Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin-1 receptor–associated kinase 4 (IRAK4) is a critical modulator of inflammation, inhibition of its activity with selective drug molecules (IRAK4 inhibitors) represents a promising therapeutic strategy for inflammatory disorders. To exploit the full potential of this...
Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Textiles (including basketry, cordage, woven, knotted, or plaited products) make up a considerable portion of the perishable archaeological record in dry caves of the northern Great Basin region, much of which is created from plants and plant fibers. The archaeological study of precontact textiles greatly informs our understanding of how...
This study explores an underground museum located in Pendleton, Oregon. Using the method of Critical Discourse Analysis, I identify the ways Whiteness and Chinese as “the Other” are visually and verbally depicted. This study uses a qualitative approach to identify the ways both groups are presented on the tour. The...
Discussions of ecopoetics often seek to investigate how poetics as a form can be rendered more ecological, often in contrast to nature poetry. These conversations tend to concentrate on this generic contrast and the formal qualities of an ecological poetics. Ecopoetics as a field emerged largely as a response to...
Animal welfare is an essential component of agricultural production and animal use in teaching and research. However, defining animal welfare is intrinsically difficult because of how history and societal values and perceptions have shaped the term. Animal welfare encompasses three main ideas: physical well-being, normal affective/emotional states, and the ability...
In the environment, it is the unbound fraction of chemical (Cfree) which is able to diffuse across environmental interfaces and biological membranes. It is therefore Cfree which drives many important biological-environmental processes including contaminant transport, bioaccumulation and toxicity. Passive sampling devices (PSDs) offer a simplified and more accurate approach for...
In recent years, many studies have focused on the molecular and biochemical mechanisms regulating the development of wine grapes. The course of grape berry development is directed by genetic design and is mediated by phytohormones, which regulate grape berry growth and development by orchestrating a complex network of interacting genes,...
To obtain a mechanistic understanding of the chemical processes, techniques that offer a frame-by-frame visualization of molecular structure during a reaction are of vital importance. Numerous efforts and advances have been made in order to acquire such vivid molecular “movies”, especially in the electronic excited state. Ultrafast molecular spectroscopy method...