This report includes information concerning experimental use of unregistered pesticides or unregistered uses of pesticides. Experimental results should not be interpreted as recommendations for use. Use of unregistered materials or use of any registered pesticides inconsistent with its label is against both Federal Law and State Law.
In recent years considerable interest has been shown in the diversity of ammonia-oxidizing bacteria in soil communities. The majority of the research has been carried out in Northern Europe where soils have received high atmospheric inputs of nitrogen over the past two centuries. In contrast, although much work has been...
The purpose of this study is to investigate the performance and stability of
the gas-injection enhanced natural circulation in heavy-liquid-metal-cooled systems.
The target system is STAR-LM, which is a 400-MWt-class advanced lead-cooled
fast reactor under development by Argonne National Laboratory and Oregon State
University. The primary loop of STAR-LM relies...
Phosphorodiamidate morpholino oligomers (PMOs) are novel antisense drugs in the early stages
of development. These synthetic DNA mimics contain the same bases found in DNA and anneal
to RNA in a complementary fashion. PMOs have been designed that target genes responsible for
producing essential proteins in organisms such as Escherichia...
Bovine viral diarrhea virus (BVDV) is an enveloped, single-stranded positive-sense RNA virus. The BVDV genome is about 12.5 kb long and consists of a single open reading frame (ORF) flanked by untranslated regions at the 5' and 3' ends (5'-UTR and 3'- UTR, respectively). To investigate the role of cis-sequences...
Two different types of Phosphorodiamidate Morpholino Oligomers (PMOs) were used to
inhibit growth in pure cultures of Salmonella enterica serovar typhimurium and in mouse
macrophages infected with S. typhimurium. Both PMOs were 11 bases long and
complementary to bases 6-16 of acyl carrier protein mRNA. A membrane-penetrating
peptide, (RXR)4XB, was...
Influenza A and Respiratory Syncytial Virus (RSV) are both enveloped, negative strand
RNA viruses which infect the respiratory mucosa of animals and humans. Despite
decades of research and development of antivirals and vaccines, both of these viruses
continue to be a major health concern throughout the world. The focus of...
Exon skipping is capable of correcting frame-shift and nonsense mutations of
Duchenne Muscular Dystrophy (DMD). Phase II clinical trials in UK and Netherlands
have reported induction of dystrophin expression in muscles of DMD patients by
systemic administrations of both phosphorodiamidate morpholino oligomers (PMO)
and 2’O methyl phosphorothioate. Peptide-conjugated PMO (PPMO)...
As the aging population continues to grow worldwide, age-related complications are becoming more apparent within the aging population. One of the first age-related complications to become apparent is age-associated memory impairment and it can make the elderly more dependent on caregivers early on. The N-methyl-D-aspartate (NMDA) receptor is important to...
Peptide phosphorodiamidate morpholino oligomers (PPMO) are synthetic DNA mimics that bind complementary RNA and inhibit bacterial gene expression. (RFF)₃RXB- AcpP PPMO (R, arginine; F, phenylalanine; X, 6-aminohexanoic acid; B, β-alanine) is complementary to 11 bases of the essential gene acpP (encodes acyl carrier protein). The MIC of (RFF)₃RXB-AcpP was 2.5...