Index Catalog // ScholarsArchive@OSU

Transcriptomic Analyses of Crop Plants using Next-Generation Sequencing Technology

Creator:: Geniza, Matthew J.
Abstract:: Advancements in molecular biology and computer science have enabled researchers the ability to investigate the transcriptome – the quantification of an organism’s RNA transcripts in response to its environment on a system wide scale. The collective chapters of this thesis utilize high-throughput RNA sequencing, which produces hundreds of millions of...
Resource Type:: Dissertation
Full Text:: members of my graduate committee: Laurent Deluc, Yuan Jiang, Hiro Nonogaki, and Kari van Zee – thank you

Hepatic Gene Expression Patterns in C57BL/6J Mice Fed High-Fat Diets Supplemented with Watermelon Flesh, Arginine, Citrulline, Lycopene, or S-methylmethionine

Creator:: Chen, Mikayla Y.
Abstract:: About one third of Americans have metabolic syndrome, which is characterized by five risk factors related to blood pressure and triglyceride levels and could lead to diabetes and heart disease if left untreated. Watermelon has been shown to exhibit cardioprotective effects due to its high phytochemical content and may act...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kari van Zee, Committee Member, representing the Department of Biochemistry and Biophysics

Cloning the zebrafish otoferlin b wildtype and a transmembrane mutant to characterize changes in cellular localization

Creator:: France, Rebecca A.
Abstract:: Otoferlin is a protein that is essential in the process of hearing. Mutations in otoferlin are associated with profound recessive deafness. The long-term goal of the Johnson lab is to understand how otoferlin contributes to hearing and why certain mutations result in deafness. This project sought to characterize the difference...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kari van Zee, Committee Member, representing Biochemistry and Biophysics

The role of the putative transcription factor DIS10 in PRC2-mediated gene silencing

Creator:: Jackson, Kendra K.
Abstract:: PRC2 (Polycomb Repressive Complex 2) mediated gene silencing plays an important role in cell differentiation, stem cell plasticity, and tumor suppression. In fungi, it is also involved in pathogenicity. The catalytic subunit, KMT6, trimethylates lysine 27 on histone h3 (H3K27me3) at loci targeted for silencing. In animals, PRC1 and PRC2...
Resource Type:: Honors College Thesis
Full Text:: ____________________________________________________________________ Kari van Zee, Committee Member, representing Biochemistry and Biophysics

Creation of At This Point, an undergraduate-focused science podcast

Creator:: Puoci, Victor (Tori) M.
Abstract:: At This Point, an undergraduate-focused science podcast, works to expand the accessibility of science by exploring topics that, at this point, may seem too complex to understand. This thesis project describes the process of creating At This Point and demonstrates how the podcast fulfills the criteria of effective science communication....
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kari van Zee, Committee Member, representing Department of Biochemistry and Biophysics

The Role of Nrf2 in Brain Cellular Senescence

Creator:: Ross, Grace K.
Abstract:: Aging is a major risk factor for the deterioration of biochemical pathways that lead to many chronic neurodegenerative disorders (i.e. Parkinson’s and Alzheimer's Disease). Cellular senescence is a hallmark of aging, a condition characterized by stable growth arrest resulting in a cell that no longer divides, but is metabolically active....
Resource Type:: Honors College Thesis
Full Text:: Medicine _____________________________________________________________________ Kari Van Zee

A Panel of Histone H3 Mutations to Investigate Centromere Maintenance and Gene Silencing

Creator:: Geisler, Mark S.
Abstract:: Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kari van Zee, Committee Member, representing Biochemistry

Generation of expression plasmids to study the function of the PRC2 subunit Suz12 in Fusarium graminearum

Creator:: Park, Catherine
Abstract:: The Polycomb Repressive Complex 2 (PRC2) catalyzes genome transcription repression through the methylation of lysine residue 27 in the amino terminal region of histone 3 (H3K27me1/2/3) [2], [7]. PRC2 is made up of three highly conserved core subunits: Kmt6, Eed, and Suz12. Accurate distribution of PRC2 is essential for proper...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kari van Zee, Committee Member, representing Biochemistry and Biophysics

Chemistry and Grit: The Impact of Prerequisites vs Perseverance on Academic Success in Biology

Creator:: Sparks, Kiersten E.
Abstract:: Previous research on academic success in biology has focused on the influence of prerequisite knowledge and cognitive ability as measured by course grades or GPA. More recently, the field has considered the influence of non-cognitive factors such as grit, defined as passion and perseverance for long term goals. Both grit...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kari van Zee, Committee Member, representing Department of Biochemistry and Biophysics

Catalysis of Biologically Relevant Chlorination Reactions by Nicotine, and Potential Relevance to Tissue Damage

Creator:: Dolan, Brigh G.
Abstract:: This work is concerned with determining whether nicotine has a role in promoting oxidative damage in human tissue, particularly in lung tissue. This follows from recent reports of a novel lung disease found in some E-cigarette users, characterized by oxidative damage and elevated levels of neutrophils (termed “vaping disease”). It...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kari van Zee, Committee Member, representing Biochemistry and Biophysics

ScholarsArchive@OSU

Transcriptomic Analyses of Crop Plants using Next-Generation Sequencing Technology

Hepatic Gene Expression Patterns in C57BL/6J Mice Fed High-Fat Diets Supplemented with Watermelon Flesh, Arginine, Citrulline, Lycopene, or S-methylmethionine

Cloning the zebrafish otoferlin b wildtype and a transmembrane mutant to characterize changes in cellular localization

The role of the putative transcription factor DIS10 in PRC2-mediated gene silencing

Creation of At This Point, an undergraduate-focused science podcast

The Role of Nrf2 in Brain Cellular Senescence

A Panel of Histone H3 Mutations to Investigate Centromere Maintenance and Gene Silencing

Generation of expression plasmids to study the function of the PRC2 subunit Suz12 in Fusarium graminearum

Chemistry and Grit: The Impact of Prerequisites vs Perseverance on Academic Success in Biology

Catalysis of Biologically Relevant Chlorination Reactions by Nicotine, and Potential Relevance to Tissue Damage

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