DNA damage, if not repaired, can become a mutation. Mutation
accumulation is associated with initiation and progression of tumorigenesis. DNA
mismatch repair (MMR) is required for maintaining genetic stability by repairing
replication errors. Biochemical studies have shown that MMR also recognizes
mismatch-causing DNA lesions, suggesting the role of MMR in...
The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
Mitotic recombination is a common autosomal mutation in mammalian cells involving crossover events between homologous chromosomes. This process can convert a cell with a heterozygous deficiency to one with a homozygous deficiency, and thus often represents the second step in tumor suppressor gene inactivation. In this study I examined the...
In these tests, phenolic constituents from bark of Shasta red fir were found ineffective as stiffening agents for corrugating medium. Other means of application, however, may be effective.
Gum from inner bark of Shasta red fir was not so effective as a beater additive as was locust bean gum, but...
Many failures of interpersonal communication and coordination in the aircraft cockpit have been found to occur as a result of poor management of flightdeck 'resources'. Crew Resource Management (CRM) is a concept that has evolved within the aviation community to specifically address this issue of resource management. The concept of...
Nearly 9,000 feet of Cretaceous mudstones, shales, sandstone,
and conglomerates are exposed along the northeast-trending Mitchell
anticline of central Oregon, These rocks are divided into two formations
on the basis of criteria developed in this investigation. The
lower formation, hereby designated the Meyers Formation, is 4,716
feet thick at its...
Animal pollination is critical to plant reproduction in agricultural and wildland ecosystems. Much of the production of seeds and fruits in natural areas, which underlie many food webs, depends on pollination services by insects. The taxon responsible for delivering the bulk of these services in most temperate systems is bees....
Ice cores are considered the gold standard for recording past climate and biogeochemical changes. However, gas records derived from ice core analysis have until now been largely limited to centennial and longer timescales because sufficient temporal resolution and analytical precision have been lacking, except during rare times when atmospheric concentrations...
The thesis area covers 165 square miles including the greater
part of the northeastern quarter of the Mitchell quadrangle in north-central Oregon. The three stratigraphic units exposed in the area
consist of a variety of Tertiary volcanic rocks including the Clarno
Formation, the John Day Formation, and the Columbia River...
Long-term durability of surface-bonded carbon fiber-reinforced polymer (CFRP) U-wraps for shear strengthening of reinforced concrete (RC) bridge members remains uncertain due to the limited field experience with these materials. This paper provides experimental results from the testing of full-scale RC bridge girder specimens after exposure to prolonged freeze-thaw cycling. CFRP...
The AAPD recommends placement of dental pit and fissure sealants on surfaces that are high risk or that already exhibit incipient carious lesions. Protection provided by sealants may be enhanced by the addition of ion-releasing, anti-microbial filler particles of bioactive glass.
Objective: We prepared novel dental pit and fissure sealant...
Measurements on growth traits up to 41 years of age
from 68 progeny sites in eight first-generation breeding
zones of coastal Douglas-fir (Pseudotsuga menziesii
[MIRB.] FRANCO var. menziesii) in the US Pacific Northwest
were used to investigate age trends of genetic parameters
and to determine optimum age of selection. Heritabilities...
A high performance liquid chromatography (HPLC)
procedure using a LiChrosorb-NH₂ column and a eluant
buffer of 75:25 (v/v) of acetonitrile:0.05 M KH₂P0₄, pH
5.95, was developed for the successful separation and
determination of ascorbic and erythorbic acids in selected
food samples.
Application of the method, which is sensitive, rapid
and...
Bathers exposed to microbiological contamination in coastal waters have an excess risk of gastrointestinal and respiratory illness. The disease burden associated with this risk may be considerable in Southern California, where 50 million annual beach visitors recreate in coastal waters that receive billions of gallons of polluted discharges from nearby...
A static-renewal, seven day test was developed and
utilized to study the effects of nutrition on the sensitivity
of Mysidopsis intii Holmquist to zinc. It was found that
juvenile growth was the most reliable and sensitive endpoint
that could also reflect the subtle effects of low zinc
concentrations and diet...
Physicists who study semiconductor devices are fascinated by the fundamental limits of device performance. From the sub-threshold swing of transistors to the power conversion efficiency of photocells, performance is limited by the electronic structure of the materials used to build them. To surpass traditional device limits, we must turn to...
Excessive nitrates in drinking water pose a human health threat, especially to infants. Methemoglobinemia, or blue-baby syndrome, is a potentially fatal condition that inhibits the ability of red blood cells to bind and transport oxygen. Nitrates/nitrites have also been linked to such conditions as cancer, birth defects, and behavioral and...
