Genetic code expansion (GCE) is a technology that allows us to incorporate noncanonical amino acids (ncAAs) site-specifically into recombinant proteins using engineered translational machinery. Typically, an orthogonal aaRS/tRNA pair is engineered by directed evolution to recognize the ncAA and incorporate it at a reassigned codon while not interacting with the...
Polyphenolic compounds found in foods such as fruits, vegetables, legumes, nuts and grains, are an integral part of the human diet. Within polyphenols, proanthocyanidins are referred to as condensed tannins and encompass procyanidins, propelargonidins and prodelphinidins. Among these, procyanidins are the largest group. Recent interest in these compounds is related...
Superwarfarins are anticoagulant rodenticides that are 100 times more potent and 15 times more persistent than warfarin. They have been used since the 1980s and cause over 10,000 cases of accidental and intentional poisonings per year. Apart from inducing uncontrollable bleeding, by inhibiting the vitamin K cycle, superwarfarins can disrupt...
Popular botanical dietary supplements marketed for management of menopausal symptoms, including hops (Humulus lupulus L.), red clover (Trifolium pratense) and licorice (Glycyrrhiza uralensis), were evaluated for their potential to alter CYP-mediated drug metabolism clinically and pre-clinically. Both hops and red clover had been reported to inhibit certain cytochrome P450 (CYP)...
Techniques have been developed for measuring the
temperature, stable species concentrations, and atomic
radical concentrations during a transient combustion
event. They combine the features of direct sampling with
two spectroscopic techniques to produce relatively simple
diagnostic techniques to obtain time-resolved
measurements. In this study, a transient event was
provided by...
When trace quantities of an alkali element are added to a flame,
its optical and electrical properties change significantly. Addition of
alkali seed to both premixed and diffusion flames has been used in the
development of two new techniques, one for flame temperature measurement
and the other for enhanced mixing....
A continuous process for the production of ceramic materials has been studied.
This method reacted metal and oxidizer in a diffusionally controlled process,
demonstrated by reacting a magnesium particle stream and hot water vapor. Many small
rich hydrogen/air diffusion flames provide an atmosphere of hot water vapor, hydrogen,
and nitrogen...
A resonantly-coupled α-Stirling (RCAS) cooler was designed and constructed.
Tests on air and helium were performed with constant driving displacement over a range
of frequencies. The effects of changing driving amplitude and charged pressure were
studied.
The use of stainless steel bellows in place of pistons eliminated the problem of...
A phase sensitive measurement technique that permits the simultaneous determination
of two independent thermal properties of thin dielectric films is presented. Applying the technique results in a film's thermal diffusivity and effusivity, from which the thermal conductivity and specific heat can be calculated. The technique involves measuring a specimen's front...