments of DNA. The formation and maintenance of facultative heterochromatin is critical for the proper growth and development of many eukaryotes. Euchromatin can be changed into...
Fungi are capable of growth on a wide variety of carbon sources, both living and dead. They can produce an arsenal of enzymes and transporters for harvesting sugars, polysaccharides, amino acids, lipids and micronutrients from their environments [1]. Within the nucleus of a cell, transcription factors (TF) control whether genes...
Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase that initiates facultative heterochromatin formation by trimethylating histone H3 on lysine 27 (H3K27me3). Mutations within its three primary subunits, KMT6, EED, and SUZ12, result in inherited diseases and sporadic cancers. In the fungus Fusarium graminearum, deletion of the gene encoding the...
Mutation of repetitive DNA by repeat-induced point mutation (RIP) is a process that occurs in many filamentous fungi of the Ascomycota during the sexual cycle. Concurrently, direct DNA repeats are often deleted by homologous recombination at high frequency during the sexual cycle. Thus, the processes of RIP and deletion compete...
DNA is often described as the “blueprint for life”. In eukaryotes this information is contained within linear chromosomes of varying size and number. During cell division, the chromosomes must be faithfully segregated into each daughter cell to avoid disease and sustain life. This process is carried out by the kinetochore...
In recent years, non-coding DNA has received much attention within the scientific
community. This attention has not only illuminated the mystery behind functionally
important regions like the centromere, but has also brought to light additional important
questions regarding centromere mechanisms, inheritance, and cellular recognition by the
kinetochore, a protein complex...
DNA segments in the fungus Fusarium graminearum were identified as possible genes encoding for chromodomain proteins (CDPs), and targeted for genetic manipulation. Targeted single-gene deletion strains, as wells as GFP-S tag fusion strains, were generated from wildtype F. graminearum protoplasts, and verified strains were screened for phenotypic differences, such as...
BACKGROUND/PURPOSE: Exposure from medical radiation sources are on the rise in the United States. Often the highest potential source of radiation dose to patients and radiology staff occur during interventional radiology procedures performed using fluoroscopy and digital subtraction angiography (DSA) to provide image guidance in minimally invasive surgical procedures. Several...
A new approach is described that offers a risk-informed performance-based (RIPB) framework for quantifying the risk associated with a cyber-attack on a nuclear power generating facility.
The first part of the method involves 1) the creation of a simplified 10 CFR 73.54 compliant cyber infrastructure, 2) modeling of design basis...
Prompt radiation accounts for 3% of the energy released in a nuclear blast. Simulating the prompt radiation will help identify the potential changes to the ambient temperature and pressure of air around the blast. The changes in ambient conditions may alter blast wave effects. The relationship between the energy deposition...
Recent advances in robotics have led to interest in exploring soft robotic technologies as an engineering control for reducing the risk of radiation exposure for workers in the nuclear industry. These emerging “soft” technologies offer many advantages over traditional rigid robotic systems and can perform a wide range of tasks...
Eye plaque brachytherapy is an established technique for the treatment of ocular melanoma that allows for the preservation of the affected eye as well as visual function. A common treatment planning system for eye plaque procedures, Plaque Simulator (PS), assists physicists in calculating the radiation dose to the tumor and...
Understanding the origin and nature of intra specific biodiversity enables us to better conserve and manage animal populations. Biological diversity is seen at different scales and for different traits such as behavior, morphology, physiology, and life history. Behavior is especially important since behavioral changes are believed to precede changes in...
Introduction: A bone deficit is found to persist five years following a hip fracture and 10 years post tibial fracture in adults. We examined the effect of whole body vibration (Vib) as a means for enhancing whole body composition and bone recovery following hindlimb unloading (HU) of adult female rats....
In this dissertation, a novel method for analyzing computed transition states (TS) for organic reactions is disclosed. It introduces the use of localization-delocalization matrices as parameters in a linear free energy relationship to determine the transition state interactions responsible for differences in energy between the major and minor TS in...
Temperature influences the incidence of chemically induced cancer in fish,
with warmer temperatures being associated with higher cancer incidence. The
mechanisms of temperature-modulated chemical carcinogenesis in fish, however,
have not been described in detail. Therefore, one primary objective of this study
was increased understanding of how temperature-modulated genotoxicity of 7,12-...
