Index Catalog // ScholarsArchive@OSU

Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents

Creator:: Crowell, Susan Ritger, Amin, Shantu G., Anderson, Kim A., Krishnegowda, Gowdahalli, Sharma, Arun K., Soelberg, Jolen J., Williams, David E., and Corley, Richard A.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants generated as byproducts of natural and anthropogenic combustion processes. Despite significant public health concern, physiologically based pharmacokinetic (PBPK) modeling efforts for PAHs have so far been limited to naphthalene, plus simpler PK models for pyrene, nitropyrene, and benzo[a]pyrene (B[a]P). The dearth of...
Resource Type:: Article
Full Text:: physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents Toxicology

Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

Creator:: Shorey, Lyndsey, Castro, David J., Baird, William, Siddens, Beth, Lohr, Christiane, Matzke, Melissa, Waters, Katrina M., Corley, Richard A., and Williams, David E.
Abstract:: Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver....
Resource Type:: Article
Full Text:: track changes.doc 1 Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

Creator:: Madeen, Erin, Corley, Richard A., Crowell, Susan, Turteltaub, Kenneth, Ognibene, Ted, Malfatti, Mike, McQuistan, Tammie J., Garrard, Mary, Sudakin, Dan, and Williams, David E.
Abstract:: Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
Resource Type:: Article

MadeenErinEMTHumanInVivo.pdf

Creator:: Madeen, Erin, Corley, Richard A., Crowell, Susan, Turteltaub, Kenneth, Ognibene, Ted, Malfatti, Mike, McQuistan, Tammie J., Garrard, Mary, Sudakin, Dan, and Williams, David E.
Abstract:: Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
Full Text:: Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p

MadeenErinEMTHumanInVivo.pdf

Creator:: Madeen, Erin, Corley, Richard A., Crowell, Susan, Turteltaub, Kenneth, Ognibene, Ted, Malfatti, Mike, McQuistan, Tammie J., Garrard, Mary, Sudakin, Dan, and Williams, David E.
Abstract:: Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
Full Text:: Corley, R. A. (2013) Impact of pregnancy on the pharmacokinetics of dibenzo- [def,p]chrysene in mice

Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework

Creator:: Teeguarden, Justin G., Tan, Yu-Mei, Edwards, Stephen W., Leonard, Jeremy A., Anderson, Kim A., Corley, Richard A., Kile, Molly L., Simonich, Staci M., Stone, David, Tanguay, Robert L., Waters, Katrina M., Harper, Stacey L., and Williams, David E.
Abstract:: Driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health, the field of exposure science is undergoing a rapid transition from a field of observation to a field of prediction. Deployment of an organizational and predictive framework for...
Resource Type:: Article
Full Text:: ,‡ Richard A. Corley,‡,† Molly L. Kile,§ Staci M. Simonich,‡ David Stone,‡ Robert L. Tanguay,‡ Katrina M

Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse

Creator:: Siddens, Lisbeth K., Larkin, Andrew, Krueger, Sharon K., Bradfield, Christopher A., Waters, Katrina M., Tilton, Susan C., Pereira, Cliff B., Lohr, Christiane V., Arlt, Volker M., Phillips, David H., Williams, David E., and Baird, William M.
Abstract:: The polycyclic aromatic hydrocarbon (PAH), benzo[a]pyrene (BaP), was compared to dibenzo[def,p]chrysene (DBC) and combinations of three environmental PAH mixtures (coal tar, diesel particulate and cigarette smoke condensate) using a two stage, FVB/N mouse skin tumor model. DBC (4 nmol) was most potent, reaching 100% tumor incidence with a shorter latency...
Resource Type:: Article
Full Text:: aromatic hydrocarbons as skin carcinogens: Comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three

Managing for climate change on federal lands of the western United States: perceived usefulness of climate science, effectiveness of adaptation strategies, and barriers to implementation

