Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Full Text:
. Bhat, Jeff M. Blaney, Evan Bolton, Gerard Bricogne, David
Brown, StephenK. Burley, David A. Case, Kirk
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Full Text:
Bolton,9 Gerard Bricogne,10 David Brown,11,12 StephenK. Burley,5,6,13,* David A. Case,6
Kirk L. Clark
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
The preservation of land, such as wetlands and agricultural
lands, is often pursued through traditional methods such as zoning or
eminent domain. Transferable Development Rights provides a different
approach to the preservation of land by allowing the sale and transfer
of development rights from land to be protected to land...
The influence of overstory openness on the reproductive
ecology of Pacific yew (Taxus brevifolia Nutt.) was
investigated on 4 sites in western Oregon over 2 years. The
breeding system of T. brevifolia was found to deviate from
pure dioecy under a broad range of canopy and site
conditions. Production of...
Anchors resistant to tensile loads are commonly used in civil engineering practice. Anchors in the marine environment are most frequently used for the mooring of vessels. Only recently, with the expansion of the offshore industry, has the need to develop more reliable anchor systems become necessary. Embedded plate anchors are...
The use of electronic cigarettes (often referred to as vapes or e-cigs) has grown rapidly in the past decade. While these devices may not deliver the same level of carcinogens and toxicants as combustible cigarettes, they can deliver nicotine (a known developmental toxicant) as efficiently. Previous work suggests that, during...
The Soil Conditioning Index (SCI) aids the conservationist in designing crop rotations and residue management practices when low organic matter, poor soil tilt, and crusting problems are identified. The Natural Resources and Conservation Services (NRCS) field staff and others use the SCI as a qualitative tool during conservation planning. In...
The heritability of resistance to eastern filbert blight, caused by Anisogramma anomala, in European hazelnut (Corylus avellana) was evaluated in the progeny of seven cultivars crossed in 12 combinations. Progeny produced by crossing 'VR6-28' with three susceptible cultivars segregated 1:1 for complete resistance to eastern filbert blight. Histograms of disease...