The purpose of this study was to analyze preservice teachers' talk about gender issues in education through a poststructural feminist theoretical framework. Eighteen Master of Arts in Teaching students volunteered to participate in a seminar. During the seminar the participants wrote about and discussed gender issues in teaching. Data collected...
The purpose of this phenomenological study is to describe how Oregon governors
Barbara Roberts and John Kitzhaber, whose tenures both coincided with the passage
and implementation of property tax limitation measures, determined the community
college budgets within their recommended state budgets. The stories of Robert’s 1993
and Kitzhaber’s 2001 decisions...
Manned missions beyond low-Earth orbit present tremendous, multifaceted radiological challenges. The deep space radiation environment contains high-energy protons and heavy ions, which are not sufficiently shielded by the aluminum alloys that have historically been used in spacecraft. To address these shielding concerns, polymer-based nanocomposites have been proposed. Radiation transport simulations...
The ability to treat Scots pine (Pinus sylvestris) and Norway spruce (Picea abies) with oilborne copper-8-quinolinolate or with waterborne chromated copper arsenate, ammoniacal copper zinc arsenate, or ammoniacal copper quaternary was assessed using commercial treatment facilities in the Pacific Northwest. In general, Scots pine was more easily treated than was...
There is a growing need for an expanded Probabilistic Risk Assessment (PRA) framework that is able to accommodate new uncertainties that are present in Generation 3+ reactor designs. Dynamic PRA (DPRA) can allow for a more realistic risk assessment by taking advantage of established nuclear simulation codes to drive Dynamic...
Compliance with 10CFR 20.101 requires that exposure to the skin be assessed at a depth of 0.007 cm over 10 cm² area. This depth generally corresponds to the interface between the epidermal and dermal layers of the skin. The Nuclear Regulatory Commission states the criteria for evaluating skin dose from...
Traditional robots have a long history in nuclear-related work because their integration decreases risk to humans in dangerous environments. Soft robotics is one promising new branch of traditional robotics with proposed applications in industry, medicine, and society. Collaborators from the Robotics mLab at Oregon State University (OSU) are currently working...
Radiation therapy is used in approximately half of all cancer treatments. The rapid advances in radiation therapy have led to techniques that are much more complex and therefore must be more carefully assessed for safety and efficacy. Accurate quality assurance methods must be implemented to provide patient safety and confidence...
Fission product yields (FPYs) are used for a wide range of applications including nuclear fission theory, nuclear reactor design, reactor antineutrino anomaly, stellar nucleosynthesis, and nuclear forensics. These applications rely on FPYs that were last evaluated in 1993, which included measurements from all over the world up until 1993. In...
In the U.S., the Nuclear Regulatory Commission (NRC) is responsible for setting annual dose limits. For cases of hot particle contamination these limits are set at depths in skin of 7 mg/cm², 300 mg/cm², and 1000 mg/cm². However, at such shallow depths, the lack of charged particle equilibrium (CPE) precludes...
Photoneutron contamination produced during high-energy, external beam radiotherapy can contribute to total patient dose. This aspect of unwanted dose is not currently evaluated for patients undergoing radiation therapy. While multiple studies have examined the neutron dose from beams with energies above 10 MeV, research assessing neutron dose from a 10...
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Camille J. Lodwick
Photoneutron contamination produced during high-energy, external beam
Ophthalmic plaque brachytherapy is a form of internal radiation treatment for uveal melanoma, the most common eye cancer in adults. During treatment, a plaque containing radioactive seeds is surgically attached to the sclera, directly adjacent to the ocular tumor site. Plaque Simulator™ is an eye plaque brachytherapy planning software that...
The Ambrosia Lake West Site is a former uranium recovery facility located north of Grants, New Mexico. It currently serves as a uranium mill tailings site undergoing reclamation and decommissioning. High velocity winds are common in the area, causing soil erosion via aeolian processes. Strong winds may carry soil for...
In a radiological emergency scenario, the capability to rapidly visualize radiation emitted from debris, contamination, or absorbed in biological samples, while visualizing the non-radioactive (or “conventional” image) features within a field of view, will provide critical information to support optimization of further analysis, sample collection, and decision making. This research...