This thesis explores how female characters in the Zorro and Robin Hood stories have changed throughout time, from beginnings until present day. I began my analysis by first researching whether Zorro and Robin Hood existed, and found that Robin Hood was most likely a real man who lived during the...
CTIP2 is a C2H2 zinc finger transcription factor that plays important yet poorly understood roles in mouse development. CTIP2 is known to be highly expressed in the central nervous system, skin and T lymphocytes during embryogenesis. CTIP2-null mice die perinatally of unknown causes and exhibit defects in multiple organ systems...
Two essays are focused on semiparametric econometric methods. The first essay investigates applicability of the smooth back tting estimator (SBE) to statistical analysis of residential energy consumption. The second essay attempts to incorporate additivity restrictions into semiparametric stochastic frontier estimation. The procedure described in the first study is used to...
This project was a part of larger work that compared major factors controlling patterns of carbon dynamics in two regions of the globe, the Pacific Northwest, USA and northwestern Russia. It was funded through the NASA foundation (grant # NAG5- 6242). Human economic activity is causing the release of pollutants...
We developed, synthesized, and tested a multifunctional nanostructured lipid nanocarrier- based system (NLCS) for efficient delivery of an anticancer drug and siRNA directly into the lungs by inhalation. The system contains: (1) nanostructured lipid carriers (NLC); (2) anticancer drug (doxorubicin or paclitaxel); (3) siRNA targeted to MRP1 mRNA as a...
Thiamin and ascorbic acid content and retention were determined
in raw, blanched, pouched and canned green beans immediately
after processing and after storage for four months at room temperature
or at 37.5°C. Ascorbic acid was also determined in raw, pouched
and canned Royal Ann cherries immediately after processing and after...
The quantity and characteristics of coarse woody debris (CWD) were examined in four distinct pine ecosystems of north-western (NW) Spain, NW Russia and the NW USA. The average CWD volume and biomass ranged from 3.76 m³ ha⁻¹, 1.55 Mg ha⁻¹ in pine plantations in NW Spain to 24.86 m3 ha⁻¹,...
Changes in climate caused by increased concentrations of carbon dioxide (CO₂) in the Earth’s atmosphere have led land and ocean surface temperatures to increase by 0.85°C and sea level to increase by 19 cm relative to preindustrial times. Global climate change will lead to further alterations in mean temperature and...
Two specific goals were addressed for this dissertation. First to investigate and identify the mechanistic profile of ketoconazole (KT)-induced hepatotoxicity by utilizing in vivo and in vitro approaches determining the mechanism of action for the hepatotoxicity incurred. To date, there has not been a mechanistic determination of the hepatotoxicity associated...
The goal of this dissertation is to investigate the interaction between cimetidine and dietary flavonoids using the Caco-2 cell transport model. It has been shown that flavonoids can change the bioavailability of pharmaceuticals, either by inhibiting metabolizing enzymes or inhibiting the drug efflux transporters. However, the effect of dietary flavonoids...