The fate of hexachlorophene, a widely used bactericide, was
investigated using both intact male rats and rabbits and liver microsomes
from male rats. Hexachlorophene administered intraperitoneally
was found to be rapidly absorbed and distributed to all the
tissues of the animals. Excretion of the chemical in both species
occurred slowly,...
The subcellular fractions of liver and kidney from three bearded
seals (Erignathus barbatus nauticus) and three walrus (Odobenus
rosmarus divergens) were analyzed for cadmium and mercury content,
and the results were compared with the results of subcellular
fractionation of the same organs from two sea lions (Zalophus callfornianus
californianus) obtained...
The effects of a sublethal concentration of dieldrin (0. 2 ppb)
in the water on the growth and body composition of underyearling rainbow
and cutthroat trout held in aquaria and fed different rations of tubificid
worms or Oregon moist pellets were studied at Oak Creek Fisheries
Research Laboratory, Oregon State...
Hexachlorophene (HCP; 2,2'-methylenebis-(3,4,6-trichlorophenol))
was developed as an antibacterial agent but was also found to induce
toxic effects in various tissues in animals and humans. Changes were
found in myelinated nerve fibers and cerebral white matter. Erythrocytes
are hemolysed in vitro. Oxidative phosphorylation is uncoupled
by HCP at concentrations less than...
Low concentrations of hexachlorophene (HCP) inhibit a number of pyridine nucleotide-linked dehydrogenase enzymes. The I₅₀ HCP concentrations were 105 μM for pig heart isocitrate dehydrogenase (ICD), 65 μM for horse liver alcohol dehydrogenase, 39 μM for torula yeast glucose-6-phosphate dehydrogenase (G6PD), 6.0 μM for beef heart malate dehydrogenase, and 1.6...
Senecio jacobaea (tansy ragwort) is a common weed in the
Pacific Northwest that contains toxic pyrrolizidine alkaloids
(PAs). Jacobine, the major PA in Senecio jacobaea, was incubated
with rat liver microsomes and metabolites were isolated by high
performance liquid chromatography (HPLC) and identified by mass
spectrometric analysis. Metabolites included a...
Aquatic animals are exposed to a variety of natural and
anthropogenic xenobiotics. Biotransformation of xenobiotics was
examined in three aquatic animals: a primitive mollusc (chiton);
a shellfish which is an important human food source (oyster);
and, a lower vertebrate model for toxicological studies (rainbow
trout). Since digestive glands of Cryntochiton...