Creator:: Kemp, Kerry B., Blades, Jarod J., Klos, P. Zion, Hall, Troy E., Force, Jo Ellen, Morgan, Penelope, and Tinkham, Wade T.
Abstract:: Recent mandates in the United States require federal agencies to incorporate climate change science into land management planning efforts. These mandates target possible adaptation and mitigation strategies. However, the degree to which climate change is actively being considered in agency planning and management decisions is largely unknown. We explored the...
Resource Type:: Article
Full Text:: implementation Kemp, K. B., Blades, J. J., Klos, P. Z., Hall, T. E., Force, J. E., Morgan, P., & Tinkham, W. T

The genome of the water strider Gerris buenoi reveals expansions of gene repertoires associated with adaptations to life on the water

Creator:: Armisen, David, Rajakumar, Rajendhran, Friedrich, Markus, Benoit, Joshua B., Robertson, Hugh M., Panfilio, Kristen A., Ahn, Seung-Joon, Poelchau, Monica F., Chao, Hsu, Dinh, Huyen, Doddapaneni, Harsha Vardhan, Dugan, Shannon, Gibbs, Richard A., Hughes, Daniel S. T., Han, Yi, Lee, Sandra L., Murali, Shwetha C., Muzny, Donna M., Qu, Jiaxin, Worley, Kim C., Munoz-Torres, Monica, Abouheif, Ehab, Bonneton, Francois, Chen, Travis, Chiang, Li-Mei, Childers, Christopher P., Cridge, Andrew G., Crumiere, Antonin J. J., Decaras, Amelie, Didion, Elise M., Duncan, Elizabeth J., Elpidina, Elena N., Fave, Marie-Julie, Finet, Cedric, Jacobs, Chris G. C., Jarvela, Alys M. Cheatle, Jennings, Emily C., Jones, Jeffery W., Lesoway, Maryna P., Lovegrove, Mackenzie R., Martynov, Alexander, Oppert, Brenda, Lillico-Ouachour, Angelica, Rajakumar, Arjuna, Refki, Peter Nagui, Rosendale, Andrew J., Santos, Maria Emilia, Toubiana, William, van der Zee, Maurijn, Jentzsch, Iris M. Vargas, Lowman, Aidamalia Vargas, Viala, Severine, Richards, Stephen, and Khila, Abderrahman
Abstract:: Background: Having conquered water surfaces worldwide, the semi-aquatic bugs occupy ponds, streams, lakes, mangroves, and even open oceans. The diversity of this group has inspired a range of scientific studies from ecology and evolution to developmental genetics and hydrodynamics of fluid locomotion. However, the lack of a representative water strider...
Resource Type:: Article
Full Text:: , Travis Chen14, Li-Mei Chiang10, Christopher P. Childers10, Andrew G. Cridge15, Antonin J. J. Crumière1

Utilization of EpiDerm, a Reconstructed Human Skin Model, in a Translational Mouse to Human Study.pptx

Creator:: Ridinger, Elyssa
Abstract:: Keywords: fuzzy neural network, AHRR, NRF2, DBC, human skin cell, 1A1, 1B1, two-stage mouse model, NFKB1, PAH, translational study, HSP90, environmental pollutant, BaP, AHR, NQO1, skin cancer, polycyclic aromatic hydrocarbons, EpiDerm
Full Text:: ]pyrene (DBP) =Dibenzo[def,p]chrysene (DBC) 4 2-Stage FVB Mouse Skin Tumor Model T-48h; Shave T-0h

ScholarsArchive@OSU

Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents

Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

MadeenErinEMTHumanInVivo.pdf

MadeenErinEMTHumanInVivo.pdf

Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework

Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse

Managing for climate change on federal lands of the western United States: perceived usefulness of climate science, effectiveness of adaptation strategies, and barriers to implementation

The genome of the water strider Gerris buenoi reveals expansions of gene repertoires associated with adaptations to life on the water

Utilization of EpiDerm, a Reconstructed Human Skin Model, in a Translational Mouse to Human Study.pptx

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