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  • Fibrinogen adsorption at heparinized silica interfaces : history dependence and adsorption time effects

    Creator:
    Lee, Hyo Jin
    Abstract:
    Heparin was modified with adipic diliydrazide and covalently linked to surface-activated silica. Contact angle measurements were made to determine changes in surface at various stages of the derivatization. Xray photoelectron spectroscopy was used to analyze the elemental composition of the surface at each step of immobilizing heparin as well and...
    Resource Type:
    Masters Thesis
    Full Text:
    effect of history dependence observed to be more pronounced on the heparinized silica. It is believed

  • Human platelet adhesion to heparinized silica surfaces

    Creator:
    Bolsinger, Travis Samuel Sebastian
    Abstract:
    Heparin was modified and immobilized to surface-activated silica surfaces using two different reaction schemes. End-aminated heparin was reacted with 2-iminothiolane to produce free thiol groups at the terminal ends of the heparin chains. The end-thiolated heparin was immobilized by reaction with a pyridyl disulfide activated poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] triblock...
    Resource Type:
    Masters Thesis
    Full Text:
    functionalized silica..…..........…… 38 CHAPTER 1 INTRODUCTION Biomedical devices, such as

  • Fibrinogen adsorption at heparinized silica interfaces : history dependence and protein concentration effects

    Creator:
    Joshi, Omkar
    Abstract:
    Adipic dihydrazide-modified heparin was prepared and subsequently immobilized on surface-activated silica wafers. X-ray photoelectron spectroscopy (XPS) was used to quantify the elemental composition of the silica surface at each stage of activation and results showed that successful immobilization had taken place. Contact angle measurements were made to verify the high...
    Resource Type:
    Masters Thesis
    Full Text:
    material. Noted researcher Buddy Ratner has referred to this problem as the "blood compatibility