Peptide phosphorodiamidate morpholino oligomers (PPMO) are synthetic DNA mimics that bind complementary RNA and inhibit bacterial gene expression. (RFF)₃RXB- AcpP PPMO (R, arginine; F, phenylalanine; X, 6-aminohexanoic acid; B, β-alanine) is complementary to 11 bases of the essential gene acpP (encodes acyl carrier protein). The MIC of (RFF)₃RXB-AcpP was 2.5...
Increasing numbers of individuals aspire to, seek out, and need a college degree in order to be competitive in the job market (Goyette, 2008; U.S. Department of Education, 2013). College degrees provide access to economic, social, and health benefits (Abel & Deitz, 2014; Autor, 2014). The United States also needs...
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that...
Peroxisome proliferator-activated receptors (PPARs) are members of a
large group of ligand-regulated transcription factors that includes nuclear
receptors for steroid and thyroid hormones, retinoids and vitamin D₃.
Synthetic fibrates and thiazolidinediones that bind to and activate PPARs are
used efficaciously in humans to remedy hypertriglyceridemia and non-insulin
dependent diabetes mellitus,...
Two novel and highly related C₂H₂ zinc finger proteins (CTIP1/BCL11A/EVI9 and CTIP2/BCL11B/Rit1) have been implicated in COUP-TF signaling, etiology of myeloid and lymphoid malignancies, and hematopoietic cell development. However, the precise cellular function(s) and the contribution of these proteins to neoplastic processes and hematopoietic cell development remain unknown. The goal...
The purpose of this study was to identify the strategies and tactics community college presidents used to influence state legislators. Selected State Board for Community and Technical Colleges staff and legislative staff members were asked to independently name 3-5 presidents whom they perceived to be most influential with legislators. Ten...
Novel mucosal vaccines (LL-M2e, LL-HAe, SG-HAe) were constructed from live, non-pathogenic Lactococcus lactis or Streptococcus gordonii that express conserved regions of HA or M2 antigens from avian influenza virus (AIV) A. All three vaccines evoked antigen-specific serum immunoglobulin G (IgG) responses in vaccinated chickens. The addition of the adjuvant cholera...