Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin-1 receptor–associated kinase 4 (IRAK4) is a critical modulator of inflammation, inhibition of its activity with selective drug molecules (IRAK4 inhibitors) represents a promising therapeutic strategy for inflammatory disorders. To exploit the full potential of this...
As we contemplate the future of forest landscapes under changing climate conditions and land-use demands, there is increasing value in studying historic forest conditions and how these landscapes have changed following past disturbances. Historic landscape paintings are a potential source of data on preindustrial forests with highly detailed, full-color depictions...
Technological advancements, ever-evolving necessary skillsets, and an aging workforce have all contributed to a growing labor crisis wherein there are not enough qualified candidates available to fill vacant jobs in the manufacturing sector – in essence, a skilled labor shortage. Certificate programs (earned independently in a two-year college, while working...
The engineering community is increasingly moving towards the design of seismic force-resisting systems that limit post-earthquake damage and reduce downtime to increase urban resiliency. For example, structural spines can be used to provide an elastic load path to impose a more uniform drift distribution with building height, thereby reducing the...
These datasets were used in the prospective meta-analysis of northern spotted owl reproductive rates over 25 years across 11 study areas located throughout the range of the owl. A multi-state occupancy file was created by collapsing site-specific information on owl reproductive status into bimonthly (2 per month) survey occasions. These...
The Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (JPEO-CBRND) began development of a broad-spectrum antiviral countermeasure against deliberate use of high-consequence viral hemorrhagic fevers (VHFs) in 2016. The effort featured comprehensive preclinical research, including laboratory testing and rapid advancement of lead molecules into nonhuman primate (NHP)...
In the United States, the wild horse population exceeds the recommended carrying capacity by about 60,000 horses.
• Current contraceptive methods include: surgical (removal of ovaries), hormonal (progesterone, GnRH), and immunologic (porcine zona pellucida, GnRH).
• SPACA3 is a sperm surface membrane protein involved in sperm-egg plasma membrane adhesion and...
Photosynthetic diatoms and marine bacteria contribute about one third of the net primary production in marine environments. Understanding the interactions between these two organisms is potentially important to the over all flow of carbon in the marine ecosystem.
These datasets were used in the prospective meta-analysis of northern spotted owl reproductive rates over 25 years across 11 study areas located throughout the range of the owl. A multi-state occupancy file was created by collapsing site-specific information on owl reproductive status into bimonthly (2 per month) survey occasions. These...
In a radiological emergency scenario, the capability to rapidly visualize radiation emitted from debris, contamination, or absorbed in biological samples, while visualizing the non-radioactive (or “conventional” image) features within a field of view, will provide critical information to support optimization of further analysis, sample collection, and decision making. This research...