The two most economically important plant pathogens in the Pseudoperonospora (Peronosporaceae) genus are P. cubensis, causal agent of cucurbit downy mildew, and P. humuli, causal agent of hop downy mildew. These organisms have been shown to be very closely related phylogenetically and morphologically. In 2005, researchers in Korea proposed that...
As coastal communities face increasing chronic and acute hazards, nature-based coastal engineering solutions have experienced a rapid growth in popularity and interest. Recent works on this topic have shown that “Green Infrastructure” may be effective at mitigating coastal hazards and therefore provide sustainable adaptation alternatives to traditional engineering solutions such...
Composites often are able to carry more load after damage due to the structure of laminates. In addition, damage can be difficult to detect in composites compared to homogeneous materials. Understanding the behavior of composite material after damage is vital for composite structural design. Currently, experimental methods exist for classifying...
Atomic Layer Deposition (ALD) is a promising technique for the production of
biologically safe, wear resistant and corrosion protective coatings for orthopedic
applications. In this work, the impact of coating thickness and surface preparation on the
hardness (H), elastic modulus (E), wear resistance, and delamination of ALD Al2O3 films
is...
Optimum growth temperatures were determined for nine strains of Streptococcus thermophilus and ten strains of Lactobacillus bulgaricus, all commercial yogurt or yogurt
starter isolates. Optimum growth temperatures ranged from 35 C to 42 C for S.thermophilus strains, averaging 38.6. Optimum growth temperatures for L.bulgaricus strains ranged from 43 C to...
The Clarno Formation is a series of volcanic, volcaniclastic, and related intrusive rocks located in central Oregon. It is the westernmost extent of a broader Eocene magmatic belt that covers much the western United States. The magmatic belt stretches eastward from Oregon to western South Dakota, and from the Canadian...
Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled
signaling pathways. Prior research suggested that some isoforms of PLC-β may exist
and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation
assays of differentially-tagged PLC-β constructs and sizeexclusion
chromatography of native PLC-β support homodimerization...
Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'.
The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
Two forest management objectives being debated in the context of federally managed landscapes in the US Pacific Northwest involve a perceived trade-off between fire restoration and C sequestration. The former strategy would reduce fuel (and therefore C) that has accumulated through a century of fire suppression and exclusion that has...
The anaerobic and highly reductive conditions found in the ovine rumen are considered favorable for the degradation of the nitroaromatic explosives such as hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). In this study, we used stable-isotope-probing to determine the bacteria responsible for the degradation of RDX in the rumen. Results indicate 10 μg mL⁻¹ (45...
The purpose of this.investigation was to determine how enzymes and oxygen influence the role ascorbic acid has on pigment degradation and browning during storage for strawberry juice and concentrate.
The ascorbic and dehydroascorbic acid content of blanched and unblanched, nitrogen-treated and air-exposed samples of strawberry juice and concentrate was measured...
Many biological processes are regulated by the presence and movement of cellular Ca²⁺ ions. The concentration of Ca²⁺ in a cellular environment is regulated by IP₃ sensitive channels that lie on the surface of a cell’s endoplasmic reticulum. Little is known about the macroscopic effects of intracellular Ca²⁺ activity, so...
Three experiments were conducted to evaluate the various
methods and application rates of ferrous sulfate-heptahydrate in
the control of atmospheric ammonia in an enclosed broiler house.
The first experiment was conducted to determine the optimal
rate of application of ferrous sulfate-heptahydrate on built-up
litter. Ferrous sulfate was applied on built-up...
College students need accurate information to both prevent sexual assault and to access services following sexual assault. Effective communication serves an important public health role by reducing both assaults and psychological distress. In contrast, ineffective communication can both increase assaults and psychological distress. Little empirical research is available to guide...
Methods were developed for the co-encapsulation of slow release compounds (SRC) with viable microbial cells in alginate and gellan gum hydrogel beads, for the in-situ aerobic cometabolic treatment of groundwater contaminated with mixtures of 1,4-dioxane and chlorinated aliphatic hydrocarbons, which will be referred to as contaminants of concern (CoC). The...
Modern electronics have created increased demand for innovative cooling solutions. Typical forced convective cooling systems consist of pumps that circulate cooling fluid. However pumps can be unwieldy for many applications. This research is a continuation of work done at Oregon State University and Auburn University on the passive pumping of...
Individuals who have been traumatized have the opportunity to experience posttraumatic growth, conceptualized as positive changes that result from navigating highly challenging life circumstances (Tedeschi & Calhoun, 2004). The current model of posttraumatic growth (Calhoun, Cann, & Tedeschi, 2010) is based solely on cognitive-emotional processing yet by examining the role...