Index Catalog // ScholarsArchive@OSU

Fibrinogen adsorption at heparinized silica interfaces : history dependence and protein concentration effects

Creator:: Joshi, Omkar
Abstract:: Adipic dihydrazide-modified heparin was prepared and subsequently immobilized on surface-activated silica wafers. X-ray photoelectron spectroscopy (XPS) was used to quantify the elemental composition of the silica surface at each stage of activation and results showed that successful immobilization had taken place. Contact angle measurements were made to verify the high...
Resource Type:: Masters Thesis
Full Text:: . Mike Schimerlik and Dr. Mike Penner for kindly serving on my committee. I must mention Dr Woo-Kul

Fibrinogen adsorption at heparinized silica interfaces : history dependence and adsorption time effects

Creator:: Lee, Hyo Jin
Abstract:: Heparin was modified with adipic diliydrazide and covalently linked to surface-activated silica. Contact angle measurements were made to determine changes in surface at various stages of the derivatization. Xray photoelectron spectroscopy was used to analyze the elemental composition of the surface at each step of immobilizing heparin as well and...
Resource Type:: Masters Thesis
Full Text:: Bird, for guiding me and taking the time to answer all my questions. I thank Dr. Mike Schimerlik and

Steps toward structure-assisted drug design

Creator:: Watts, K. Shawn
Abstract:: The three dimensional structure of both a ligand and its cognate receptor are required for the success of structure-assisted drug design. This thesis reports the crystal structure of hectochlorin, a small, bioactive molecule, and the steps toward determining the crystal structure of an RNA molecule that is an attractive target...
Resource Type:: Masters Thesis
Full Text:: members, Phil Proteau, Mike Schimerlik, and Mike Penner, for their help and guidance in writing this

Sequence dependent conformational variations in DNA holliday junctions

Creator:: Hays, Franklin A.
Abstract:: Four-stranded DNA junctions (also known as Holliday junctions) are structural intermediates involved in a growing number of biological processes including DNA repair, genetic recombination, and viral integration. Although previous studies have focused on understanding the conformational variability and sequence-dependent formation of Holliday junctions in solution there have been relatively few...
Resource Type:: Dissertation
Full Text:: doctoral committee for their support: Drs. Joe Beckman, Mike Schimerlik and Mary Slabaugh. I would like

Mass spectrometric analysis of bovine neurofilament proteins NF-L, NF-M, and NF-H : peptide mapping, phosphorylation and alkylation site identification

Creator:: Mixon, April E.
Abstract:: Neurofilament proteins are intermediate filaments found in the neuronal cytoskeleton. Phosphorylation of these proteins is considered important for the assembly and stability of the filaments. Accurate molecular weights have been difficult to measure, largely because the high degree of phosphorylation results in M[subscript r]'S that are significantly greater than dictated...
Resource Type:: Masters Thesis
Full Text:: and advice. I would also like to thank my committee members, Doug Barofsky, Mike Schimerlik, and Fred

Regulation of phosphofructokinase by reversible inactivation

Creator:: Zhao, Zhizhuang
Abstract:: The interaction of skeletal muscle phosphofructokinase with a variety of acidic proteins including calmodulin and troponin C and with nucleic acids (RNA and DNA) is manifest in a reversible, time-dependent loss of catalytic activity. The inactivation is affected by a number of factors. Substrates (fructose-6-phosphate and ATP), positive effectors (fructose-2,6-bisphosphate,...
Resource Type:: Dissertation
Full Text:: my graduate committee members, Dr. Mike Schimerlik, Dr. Wilbert Gamble, Dr. Henry Schaup, and Dr

Synthetic studies n bioactive natural products. Part I, An approach towards the nootrophic agent huperzine A. Part II, Synthesis of the tricarbonyl subunit of rapamycin

Creator:: Jeffrey, Scott C.
Resource Type:: Dissertation
Full Text:: Thanks to Professor James D. White White Group Post-Doctorates Steve Perri, Fraser Fleming, Mike

Alternatives to the DNA precursor-synthesizing enzyme complex hypothesis

Creator:: Weitz, Stephen L.
Abstract:: Investigators have been studying an aggregate containing enzymes of deoxyribonucleoside triphosphate biosynthesis in T4-phage infected bacteria. They suggest that it behaves as an organized complex, efficiently channeling DNA precursors to the replication apparatus. Previous work has suggested that about 10 enzyme activities remain associated through several fractionation steps. This multi-enzyme...
Resource Type:: Dissertation
Full Text:: part in helpful discussions and committee meetings. They include Dr. Ken Van Holde, Dr. Mike

Hydrogenase in Azotobacter vinelandii : the role of the heme ligands in HoxZ

Creator:: Meek, Laura
Resource Type:: Dissertation
Full Text:: , Mike Schimerlik, and Bob Becker for their help and suggestions for my research. I would also like to

ScholarsArchive@OSU

Fibrinogen adsorption at heparinized silica interfaces : history dependence and protein concentration effects

Fibrinogen adsorption at heparinized silica interfaces : history dependence and adsorption time effects

Steps toward structure-assisted drug design

Sequence dependent conformational variations in DNA holliday junctions

Mass spectrometric analysis of bovine neurofilament proteins NF-L, NF-M, and NF-H : peptide mapping, phosphorylation and alkylation site identification

Regulation of phosphofructokinase by reversible inactivation

Synthetic studies n bioactive natural products. Part I, An approach towards the nootrophic agent huperzine A. Part II, Synthesis of the tricarbonyl subunit of rapamycin

Alternatives to the DNA precursor-synthesizing enzyme complex hypothesis

Hydrogenase in Azotobacter vinelandii : the role of the heme ligands in HoxZ

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