The viral family Herpesviridae consists of large double stranded DNA viruses including eight species that infect humans with varying pathology from benign rashes to cancerous cell transformation. From three subfamilies, alpha-, beta- and gammaherpes, the alphaherpes contains the genera iltovirus, mardivirus, varicellovirus and simplex, two of which, the human simplex...
Ocular infection by HSV-1 strain McKrae is neurovirulent in both mice and rabbits and causes fatal encephalitis in approximately 50% of animals. In addition, it spontaneously reactivates with high frequency relative to other HSV-1 strains in rabbits. We sequenced the McKrae strain genome and compared its coding protein sequences with...
The genome of a herpesvirus highly pathogenic to rabbits, leporid herpesvirus 4 (LHV-4), was analyzed using high-throughput DNA sequencing technology and primer walking. The assembled DNA sequences were further verified by restriction endonuclease digestion and Southern blot analyses. The total length of the LHV-4 genome was determined to be about...
miRNA-guided cleavage initiates entry of primary transcripts into the trans-acting siRNA (tasiRNA) biogenesis pathway involving RNA-DEPENDENT RNA POLYMERASE6 (RDR6), DICER-LIKE 4 (DCL4), and SUPPRESSOR OF GENE SILENCING3 (SGS3). Arabidopsis thaliana TAS1 and TAS2 families yield tasiRNA that form through miR173- guided initiation cleavage on the 5’ side of the siRNA-generating...
The objective of this research was to determine if acupuncture can reduce bovine mammary inflammation. Lactating cows at the Oregon State University Dairy Research Center were selected based on Dairy Herd Improvement Association reports indicating a SCC >500,000 cells/mL. A California Mastitis Test (CMT) score of greater than one was...
The interaction of magma with continental crust at convergent margins is fundamental to
understanding if and how continents grow. Isotopic and elemental data constrain the
progressive stages of development of the magmatic underpinnings of the long-lived
Aucanquilcha Volcanic Cluster (AVC), situated atop the thick continental crust of the
central Andes...
Full Text:
slow and murky
beginning, but Bobby Babra encouraged me, played with me and even wrote with me,
and