Index Catalog // ScholarsArchive@OSU

Small RNA binding is a common strategy to suppress RNA silencing by several viral suppressors

Creator:: Lakatos, Lóránt, Csorba, Tibor, Pantaleo, Vitantonio, Chapman, Elisabeth J., Carrington, James C., Liu, Yu-Ping, Dolja, Valerian V., Calvino, Lourdes Fernández, López-Moya, Juan José, and Burgyán, József
Abstract:: RNA silencing is an evolutionarily conserved system that functions as an antiviral mechanism in higher plants and insects. To counteract RNA silencing, viruses express silencing suppressors that interfere with both siRNA- and microRNA-guided silencing pathways. We used comparative in vitro and in vivo approaches to analyse the molecular mechanism of...
Resource Type:: Article
Full Text:: López-Moya5 and József Burgyán1,* 1Agricultural Biotechnology Center, Plant Biology Institute

Cellular biology

Creator:: Biology Colloquium (15th : 1954 : Oregon State University)
Resource Type:: Book
Full Text:: linkages are used to link the 10 CELLULAR BIOLOGY Figure 13 . small molecules and to form the long

Omega-3 Fatty Acid Supplementation and Cardiovascular Disease

Creator:: Jump, Donald B., Depner, Christopher M., and Tripathy, Sasmita
Abstract:: Epidemiological studies on Greenland Inuits in the 1970s and subsequent human studies have established an inverse relationship between the ingestion of omega-3 fatty acids [C₂₀₋₂₂ ω3 polyunsaturated fatty acids (PUFA)], blood levels of C₂₀₋₂₂ ω3 PUFA and mortality associated with cardiovascular disease [CVD]. C₂₀₋₂₂ ω3 PUFA have pleiotropic effects on...
Resource Type:: Article

A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein

Creator:: Gu, Xiaodong, Wu, Zhiping, Huang, Ying, Wagner, Matthew A., Baleanu-Gogonea, Camelia, Mehl, Ryan A., Buffa, Jennifer A., DiDonato, Anthony J., Hazen, Leah B., Fox, Paul L., Gogonea, Valentin, Parks, John S., DiDonato, Joseph A., and Hazen, Stanley L.
Abstract:: The interaction of lecithin-cholesterol acyltransferase (LCAT) with apolipoprotein A-I (apoA-I) plays a critical role in highdensity lipoprotein (HDL) maturation.Wepreviously identified a highly solvent-exposed apoA-I loop domain (Leu¹⁵⁹–Leu¹⁷⁰) in nascent HDL, the so-called “solar flare” (SF) region, and proposed that it serves as an LCAT docking site (Wu, Z., Wagner, M....
Resource Type:: Article
Full Text:: Cellular and Molecular Medicine, Lerner Research Institute, and the **Department of Cardiovascular Medicine

Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., Gafken, Philip R., Soge, Olusegun O., Holmes, King K., Jerse, Ann E., Unemo, Magnus, and Sikora, Aleksandra E.
Abstract:: Expanding efforts to develop preventive gonorrhea vaccines is critical because of the dire possibility of untreatable gonococcal infections. Reverse vaccinology, which includes genome and proteome mining, has proven very successful in the discovery of vaccine candidates against many pathogenic bacteria. However, progress with this approach for a gonorrhea vaccine remains...
Resource Type:: Article
Full Text:: Society for Biochemistry and Molecular Biology, Inc. This paper is available on line at http

Ribonucleotide Reductase Association with Mammalian Liver Mitochondria

Creator:: Chimploy, Korakod, Song, Shiwei, Wheeler, Linda J., and Mathews, Christopher K.
Abstract:: Deoxyribonucleoside triphosphate pools in mammalian mitochondria are highly asymmetric, and this asymmetry probably contributes toward the elevated mutation rate for the mitochondrial genome as compared with the nuclear genome. To understand this asymmetry, we must identify pathways for synthesis and accumulation of dNTPs within mitochondria. We have identified ribonucleotide reductase...
Resource Type:: Article
Full Text:: R1 and R2 (data not shown). However, the estimated molecular weights of immunoreactive material

