This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Viral infections were investigated in American black bears (Ursus americanus) from Nevada and northern California with and without idiopathic encephalitis. Metagenomics analyses of tissue pools revealed novel viruses in the genera Circoviridae, Parvoviridae, Anelloviridae, Polyomaviridae, and Papillomaviridae. The circovirus and parvovirus were of particular interest due to their potential importance...
Fiber-optic-coupled dosimeters (FOCDs) are a relatively new method in which to obtain in-vivo dose concomitant with radiation treatment. Accurate live dosing can be achieved virtually anywhere due to their small dimensions (0.2 mm) which can be accommodated by a catheter. The purpose of this experiment is to characterize the electron...
How do you test a program when only a single user, with no expertise in software testing, is able to determine if the
program is performing correctly? Such programs are common today in the form of machine-learned classifiers. We consider the
problem of testing this common kind of machine-generated program...
Teacher efficacy continues to be an important area of study in educational research. This study tested an instrument designed to assess the perceived efficacy of agricultural education teachers when engaged in lessons involving mathematics instruction. The study population of Oregon and Washington agricultural educators utilized in the validation of the...
Taiwan separated from China as the result of the 1949 political upheaval between Chiang Kai-Shek's Nationalist Government and Mao Tse-Tung's Communists Party which concluded
with the Chinese Communist take over of mainland China and the establishment of the People's Republic of China. Since then, Taiwan, ROC and the PRC have...
Enabled by a rich ecosystem of Machine Learning (ML) libraries, programming using learned models, i.e., Software-2.0, has gained substantial adoption. However, we do not know what challenges developers encounter when they use ML libraries. With this knowledge gap, researchers miss opportunities to contribute to new research directions, tool builders do...