Yeast POS5 NADH Kinase: Effects of a Mitochondrial Mutator Mutation on Mitochondrial Nucleotides

Creator:: Wheeler, Linda J. and Mathews, Christopher K.
Abstract:: Saccharomyces cerevisiae contains three NAD⁺/NADH kinases, one of which is localized in mitochondria and phosphorylates NADH in preference to NAD⁺. Strand et al (Euk. Cell 2:809 (2003)) reported that a yeast mutation in POS5, which encodes the mitochondrial NADH kinase, is a mutator, specific for mitochondrial genes. Because of the...
Resource Type:: Article
Full Text:: separation of cellular functions. J. Biol. Chem. 281, 22439–22445 9. Glick, B. S., and Pon, L. (1995

Elovl5 Regulates the mTORC2-Akt-FOXO1 Pathway by Controlling Hepatic cis-Vaccenic Acid Synthesis in Diet-Induced Obese Mice

Creator:: Tripathy, Sasmita and Jump, Donald B.
Abstract:: Elevated hepatic expression of fatty acid elongase-5 (Elovl5) induces FoxO1 phosphorylation, lowers FoxO1 nuclear content and suppresses expression of genes involved in gluconeogenesis. In this report we define the molecular and metabolic basis of Elovl5 control of FoxO1 phosphorylation. Adenoviral-mediated (Ad-Elovl5) induction of hepatic Elovl5 in diet induced obese-glucose intolerant...
Resource Type:: Article
Full Text:: Cellular Biology 29:5657-5670. 40. Julien, L.A., Carriere, A., Moreau, J., and Roux, P.P. 2010. mTORC1

KarplusPAndrewBiochemistryBiophysicsCysteineDioxygenaseStructures.pdf

Creator:: Driggers, Camden M., Cooley, Richard B., Sankaran, Banumathi, Hirschberger, Lawrence L., Stipanuk, Martha H., and Karplus, P. Andrew
Abstract:: Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes 2 the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. 3 One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active 4 site, but quantum mechanical calculations have been used...
Full Text:: : Consistent Cys-Persulfenate Formation at Intermediate pH and a Cys-Bound Enzyme at Higher pH 1 Cysteine

Interactions of yeast dynein with dynein light chain and dynactin: General implications for intrinsically disordered duplex scaffolds in multi-protein assemblies

Creator:: Jie, Jing, Löhr, Frank, and Barbar, Elisar
Abstract:: Intrinsically disordered protein (IDP) duplexes composed of two IDP chains cross-linked by bivalent partner proteins form scaffolds for assembly of multiprotein complexes. The N-terminal domain of dynein intermediate chain (N-IC) is one such IDP that forms a bivalent scaffold with multiple dynein light chains including LC8, a hub protein that...
Resource Type:: Article
Full Text:: controls diverse cellular processes including centrosome separation and movement, mitotic spindle

ScholarsArchive@OSU

Small RNA binding is a common strategy to suppress RNA silencing by several viral suppressors

Cellular biology

Omega-3 Fatty Acid Supplementation and Cardiovascular Disease

A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein

Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea

Ribonucleotide Reductase Association with Mammalian Liver Mitochondria

Yeast POS5 NADH Kinase: Effects of a Mitochondrial Mutator Mutation on Mitochondrial Nucleotides

Elovl5 Regulates the mTORC2-Akt-FOXO1 Pathway by Controlling Hepatic cis-Vaccenic Acid Synthesis in Diet-Induced Obese Mice

KarplusPAndrewBiochemistryBiophysicsCysteineDioxygenaseStructures.pdf

Interactions of yeast dynein with dynein light chain and dynactin: General implications for intrinsically disordered duplex scaffolds in multi-protein assemblies

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